Title:
SYSTEM, SOFTWARE AND METHODS FOR BIOMARKER IDENTIFICATION
Document Type and Number:
WIPO Patent Application WO2005017646
Kind Code:
A3
Abstract:
The invention provides a method, system and software to screen for, identify and validate biomarkers that are predictive of a biological state, such as a cell state and/or patient status.
Inventors:
ZHANG ZHEN (US)
CHAN DANIEL WANYUI (US)
CHAN DANIEL WANYUI (US)
Application Number:
PCT/US2003/024661
Publication Date:
May 19, 2005
Filing Date:
August 05, 2003
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
ZHANG ZHEN (US)
CHAN DANIEL WANYUI (US)
ZHANG ZHEN (US)
CHAN DANIEL WANYUI (US)
International Classes:
G01N33/48; G01N33/50; G06F15/18; G06F19/00; G16B20/00; G16B25/10; G16B40/20; G16B40/30; G06F; (IPC1-7): G01N33/48
Foreign References:
| US6789069B1 | 2004-09-07 |
Other References:
SU A.I. ET AL.: "Molecular classification of human carcinomas by use of gene expression", CANCER RESEARCH, vol. 61, 15 October 2001 (2001-10-15), pages 7388 - 7393, XP002295170
MATEOS A. ET AL.: "Systemic learning of gene functional classes form DNA array expression data by using multilayer perceptrons", GENOME RESEARCH, vol. 12, November 2002 (2002-11-01), pages 1703 - 1715, XP002985245
BROWN M.P. ET AL.: "Knowledge-based analysis of microarray gene expression data by using support vector machines", PNAS, vol. 97, no. 1, 4 January 2000 (2000-01-04), pages 262 - 267, XP002909076
GUNTHER E.C. ET AL.: "Prediciton of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro", PNAS, vol. 100, no. 16, 5 August 2003 (2003-08-05), pages 9608 - 9613, XP002985246
GOLUB T.R. ET AL.: "Molecular classification of cancer: class iscovery and class prediction by gene expression monitoring", SCIENCE, vol. 286, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658
MATEOS A. ET AL.: "Systemic learning of gene functional classes form DNA array expression data by using multilayer perceptrons", GENOME RESEARCH, vol. 12, November 2002 (2002-11-01), pages 1703 - 1715, XP002985245
BROWN M.P. ET AL.: "Knowledge-based analysis of microarray gene expression data by using support vector machines", PNAS, vol. 97, no. 1, 4 January 2000 (2000-01-04), pages 262 - 267, XP002909076
GUNTHER E.C. ET AL.: "Prediciton of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro", PNAS, vol. 100, no. 16, 5 August 2003 (2003-08-05), pages 9608 - 9613, XP002985246
GOLUB T.R. ET AL.: "Molecular classification of cancer: class iscovery and class prediction by gene expression monitoring", SCIENCE, vol. 286, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658
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