Title:
T CELL FOR EFFICIENTLY AND STABLY EXPRESSING ANTIBODY AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/219933
Kind Code:
A1
Abstract:
Provided is a transgenic T cell. A genome of the T cell stably integrates an expression cassette comprising an encoding sequence of an antibody in a human FC fragment, and two ends of the expression cassette comprise an inverted terminal repeat sequence of transposons. Also provided are a pharmaceutical combination comprising the transgenic T cell and an application thereof.
Inventors:
QIAN QIJUN (CN)
JIN HUAJUN (CN)
XU JIEYING (CN)
LI LINFANG (CN)
YE ZHENLONG (CN)
WANG CHAO (CN)
JIANG DUQING (CN)
WU HONGPING (CN)
JIN HUAJUN (CN)
XU JIEYING (CN)
LI LINFANG (CN)
YE ZHENLONG (CN)
WANG CHAO (CN)
JIANG DUQING (CN)
WU HONGPING (CN)
Application Number:
PCT/CN2017/088952
Publication Date:
December 28, 2017
Filing Date:
June 19, 2017
Export Citation:
Assignee:
SHANGHAI CELL THERAPY RES INST (CN)
SHANGHAI ENGINEERING RES CENTER FOR CELL THERAPY GROUP CO LTD (CN)
SHANGHAI ENGINEERING RES CENTER FOR CELL THERAPY GROUP CO LTD (CN)
International Classes:
C12N5/10; A61K35/17; A61K48/00; A61P35/00; C12N15/13; C12N15/85
Foreign References:
| CN105154473A | 2015-12-16 | |||
| CN104745581A | 2015-07-01 | |||
| CN105330750A | 2016-02-17 |
Other References:
SAHA, S. ET AL.: "piggyBac Transposon System Modification of Primary Human T Cells", JOURNAL OF VISUALIZED EXPERIMENTS, vol. 69, 11 May 2012 (2012-05-11), pages 1 - 5, XP055181355, ISSN: 1940-087X
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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