Title:
T-TYPE CALCIUM CHANNEL BLOCKER
Document Type and Number:
WIPO Patent Application WO/2022/260016
Kind Code:
A1
Abstract:
The present invention provides a compound that has a T-type calcium channel blocking effect and that is represented by formula (I) [in the formula, R1, R2, R3, R4, k, l, m, and n are as defined in the description] or a pharmacologically acceptable salt thereof, and a drug that is useful in the treatment of diseases caused by activation of T-type calcium channels.
Inventors:
KAWABATA ATSUFUMI (JP)
SEKIGUCHI FUMIKO (JP)
TOYOOKA NAOKI (JP)
OKADA TAKUYA (JP)
NISHIKAWA HIROYUKI (JP)
SEKIGUCHI FUMIKO (JP)
TOYOOKA NAOKI (JP)
OKADA TAKUYA (JP)
NISHIKAWA HIROYUKI (JP)
Application Number:
PCT/JP2022/022847
Publication Date:
December 15, 2022
Filing Date:
June 06, 2022
Export Citation:
Assignee:
UNIV KINKI (JP)
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
FUSO PHARMACEUTICAL IND (JP)
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
FUSO PHARMACEUTICAL IND (JP)
International Classes:
C07D235/26; A61K31/4184; A61K31/454; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/04; A61P25/04; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P35/00; A61P43/00; C07D401/04
Domestic Patent References:
| WO2015050212A1 | 2015-04-09 |
Foreign References:
| JP2020517701A | 2020-06-18 | |||
| JPS5524104A | 1980-02-21 | |||
| JPS5113780A | 1976-02-03 | |||
| JP2009525269A | 2009-07-09 | |||
| JP2011513326A | 2011-04-28 | |||
| JP2008510731A | 2008-04-10 |
Other References:
CLARK R L, PESSOLANO A A: "Synthesis of Some substituted Benzimidazolones", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 80, 1 January 1958 (1958-01-01), pages 1657 - 1662, XP002424964, ISSN: 0002-7863, DOI: 10.1021/ja01540a037
TODOROVIC, NEURON, vol. 31, no. 1, 2001, pages 75 - 85
HUANG, J PHARMACOL EXP THER., vol. 309, no. 1, pages 193 - 199
T. W. GREENE, P. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
J. MED. CHEM., vol. 61, 2018, pages 8895 - 8907
SHIMADA SG, LAMOTTE RH: "Behavioral differentiation between itch and pain in mouse", PAIN, vol. 139, no. 3, 2008, pages 681 - 687, XP025520147, DOI: 10.1016/j.pain.2008.08.002
TODOROVIC, NEURON, vol. 31, no. 1, 2001, pages 75 - 85
HUANG, J PHARMACOL EXP THER., vol. 309, no. 1, pages 193 - 199
T. W. GREENE, P. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
J. MED. CHEM., vol. 61, 2018, pages 8895 - 8907
SHIMADA SG, LAMOTTE RH: "Behavioral differentiation between itch and pain in mouse", PAIN, vol. 139, no. 3, 2008, pages 681 - 687, XP025520147, DOI: 10.1016/j.pain.2008.08.002
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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