TARGETED FIBERLESS RADIATIVE EFFECTORS

WIPO Patent Application WO2001008660

A3

The present invention is related to cell or pathogen destruction via fiberless radiative effectors that encapsulate a free radical generator. Fiberless radiative effectors include a polymer matrix, a photodynamic or radiodynamic dye which produces free radicals upon stimulation, cloaking material, and at least one molecular recognition element for targeting to a biological target. Other fiberless radiative effectors may be used for imaging biological targets, and include a compound which is detectable by an imaging system, such as luciferase or iron.

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PHILBERT MARTIN A (GB)
TJALKENS RONALD (US)
AYLOTT JONATHAN W (US)
CLARK HEATHER A (US)
MONSON ERIC E (US)
KOPELMAN RAOUL (US)

PCT/US2000/020292

November 22, 2001

July 26, 2000

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UNIV MICHIGAN (US)
PHILBERT MARTIN A (GB)
TJALKENS RONALD (US)
AYLOTT JONATHAN W (US)
CLARK HEATHER A (US)
MONSON ERIC E (US)
KOPELMAN RAOUL (US)

A61K41/00; A61K49/00; A61K51/12; (IPC1-7): A61K51/12; A61K41/00; A61K49/00

WO1999002651A1	1999-01-21
WO1997046262A2	1997-12-11
WO1996023524A1	1996-08-08
WO2000043045A1	2000-07-27

US5599923A

1997-02-04

CLARK H A ET AL: "OPTOCHEMICAL NANOSENSORS AND SUBCELLAR APPLICATIONS IN LIVING CELLS", MIKROCHIMICA ACTA,SPRINGER VERLAG, VIENNA,AT, vol. 131, no. 1/02, 1999, pages 121 - 128, XP000992957, ISSN: 0026-3672

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