TARGETING CONJUGATES WITH THERAPEUTIC AGENTS AND OLIGONUCLEOTIDES AND USES THEREOF

Title:

TARGETING CONJUGATES WITH THERAPEUTIC AGENTS AND OLIGONUCLEOTIDES AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/178754

Kind Code:

A1

Abstract:

Provided are targeting conjugates comprising a targeting moiety, a therapeutic agent, and an oligonucleotide, wherein the oligonucleotide is attached to the targeting moiety via a targeting moiety binding fragment (TBF), wherein the therapeutic agent and/or the oligonucleotide can be released from the targeting conjugate via cleavage. Also provided are pharmaceutical compositions and methods of treatment using the targeting conjugates.

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Inventors:

XIANG JUN (CN)
GAO WENLONG (CN)

Application Number:

PCT/CN2021/077868

Publication Date:

September 01, 2022

Filing Date:

February 25, 2021

Export Citation:

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Assignee:

SHANGHAI ALLYGEN BIOLOGICS CO LTD (CN)

International Classes:

A61K47/42; A61K31/713; C07K19/00

Domestic Patent References:

WO1994013325A2	1994-06-23
WO2012030745A1	2012-03-08
WO2016160822A1	2016-10-06
WO2018117613A1	2018-06-28
WO2016077505A2	2016-05-19
WO2012178173A1	2012-12-27

Foreign References:

US20180141976A1

2018-05-24

Other References:

ANDRÉ RAPOSO MOREIRA DIAS; ARIANNA PINA; AMELIA DEAN; HANS-GEORG LERCHEN; MICHELE CARUSO; FABIO GASPARRI; IVAN FRAIETTA; SONIA TRO: "Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 25, no. 7, 1 February 2019 (2019-02-01), DE, pages 1696 - 1700, XP055657811, ISSN: 0947-6539, DOI: 10.1002/chem.201805447
BARGH JONATHAN D; ISIDRO-LLOBET ALBERT; PARKER JEREMY S; SPRING DAVID R: "Cleavable linkers in antibody-drug conjugates", CHEMICAL SOCIETY REVIEWS, vol. 48, no. 16, 21 August 2019 (2019-08-21), UK , pages 4361 - 4374, XP009517547, ISSN: 0306-0012, DOI: 10.1039/c8cs00676h

Attorney, Agent or Firm:

BEIJING CAI HE LAW FIRM (CN)

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