TARTARIC ACID DERIVATIVE AND HIGH-MOLECULAR WEIGHT CROSSLINKED MATTER SYNTHESIZED BY USING THE DERIVATIVE

Title:

TARTARIC ACID DERIVATIVE AND HIGH-MOLECULAR WEIGHT CROSSLINKED MATTER SYNTHESIZED BY USING THE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2006/016600

Kind Code:

A1

Abstract:

Because of being not natural but artificially synthesized substances, adhesives for biological use and crosslinking agents and condensing agents having been employed in treating medical devices such as cardiac valves exhibit toxicity without being metabolized in vivo. To dissolve them, organic solvents are needed. Thus, it has been required to develop a water-soluble crosslinking agent having a high biocompatibility. A water-soluble tartaric acid derivative obtained by modifying a carboxyl group of tartaric acid and its derivative having a hydroxyl group in molecule with an electron-withdrawing group such as succinimidyl, sulfosuccinimidyl, maleimidyl, phthalimidyl, imidazolyl, nitrophenyl or tresyl or a combination of two or more thereof, and a high-molecular weight crosslinked matter obtained by using this tartaric acid derivative.

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Inventors:

TAGUCHI TETSUSHI (JP)
KOBAYASHI HISATOSHI (JP)
TANAKA JUNZO (JP)
SAITO HIROFUMI (JP)
AOKI HIROKATSU (JP)

Application Number:

PCT/JP2005/014636

Publication Date:

February 16, 2006

Filing Date:

August 10, 2005

Export Citation:

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Assignee:

NAT INST FOR MATERIALS SCIENCE (JP)
FURUUCHI CHEMICAL CORP (JP)
TAGUCHI TETSUSHI (JP)
KOBAYASHI HISATOSHI (JP)
TANAKA JUNZO (JP)
SAITO HIROFUMI (JP)
AOKI HIROKATSU (JP)

International Classes:

C07D207/408; A61L15/64; A61L24/00; C07D209/48; C08J3/24; C08L101/00

Foreign References:

US4101380A	1978-07-18
JP2004099562A	2004-04-02
JPH02180903A	1990-07-13
JP2004261222A	2004-09-24
JP2005168949A	2005-06-30

Attorney, Agent or Firm:

Nishi, Yoshiyuki (Suite 704, 17-1, Sugita 1-chome,, Isogo-ku, Yokohama-sh, Kanagawa, JP)

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