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Title:
TC AND RE CARBONYL COMPLEXES FOR PERTECHNETATE AND PERRHENATE
Document Type and Number:
WIPO Patent Application WO2001089586
Kind Code:
A3
Abstract:
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as therapeutic agents and as imaging agents for diagnostic purposes. In accordance with the present invention, a method of preparing a compound of formula fac- [M(CO)3(O H2)3]<+> (I) wherein M is Mn, <99m>Tc, <186>Re or <188>Re, involves reacting a metal in permetallate form with carbon monoxide and stannous ion. The compound of formula (I) can be reacted with a ligand Lx, to form a compound of the formula fac -[M(CO)3Lx] (II) wherein M is as defined above, Lx is a monodentate or multidentate ligand or a mixture of these ligands, and n is a charge of the ligand Lx increased with one + charge. The invention also is directed to novel compounds, and kits for carrying out the disclosed methods.

Inventors:
PIPES DAVID W (US)
DYSZLEWSKI MARY E (US)
WEBB ELIZABETH G (US)
Application Number:
US0115670W
Publication Date:
August 22, 2002
Filing Date:
May 08, 2001
Export Citation:
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Assignee:
MALLINCKRODT INC.
PIPES, DAVID, W.
DYSZLEWSKI, MARY, E.
WEBB, ELIZABETH, G.
International Classes:
G21H5/02; A61K49/08; A61K51/00; A61K51/04; A61P43/00; C01G45/04; C01G47/00; C01G99/00; C07F5/00; C07F13/00; (IPC1-7): A61K51/04; C07F13/00
Domestic Patent References:
WO2001025243A12001-04-12
WO2001000637A12001-01-04
Foreign References:
EP0879606A11998-11-25
Other References:
EGLI A ET AL: "HYDROLYSIS OF THE ORGANOMETALLIC AQUA ION FAC-TRIAQUATRICARBONYLRHENI UM(I). MECHANISM. PKA, AND FORMATION CONSTANTS OF THE POLYNUCLEAR HYDROLYSIS PRODUCTS" ORGANOMETALLICS, WASHINGTON, DC, US, vol. 9, no. 16, 1997, pages 1833-1840, XP001074762 ISSN: 0276-7333
DYSZLESWKI M E ET AL: "KIT FORMULATION AND PRELIMINARY TOXICITY OF 99MTC(CO)3+ INTERMEDIATE: A NOVEL TECHNETIUM RADIOPHARMACEUTICAL PLATFORM" JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, SUSSEX, GB, vol. SUPPL. 1, no. 44, 2001, pages S483-S485, XP008003317 ISSN: 0362-4803
ALBERTO R ET AL: "BASIC AQUEOUS CHEMISTRY OF M(OH2)3(CO)3+(M=REM TC) DIRECTED TOWARDS RADIOPHARMACEUTICAL APPLICATION" COORDINATION CHEMISTRY REVIEWS, ELSEVIER SCIENCE, AMSTERDAM, NL, no. 190-192, 1999, pages 901-919, XP001074720 ISSN: 0010-8545
SEIFERT S ET AL: "REACTIVITY OF TECHNETIUM(I) THIOETHER CARBONYL COMPLEXES TOWARDS HISTIDINE-AN EXAFS STUDY IN SOLUTION" INORGANICA CHIMICA ACTA, LAUSANNE, CH, no. 322, 2001, pages 79-86, XP001074703 ISSN: 0020-1693
ALBERTO R ET AL: "FIRST APPLICATION OF FAC-99MTC(0H2)3(CO)3+ IN BIOORGANOMETALLIC CHEMISTRY: DESIGN, STRUCTURE, AND IN VITRO AFFINITY OF A 5-HT1A RECEPTOR LIGAD LABELED WITH 99MTC" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 25, no. 121, 1999, pages 6076-6077, XP001074704 ISSN: 0002-7863
MEDER H-J ET AL: "METALLKOMPLEXE MIT BIOLOGISCH WICHTIGEN LIGANDEN, XLII U1 CARBONYLMETALLKOMPLEXE MIT ANIONEN VON MEHRFUNKTIONELLEN ALPHA- AMINOSAEUREN. METAL COMPLEXES WITH BIOLOGICALLY IMPORTANT LIGANDS, XLII U1 CARBONYL METAL COMPLEXES WITH ANIONS OF POLYFUNCTIONAL ALPHA-AMINO ACIDS" ZEITSCHRIFT FUR NATURFORSCHUNG, TEIL B: ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE, VERLAG DER ZEITSCHRIFT FUR NATURFORSCHUNG. TUBINGEN, DE, 1986, pages 1247-1254, XP002043521 ISSN: 0932-0776
BAMFORD C H ET AL: "EVIDENCE FOR THE FORMATION OF THE TRIAQUATRICARBONYLMANGANESE(L) CATION AND RELATED DERIVATIVES FROM PENTACARBONYLCHLOROMANGANESE" JOURNAL OF THE CHEMICAL SOCIETY, DALTON TRANSACTIONS, CHEMICAL SOCIETY. LETCHWORTH, GB, no. 1, 1978, pages 4-8, XP002043519 ISSN: 1472-7773
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