Title:
TCR FOR IDENTIFYING AFP ANTIGEN AND CODING SEQUENCE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/262835
Kind Code:
A1
Abstract:
The present application provides a T cell receptor (TCR) capable of specifically binding to a short peptide TSSELMAITR (SEQ ID NO: 9) derived from an AFP antigen, wherein the antigenic short peptide TSSELMAITR (SEQ ID NO: 9) may form a complex with HLA A1101 and be presented to the cell surface together with HLA A1101. The present application also provides a nucleic acid molecule encoding the TCR and a vector containing the nucleic acid molecule. In addition, the present application also provides a cell for transducing the TCR of the present application.
Inventors:
YANG DONGXUE (CN)
ZHONG SHI (CN)
LIAO YOUPING (CN)
ZHENG WENJING (CN)
WEN QIAOSHENG (CN)
MA RUIJUAN (CN)
SUN HANLI (CN)
ZHONG SHI (CN)
LIAO YOUPING (CN)
ZHENG WENJING (CN)
WEN QIAOSHENG (CN)
MA RUIJUAN (CN)
SUN HANLI (CN)
Application Number:
PCT/CN2022/099352
Publication Date:
December 22, 2022
Filing Date:
June 17, 2022
Export Citation:
Assignee:
XLIFESC LTD (CN)
International Classes:
C07K14/725; A61K38/17; A61P35/00; A61P37/02; C12N5/10; C12N15/12; C12N15/867
Domestic Patent References:
| WO2021022447A1 | 2021-02-11 |
Foreign References:
| CN110343166A | 2019-10-18 | |||
| CN111171137A | 2020-05-19 | |||
| CN111171156A | 2020-05-19 |
Other References:
WANG XIAOLEI: "Research Progress on the Association of T cell Cloning with Alpha-fetoprotein", YI XUE LI LUN YU SHI JIAN : SHUANG YUE KAN = THE JOURNAL OF MEDICAL THEORY AND PRACTICE, LANGFANG, HEBEI, CN, vol. 25, no. 2, 25 January 2012 (2012-01-25), CN , XP093015308, ISSN: 1001-7585, DOI: 10.19381/j.issn.1001-7585.2012.02.014
ROCHIGNEUX PHILIPPE, CHANEZ BRICE, DE RAUGLAUDRE BERNADETTE, MITRY EMMANUEL, CHABANNON CHRISTIAN, GILABERT MARINE: "Adoptive Cell Therapy in Hepatocellular Carcinoma: Biological Rationale and First Results in Early Phase Clinical Trials", CANCERS, vol. 13, no. 2, 1 January 2021 (2021-01-01), pages 271, XP093015310, DOI: 10.3390/cancers13020271
ROCHIGNEUX PHILIPPE, CHANEZ BRICE, DE RAUGLAUDRE BERNADETTE, MITRY EMMANUEL, CHABANNON CHRISTIAN, GILABERT MARINE: "Adoptive Cell Therapy in Hepatocellular Carcinoma: Biological Rationale and First Results in Early Phase Clinical Trials", CANCERS, vol. 13, no. 2, 1 January 2021 (2021-01-01), pages 271, XP093015310, DOI: 10.3390/cancers13020271
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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