Title:
TECHNETIUM-AND RHENIUM-BIS(HETEROARYL)COMPLEXES AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/065899
Kind Code:
A3
Abstract:
Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecule, and a tridentate chelator that may complex the radionuclide. The bioactive molecule may be a peptide or somatostatin.
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Inventors:
BABICH JOHN W (US)
ZIMMERMAN CRAIG (US)
JOYAL JOHN (US)
MARESCA KEVIN P (US)
MARQUIS JOHN (US)
LU GENLIANG (US)
WANG JIAN-CHENG (US)
HILLIER SHAWN (US)
ZIMMERMAN CRAIG (US)
JOYAL JOHN (US)
MARESCA KEVIN P (US)
MARQUIS JOHN (US)
LU GENLIANG (US)
WANG JIAN-CHENG (US)
HILLIER SHAWN (US)
Application Number:
PCT/US2009/066832
Publication Date:
December 02, 2010
Filing Date:
December 04, 2009
Export Citation:
Assignee:
MOLECULAR INSIGHT PHARM INC (US)
BABICH JOHN W (US)
ZIMMERMAN CRAIG (US)
JOYAL JOHN (US)
MARESCA KEVIN P (US)
MARQUIS JOHN (US)
LU GENLIANG (US)
WANG JIAN-CHENG (US)
HILLIER SHAWN (US)
BABICH JOHN W (US)
ZIMMERMAN CRAIG (US)
JOYAL JOHN (US)
MARESCA KEVIN P (US)
MARQUIS JOHN (US)
LU GENLIANG (US)
WANG JIAN-CHENG (US)
HILLIER SHAWN (US)
International Classes:
C07D213/38; A61K51/04; A61K51/08; C07F13/00
Domestic Patent References:
| WO2005079865A1 | 2005-09-01 | |||
| WO2003077727A2 | 2003-09-25 | |||
| WO2005056520A1 | 2005-06-23 | |||
| WO2009076434A1 | 2009-06-18 | |||
| WO2007090461A1 | 2007-08-16 | |||
| WO2007148738A1 | 2007-12-27 |
Foreign References:
| US20040209921A1 | 2004-10-21 | |||
| US20090175794A1 | 2009-07-09 | |||
| US20080227962A1 | 2008-09-18 | |||
| US20050038258A1 | 2005-02-17 | |||
| EP1961744A1 | 2008-08-27 | |||
| EP1550657A1 | 2005-07-06 | |||
| EP1389460A1 | 2004-02-18 |
Other References:
BANERJEE S R ET AL: "Bifunctional Single Amino Acid Chelates for Labeling of Biomolecules with the {Tc(CO)3}+ and {Re(CO)3}+ Cores. Crystal and Molecular Structures of [ReBr(CO)3(H2NCH2C5H4N)], [Re(CO)3{(C5H4NCH2)2NH}]Br, [Re(CO)3{(C5H4NCH2)2NCH2CO2H}]Br, [Re(CO)3{X(Y)NCH2CO2CH2CH3}]Br (X = Y = 2-pyridylmethyl; X = 2-py", INORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, US LNKD- DOI:10.1021/IC020476E, vol. 41, no. 24, 7 November 2002 (2002-11-07), pages 6417 - 6425, XP002380958, ISSN: 0020-1669
BANERJEE S R ET AL: "RE(III)C13 Core complexes with bifunctional single amino acid chelates", INORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, US LNKD- DOI:10.1021/IC020391D, vol. 41, no. 22, 1 January 2002 (2002-01-01), pages 5795 - 5802, XP008112145, ISSN: 0020-1669, [retrieved on 20020928]
KOJIMA TAKAHIKO ET AL: "Synthesis and characterization of mononuclear ruthenium(III) pyridylamine complexes and mechanistic insights into their catalytic alkane functionalization with m-chloroperbenzoic acid.", 2007, CHEMISTRY (WEINHEIM AN DER BERGSTRASSE, GERMANY) 2007 LNKD- PUBMED:17625799, VOL. 13, NR. 29, PAGE(S) 8212 - 8222, ISSN: 0947-6539, XP002577056
BONOMI RENATO ET AL: "Phosphate diester and DNA hydrolysis by a multivalent, nanoparticle-based catalyst.", 26 November 2008, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 26 NOV 2008 LNKD- PUBMED:18975902, VOL. 130, NR. 47, PAGE(S) 15744 - 15745, ISSN: 1520-5126, XP002577057
THALLAJ NASSER K ET AL: "A ferrous center as reaction site for hydration of a nitrile group into a carboxamide in mild conditions.", 27 February 2008, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 27 FEB 2008 LNKD- PUBMED:18232692, VOL. 130, NR. 8, PAGE(S) 2414 - 2415, ISSN: 1520-5126, XP002577058
HENSON MARK J ET AL: "Resonance raman investigation of equatorial ligand donor effects on the Cu(2)O(2)(2+) core in end-on and side-on mu-peroxo-dicopper(II) and bis-mu-oxo-dicopper(III) complexes.", 30 April 2003, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 30 APR 2003 LNKD- PUBMED:12708870, VOL. 125, NR. 17, PAGE(S) 5186 - 5192, ISSN: 0002-7863, XP002577059
FENG GUOQIANG ET AL: "Comparing a mononuclear Zn(II) complex with hydrogen bond donors with a dinuclear Zn(II) complex for catalysing phosphate ester cleavage.", 7 May 2006, CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND) 7 MAY 2006 LNKD- PUBMED:16622503, NR. 17, PAGE(S) 1845 - 1847, ISSN: 1359-7345, XP002577060
NONAT ALINE ET AL: "Structure, stability, dynamics, high-field relaxivity and ternary-complex formation of a new tris(aquo) gadolinium complex.", 2007, CHEMISTRY (WEINHEIM AN DER BERGSTRASSE, GERMANY) 2007 LNKD- PUBMED:17659512, VOL. 13, NR. 30, PAGE(S) 8489 - 8506, ISSN: 0947-6539, XP002577061
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1958, PROFFT, XP002577062, Database accession no. Citation No 990210
ALBERTO ET AL: "A Novel Organometallic Aqua Complex of Technetium for the Labeling of Biomolecules: Synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4]- in Aqueous Solution and Its Reaction with a Bifunctional Ligand", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, NEW YORK, USA LNKD- DOI:10.1021/JA980745T, vol. 120, no. 31, 1 January 1998 (1998-01-01), pages 7987 - 7988, XP002149527, ISSN: 0002-7863
BANERJEE S R ET AL: "RE(III)C13 Core complexes with bifunctional single amino acid chelates", INORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, US LNKD- DOI:10.1021/IC020391D, vol. 41, no. 22, 1 January 2002 (2002-01-01), pages 5795 - 5802, XP008112145, ISSN: 0020-1669, [retrieved on 20020928]
KOJIMA TAKAHIKO ET AL: "Synthesis and characterization of mononuclear ruthenium(III) pyridylamine complexes and mechanistic insights into their catalytic alkane functionalization with m-chloroperbenzoic acid.", 2007, CHEMISTRY (WEINHEIM AN DER BERGSTRASSE, GERMANY) 2007 LNKD- PUBMED:17625799, VOL. 13, NR. 29, PAGE(S) 8212 - 8222, ISSN: 0947-6539, XP002577056
BONOMI RENATO ET AL: "Phosphate diester and DNA hydrolysis by a multivalent, nanoparticle-based catalyst.", 26 November 2008, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 26 NOV 2008 LNKD- PUBMED:18975902, VOL. 130, NR. 47, PAGE(S) 15744 - 15745, ISSN: 1520-5126, XP002577057
THALLAJ NASSER K ET AL: "A ferrous center as reaction site for hydration of a nitrile group into a carboxamide in mild conditions.", 27 February 2008, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 27 FEB 2008 LNKD- PUBMED:18232692, VOL. 130, NR. 8, PAGE(S) 2414 - 2415, ISSN: 1520-5126, XP002577058
HENSON MARK J ET AL: "Resonance raman investigation of equatorial ligand donor effects on the Cu(2)O(2)(2+) core in end-on and side-on mu-peroxo-dicopper(II) and bis-mu-oxo-dicopper(III) complexes.", 30 April 2003, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 30 APR 2003 LNKD- PUBMED:12708870, VOL. 125, NR. 17, PAGE(S) 5186 - 5192, ISSN: 0002-7863, XP002577059
FENG GUOQIANG ET AL: "Comparing a mononuclear Zn(II) complex with hydrogen bond donors with a dinuclear Zn(II) complex for catalysing phosphate ester cleavage.", 7 May 2006, CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND) 7 MAY 2006 LNKD- PUBMED:16622503, NR. 17, PAGE(S) 1845 - 1847, ISSN: 1359-7345, XP002577060
NONAT ALINE ET AL: "Structure, stability, dynamics, high-field relaxivity and ternary-complex formation of a new tris(aquo) gadolinium complex.", 2007, CHEMISTRY (WEINHEIM AN DER BERGSTRASSE, GERMANY) 2007 LNKD- PUBMED:17659512, VOL. 13, NR. 30, PAGE(S) 8489 - 8506, ISSN: 0947-6539, XP002577061
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1958, PROFFT, XP002577062, Database accession no. Citation No 990210
ALBERTO ET AL: "A Novel Organometallic Aqua Complex of Technetium for the Labeling of Biomolecules: Synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4]- in Aqueous Solution and Its Reaction with a Bifunctional Ligand", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, NEW YORK, USA LNKD- DOI:10.1021/JA980745T, vol. 120, no. 31, 1 January 1998 (1998-01-01), pages 7987 - 7988, XP002149527, ISSN: 0002-7863
Attorney, Agent or Firm:
VILLACORTA, Gilberto, M. et al. (Washington Harbour3000 K St., NW,Sixth Floo, Washington DC, US)
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