Title:
TETRACYCLIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO1984002704
Kind Code:
A2
Abstract:
Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: X is CH2, O, S, or NR where R is C1-4 alkyl; R1 and R2 are independently selected from hydrogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, halogen or CF3; R3 is C1-7 alkyl, C2-5 alkynyl, C3-7 cycloalkyl, C4-7 cycloalkenyl or C1-6 alkyl substituted by C2-7 alkenyl, C2-7alkynyl, C3-7 cycloalkyl, hydroxy, thiol, C1-6 alkoxy, C1-6 alkylthio, carboxy, C1-6 alkoxycarbonyl, C2-7 alkanoyl, amino optionally substituted by one or two C1-4 alkyl or by C4-6 polymethylene optionally containing an oxygen or nitrogen atom, aminocarbonyl optionally N-substituted by one or two C1-6 alkyl groups, or benzoyl or phenyl either being optionally ring-substituted by one or two C1-4 alkyl, C1-4 alkoxy, halogen or trifluoromethyl; and one of R4, R5 and R6 is C1-6 alkyl and the other two are independently hydrogen or C1-6 alkyl, having anti-depressant and/or anxiolytic activity, a process for their preparation and their use.
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Inventors:
CONNELL ANTHONY CHRISTOPHER (GB)
Application Number:
PCT/GB1983/000353
Publication Date:
July 19, 1984
Filing Date:
December 29, 1983
Export Citation:
Assignee:
BEECHAM GROUP PLC (GB)
International Classes:
A61K31/55; C07C233/07; C07D223/00; C07D223/20; C07D235/00; C07D243/00; C07D243/38; C07D267/00; C07D267/20; C07D281/00; C07D281/14; C07D281/16; C07D487/00; C07D487/04; C07D498/00; C07D498/04; C07D513/00; C07D513/04
Foreign References:
| EP0035749A1 | 1981-09-16 | |||
| GB1404642A | 1975-09-03 | |||
| GB1421006A | 1976-01-14 | |||
| US3435042A | 1969-03-25 | |||
| EP0073506A1 | 1983-03-09 |
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