Title:
THERAPEUTIC AGENT, GENE THERAPY AGENT, AND METHOD FOR PREVENTING INVASION OF EOSINOPHIL
Document Type and Number:
WIPO Patent Application WO/2013/051435
Kind Code:
A1
Abstract:
[Problem] To provide: a therapeutic agent for eosinophilic sinusitis and eosinophilic otitis media; a gene therapy agent; and a method for preventing the invasion of an eosinophil.
[Solution] A therapeutic agent which can be used for the treatment of eosinophilic sinusitis and/or eosinophilic otitis media, which comprises siRNA capable of inhibiting the expression of a STAT-6 gene, siRNA capable of inhibiting the expression of a GATA-3 gene and/or siRNA capable of inhibiting the expression of an IL-5 gene as an active ingredient.
Inventors:
SUZUKI MOTOHIKO (JP)
Application Number:
PCT/JP2012/074623
Publication Date:
April 11, 2013
Filing Date:
September 26, 2012
Export Citation:
Assignee:
PUBLIC UNIV CORP NAGOYA CITY UNIV (JP)
International Classes:
A61K48/00; A61K31/713; A61K35/76; A61P11/02; A61P27/16; A61P29/00; C12N15/113
Domestic Patent References:
| WO2010107958A1 | 2010-09-23 | |||
| WO2010107957A2 | 2010-09-23 | |||
| WO2005011610A2 | 2005-02-10 | |||
| WO2004045543A2 | 2004-06-03 | |||
| WO2010104959A1 | 2010-09-16 |
Foreign References:
| JP2009536518A | 2009-10-15 | |||
| JP2007537157A | 2007-12-20 |
Other References:
YUICHI KURONO: "Tokushu Kosankyu Kanren no Byohen 1. Kosankyu Soron", OTOLARYNGOLOGY-HEAD AND NECK SURGERY, vol. 82, no. 10, 2010, pages 653 - 659
JUN'ICHIRO OHORI ET AL.: "Eosinophil Infiltration Mechanisms in Chronic Rhinosinusitis", PRACTICA OTO-RHINO- LARYNGOLOGICA, vol. 104, no. 7, July 2011 (2011-07-01), pages 465 - 473
TAKENO S ET AL.: "Pathological mechanisms and clinical features of eosinophilic chronic rhinosinusitis in the Japanese population.", ALLERGOL INT., vol. 59, no. 3, 2010, pages 247 - 56, XP055064560
PELIKAN Z.: "Role of nasal allergy in chronic secretory otitis media.", CURR ALLERGY ASTHMA REP., vol. 99, no. 2, 2009, pages 107 - 13, XP055064563
JUN'ICHIRO OHORI ET AL.: "Eosinophil Infiltration Mechanisms in Chronic Rhinosinusitis", PRACTICA OTO-RHINO- LARYNGOLOGICA, vol. 104, no. 7, July 2011 (2011-07-01), pages 465 - 473
TAKENO S ET AL.: "Pathological mechanisms and clinical features of eosinophilic chronic rhinosinusitis in the Japanese population.", ALLERGOL INT., vol. 59, no. 3, 2010, pages 247 - 56, XP055064560
PELIKAN Z.: "Role of nasal allergy in chronic secretory otitis media.", CURR ALLERGY ASTHMA REP., vol. 99, no. 2, 2009, pages 107 - 13, XP055064563
Attorney, Agent or Firm:
KITAGAWA Osamu et al. (JP)
Kitagawa 治 (JP)
Kitagawa 治 (JP)
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Claims: