Title:
THERAPEUTIC AGENT FOR HEART DISEASE, WHICH IS INTENDED TO BE USED IN CELL TRANSPLANTATION THERAPY
Document Type and Number:
WIPO Patent Application WO/2009/048166
Kind Code:
A1
Abstract:
The object is to establish a cell transplantation therapy using a multipotent
stem cell derived from a cardiac tissue, which can significantly improve the
adhesion of the multipotent stem cell and the efficiency of the regeneration
of a cardiac muscle cell, and which can treat a heart disease more effectively.
In a cell transplantation therapy for a heart disease, a combination of a multipotent
stem cell derived from a cardiac tissue and a hydrogel containing a basic fibroblast
growth factor (bFGF) is used, whereby the adhesion of the multipotent stem cell
can be increased and the efficiency of the regeneration of a cardiac muscle cell
can be improved significantly.
Inventors:
OH HIDEMASA (JP)
TAKEHARA NAOFUMI (JP)
MATSUBARA HIROAKI (JP)
TABATA YASUHIKO (JP)
TAKEHARA NAOFUMI (JP)
MATSUBARA HIROAKI (JP)
TABATA YASUHIKO (JP)
Application Number:
PCT/JP2008/068809
Publication Date:
April 16, 2009
Filing Date:
October 09, 2008
Export Citation:
Assignee:
UNIV KYOTO (JP)
OH HIDEMASA (JP)
TAKEHARA NAOFUMI (JP)
MATSUBARA HIROAKI (JP)
TABATA YASUHIKO (JP)
OH HIDEMASA (JP)
TAKEHARA NAOFUMI (JP)
MATSUBARA HIROAKI (JP)
TABATA YASUHIKO (JP)
International Classes:
A61L27/00; A61K9/70; A61K35/12; A61K35/34; A61K35/545; A61K38/22; A61K47/36; A61K47/42; A61L27/16; A61L27/22; A61L27/24; A61L27/38; A61L27/52; A61L27/54; A61L27/58; A61P9/00; A61P9/10
Domestic Patent References:
| WO2006093276A1 | 2006-09-08 | |||
| WO2006093276A1 | 2006-09-08 |
Foreign References:
| JP2002145797A | 2002-05-22 | |||
| JP2004167202A | 2004-06-17 | |||
| JP2002145797A | 2002-05-22 | |||
| JP2001316282A | 2001-11-13 | |||
| JPH05111382A | 1993-05-07 |
Other References:
MATSUBARA H.: "Hito Shinkin ? Kokkakukin Karano Shinkin Kansaibokabu no Juritsu to Makki Shinfuzen eno Kansaibo Ishoku Iryo Jitsugenka e Mukete no Kenkyu Kiban Keisei", RESEARCH OF NEW MEDICAL DEVICES, vol. 12, 25 March 2007 (2007-03-25), pages 100 - 101, XP008134326
HIDEMASA OU: "Hito Shinzonai Kansaibo o Mochiita Jika Saibo Ishoku ni yoru Shinkin Saisei Iryo", REGENERATIVE MEDICINE, vol. 7, 22 February 2008 (2008-02-22), pages 160, XP008134325
SCHUPPAN, D. ET AL., GASTROENTEROLOGY, vol. 114, 1998, pages 139
NATURE, vol. 342, 1989, pages 440
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 163, 1989, pages 697
See also references of EP 2210622A4
HIDEMASA OU: "Hito Shinzonai Kansaibo o Mochiita Jika Saibo Ishoku ni yoru Shinkin Saisei Iryo", REGENERATIVE MEDICINE, vol. 7, 22 February 2008 (2008-02-22), pages 160, XP008134325
SCHUPPAN, D. ET AL., GASTROENTEROLOGY, vol. 114, 1998, pages 139
NATURE, vol. 342, 1989, pages 440
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 163, 1989, pages 697
See also references of EP 2210622A4
Attorney, Agent or Firm:
OHNO, Seiji et al. (Kasumigaseki Building 36F 2-5,Kasumigaseki 3-chome,Chiyoda-k, Tokyo 36, JP)
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