Title:
THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASES
Document Type and Number:
WIPO Patent Application WO/2018/199109
Kind Code:
A1
Abstract:
Provided is a therapeutic agent, a preventive agent, or the like that is for diseases caused by accumulation of abnormal protein and that contains a compound represented by general formula (I) (in the formula, R1 and R2 each represent a hydrogen atom or a hydroxyl group (either R1 or R2 is a hydroxyl group)).
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Inventors:
ADACHI HIROAKI (JP)
HUANG ZHE (JP)
HUANG ZHE (JP)
Application Number:
PCT/JP2018/016668
Publication Date:
November 01, 2018
Filing Date:
April 24, 2018
Export Citation:
Assignee:
UNIV OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH JAPAN (JP)
International Classes:
A61K31/352; A61P1/04; A61P21/02; A61P25/08; A61P25/14; A61P25/16; A61P25/28
Domestic Patent References:
| WO2015004475A2 | 2015-01-15 |
Foreign References:
| JP2014214139A | 2014-11-17 | |||
| JP2014122186A | 2014-07-03 | |||
| JP2009124996A | 2009-06-11 | |||
| KR20170106546A | 2017-09-21 |
Other References:
FILOMENI, GIUSEPPE ET AL.: "Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease", NEUROBIOLOGY OF AGING, vol. 33, 2012, pages 767 - 785, XP055527562
VARSHNEY, RITU ET AL.: "Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic beta- cell death through modulation of autophagy via AMPK/mTOR signaling pathway", MOL. CELL . ENDOCRINOL., vol. 448, 15 June 2017 (2017-06-15), pages 1 - 20, XP029982684
LAGOA, RICARDO ET AL.: "Kaempferol protects against rat striatal degeneration induced by 3-nitropropionic acid", JOURNAL OF NEUROCHEMISTRY, vol. 111, no. 2, October 2009 (2009-10-01), pages 473 - 487, XP055527566
DIGALEH, H. ET AL.: "Regulatory impact of luteoline on mitochondrial enzymatic elements and potassium channels of PC12 cells", NEURODENER. DIS., vol. 15, no. 352-1969, 2015, pages 551
ISHIHARA, TOMOE ET AL.: "Analysis of autophagy-inducing mechanism by means of flavonoids", LECTURE ABSTRACTS IN MEETING OF JAPAN SOCIETY OF BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 5 March 2012 (2012-03-05), pages 464
XU, JIANGUO ET AL.: "Posttraumatic administration of luteolin protects mice from traumatic brain injury:implication of autophagy and inflammation", BRAIN RESEARCH, vol. 1582, 25 September 2014 (2014-09-25), pages 237 - 246, XP029055130
EL-HORANY, HEMAT E. ET AL.: "Ameliorative effect of quercetin on neurochemical and behavioral deficits in rotenone rat model of Parkinson's disease:modulating autophagy (quercetin on experimental Parkinson's disease)", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, vol. 30, no. 7, July 2016 (2016-07-01), pages 360 - 369, XP055527581
SANDHIR, RAJAT ET AL.: "Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-ni tropropionic acid: implications in Huntington's disease", BIOCHIMICA ET BIOPHYSICA ACTA (BBA), vol. 1832, no. 3, March 2013 (2013-03-01), pages 421 - 430, XP055527585
HAMABUCHI, NATSUMI ET AL.: "Symptom-mitigating effects of antioxidant in Huntington's disease model mouse", PDF ABSTRACTS OF THE 32TH THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, vol. 3, 2009, pages 237
NAJAFZADEH, MOJGAN ET AL.: "Flavonoids inhibit the genotoxicity of hydrogen peroxide (H202) and of the food mutagen 2-amino-3-methylimadazo [4,5-f]-quinoline (IQ) in lymphocytes from patients with inflammatory bowel disease (IBD)", MUTAGENESIS, vol. 24, no. 5, September 2009 (2009-09-01), pages 405 - 411, XP055527592
VARSHNEY, RITU ET AL.: "Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic beta- cell death through modulation of autophagy via AMPK/mTOR signaling pathway", MOL. CELL . ENDOCRINOL., vol. 448, 15 June 2017 (2017-06-15), pages 1 - 20, XP029982684
LAGOA, RICARDO ET AL.: "Kaempferol protects against rat striatal degeneration induced by 3-nitropropionic acid", JOURNAL OF NEUROCHEMISTRY, vol. 111, no. 2, October 2009 (2009-10-01), pages 473 - 487, XP055527566
DIGALEH, H. ET AL.: "Regulatory impact of luteoline on mitochondrial enzymatic elements and potassium channels of PC12 cells", NEURODENER. DIS., vol. 15, no. 352-1969, 2015, pages 551
ISHIHARA, TOMOE ET AL.: "Analysis of autophagy-inducing mechanism by means of flavonoids", LECTURE ABSTRACTS IN MEETING OF JAPAN SOCIETY OF BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 5 March 2012 (2012-03-05), pages 464
XU, JIANGUO ET AL.: "Posttraumatic administration of luteolin protects mice from traumatic brain injury:implication of autophagy and inflammation", BRAIN RESEARCH, vol. 1582, 25 September 2014 (2014-09-25), pages 237 - 246, XP029055130
EL-HORANY, HEMAT E. ET AL.: "Ameliorative effect of quercetin on neurochemical and behavioral deficits in rotenone rat model of Parkinson's disease:modulating autophagy (quercetin on experimental Parkinson's disease)", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, vol. 30, no. 7, July 2016 (2016-07-01), pages 360 - 369, XP055527581
SANDHIR, RAJAT ET AL.: "Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-ni tropropionic acid: implications in Huntington's disease", BIOCHIMICA ET BIOPHYSICA ACTA (BBA), vol. 1832, no. 3, March 2013 (2013-03-01), pages 421 - 430, XP055527585
HAMABUCHI, NATSUMI ET AL.: "Symptom-mitigating effects of antioxidant in Huntington's disease model mouse", PDF ABSTRACTS OF THE 32TH THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, vol. 3, 2009, pages 237
NAJAFZADEH, MOJGAN ET AL.: "Flavonoids inhibit the genotoxicity of hydrogen peroxide (H202) and of the food mutagen 2-amino-3-methylimadazo [4,5-f]-quinoline (IQ) in lymphocytes from patients with inflammatory bowel disease (IBD)", MUTAGENESIS, vol. 24, no. 5, September 2009 (2009-09-01), pages 405 - 411, XP055527592
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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