Title:
THERAPEUTIC AGENT FOR NON-ALCOHOLIC FATTY LIVER DISEASE, AND SCREENING METHOD FOR DRUG CANDIDATE COMPOUND FOR TREATMENT OR PREVENTION OF NON-ALCOHOLIC FATTY LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2006/104136
Kind Code:
A1
Abstract:
A therapeutic agent for a non-alcoholic fatty liver disease comprising a melanin-concentrating hormone receptor antagonist as an active ingredient, which is developed based on a novel mechanism of action that a melanin-concentrating hormone receptor is involved in non-alcoholic fatty liver diseases. A method for screening a drug candidate compound for the treatment or prevention of a non-alcoholic fatty liver disease by utilizing the mechanism.
Inventors:
GOMORI AKIRA (JP)
ISHIHARA AKANE (JP)
IWAASA HISASHI (JP)
SUZUKI JUN (JP)
ITO MAKOTO (JP)
KANATANI AKIO (JP)
ISHIHARA AKANE (JP)
IWAASA HISASHI (JP)
SUZUKI JUN (JP)
ITO MAKOTO (JP)
KANATANI AKIO (JP)
Application Number:
PCT/JP2006/306258
Publication Date:
October 05, 2006
Filing Date:
March 28, 2006
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
GOMORI AKIRA (JP)
ISHIHARA AKANE (JP)
IWAASA HISASHI (JP)
SUZUKI JUN (JP)
ITO MAKOTO (JP)
KANATANI AKIO (JP)
GOMORI AKIRA (JP)
ISHIHARA AKANE (JP)
IWAASA HISASHI (JP)
SUZUKI JUN (JP)
ITO MAKOTO (JP)
KANATANI AKIO (JP)
International Classes:
A61P1/16; A61K45/00; A61P43/00; G01N33/15; G01N33/50; G01N33/566
Domestic Patent References:
| WO2004002987A1 | 2004-01-08 | |||
| WO2004031177A1 | 2004-04-15 | |||
| WO2004011440A1 | 2004-02-05 |
Foreign References:
| JP2005507918A | 2005-03-24 |
Other References:
CHEN Y. ET AL.: "Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity", ENDOCRINOLOGY, vol. 143, no. 7, 2002, pages 2469 - 2477, XP003002882
SHIMADA M. ET AL.: "Mice lacking melanin-concentrating hormone are hypophagic and lean", NATURE, vol. 396, 1998, pages 670 - 674, XP002308086
FUNAKOSHI A. ET AL.: "Himan ni Kiin Kanren suru kakushu Byotai to Seiritsu Kijo Kimo Tannou, Suishikkan (Shibokan, Tanseki, Suien)", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 61, no. 6, 2003, pages 479 - 484, XP003002883
See also references of EP 1867341A4
SHIMADA M. ET AL.: "Mice lacking melanin-concentrating hormone are hypophagic and lean", NATURE, vol. 396, 1998, pages 670 - 674, XP002308086
FUNAKOSHI A. ET AL.: "Himan ni Kiin Kanren suru kakushu Byotai to Seiritsu Kijo Kimo Tannou, Suishikkan (Shibokan, Tanseki, Suien)", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 61, no. 6, 2003, pages 479 - 484, XP003002883
See also references of EP 1867341A4
Attorney, Agent or Firm:
Hasegawa, Yoshiki (Ginza First Bldg. 10-6, Ginza 1-chom, Chuo-ku Tokyo 61, JP)
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