Title:
THERAPEUTIC AGENT FOR PULMONARY FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2023/008402
Kind Code:
A1
Abstract:
It was discovered that macrophages in which the SLC15A3 gene has been knocked out have an excellent therapeutic effect against pulmonary fibrosis.
Inventors:
SORIMACHI NORIKO (JP)
KOBAYASHI TOSHIHIKO (JP)
NGUYEN TIEN DAT (JP)
KOBAYASHI TOSHIHIKO (JP)
NGUYEN TIEN DAT (JP)
Application Number:
PCT/JP2022/028695
Publication Date:
February 02, 2023
Filing Date:
July 26, 2022
Export Citation:
Assignee:
NAT CENTER FOR GLOBAL HEALTH AND MEDICINE (JP)
International Classes:
A61K35/15; A61P11/00; C12N5/0786
Other References:
KOBAYASHI TOSHIHIKO: "Role of lysosome-resident amino acid transporters in inflammatory response", GRANT-IN-AID FOR SCIENTIFIC RESEARCH, FINAL RESEARCH REPORT, 7 June 2021 (2021-06-07), XP093029210, Retrieved from the Internet [retrieved on 20230306]
KOBAYASHI TOSHIHIKO: "Role of lysosome-localized amino acid transporters in regulation of inflammatory response", 2019 IMPLEMENTATION STATUS REPORT, 27 January 2021 (2021-01-27), XP093029212, Retrieved from the Internet
SCHWARZ MARVIN I.: "Diffuse alveolar hemorrhage ", MSD MANUAL PROFESSIONAL VERSION, 1 December 2018 (2018-12-01), XP093029214, Retrieved from the Internet [retrieved on 20230306]
KOBAYASHI TOSHIHIKO: "Construction of inflammatory cell society and pulmonary fibrosis mechanism mediated by amino acid transporter SLC15A3", KAKEN, 27 December 2021 (2021-12-27), XP093029217, Retrieved from the Internet [retrieved on 20230306]
KOBAYASHI TOSHIHIKO: "Role of lysosome-localized amino acid transporters in regulation of inflammatory response", 2019 IMPLEMENTATION STATUS REPORT, 27 January 2021 (2021-01-27), XP093029212, Retrieved from the Internet
SCHWARZ MARVIN I.: "Diffuse alveolar hemorrhage ", MSD MANUAL PROFESSIONAL VERSION, 1 December 2018 (2018-12-01), XP093029214, Retrieved from the Internet
KOBAYASHI TOSHIHIKO: "Construction of inflammatory cell society and pulmonary fibrosis mechanism mediated by amino acid transporter SLC15A3", KAKEN, 27 December 2021 (2021-12-27), XP093029217, Retrieved from the Internet
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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