Title:
THERAPEUTIC AGENT FOR REFRACTORY VIRAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2023/085440
Kind Code:
A1
Abstract:
Provided is a therapeutic agent or the like that is for refractory viral infections and that is capable of eliminating or decreasing cccDNA in hepatocytes. This therapeutic agent for refractory viral infections according to the present invention is characterized by comprising a composite which includes, in a drug carrier useful for delivering a drug into cells, poly-I or a poly-I analog, and poly-C or a poly-C analog, and in which a molecule for providing the ability to accumulate to hepatocytes is conjugated on the surface of the carrier.
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Inventors:
KOHARA MICHIHIRO (JP)
YAMAMOTO NAOKI (JP)
TANAKA YASUHITO (JP)
SATO YUSUKE (JP)
YAMAMOTO NAOKI (JP)
TANAKA YASUHITO (JP)
SATO YUSUKE (JP)
Application Number:
PCT/JP2022/042459
Publication Date:
May 19, 2023
Filing Date:
November 09, 2022
Export Citation:
Assignee:
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
A61K31/7088; A61K38/21; A61K45/00; A61K47/24; A61K47/69; A61P1/16; A61P31/12; A61P31/20; A61P37/04; A61P43/00; C12N15/117
Foreign References:
| JP2012056896A | 2012-03-22 |
Other References:
DU YANQIN; YANG XIAOLI; LI JIA; SOKOLOVA VIKTORIYA; ZOU SHI; HAN MEIHONG; YAN HU; WEY KAROLIN; LU MENGJI; DITTMER ULF; YANG DONGLI: "Delivery of toll-like receptor 3 ligand poly(I:C) to the liver by calcium phosphate nanoparticles conjugated with an F4/80 antibody exerts an anti-hepatitis B virus effect in a mouse model", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 133, 1 February 2021 (2021-02-01), AMSTERDAM, NL, pages 297 - 307, XP086811421, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2021.01.045
KOMAL ASMA; NOREEN MAMOONA; EL-KOTT ATTALLA F.: "TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review", IMMUNOLOGY RESEARCH, HUMANA PRESS, INC, US, vol. 69, no. 4, 19 June 2021 (2021-06-19), US , pages 312 - 322, XP037530922, ISSN: 0257-277X, DOI: 10.1007/s12026-021-09203-6
HASHIMOTO SHINICHI, SHIRASAKI TAKAYOSHI, YAMASHITA TARO, IWABUCHI SADAHIRO, SUZUKI YUTAKA, TAKAMURA YUZURU, UKITA YOSHIAKI, DESHIM: "DOCK11 and DENND2A play pivotal roles in the maintenance of hepatitis B virus in host cells", PLOS ONE, vol. 16, no. 2, pages e0246313, XP093065561, DOI: 10.1371/journal.pone.0246313
SATO YUSUKE; MATSUI HIDEKI; YAMAMOTO NAOKI; SATO RISA; MUNAKATA TSUBASA; KOHARA MICHINORI; HARASHIMA HIDEYOSHI: "Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 266, 3 October 2017 (2017-10-03), AMSTERDAM, NL , pages 216 - 225, XP085292714, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.09.044
KOMAL ASMA; NOREEN MAMOONA; EL-KOTT ATTALLA F.: "TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review", IMMUNOLOGY RESEARCH, HUMANA PRESS, INC, US, vol. 69, no. 4, 19 June 2021 (2021-06-19), US , pages 312 - 322, XP037530922, ISSN: 0257-277X, DOI: 10.1007/s12026-021-09203-6
HASHIMOTO SHINICHI, SHIRASAKI TAKAYOSHI, YAMASHITA TARO, IWABUCHI SADAHIRO, SUZUKI YUTAKA, TAKAMURA YUZURU, UKITA YOSHIAKI, DESHIM: "DOCK11 and DENND2A play pivotal roles in the maintenance of hepatitis B virus in host cells", PLOS ONE, vol. 16, no. 2, pages e0246313, XP093065561, DOI: 10.1371/journal.pone.0246313
SATO YUSUKE; MATSUI HIDEKI; YAMAMOTO NAOKI; SATO RISA; MUNAKATA TSUBASA; KOHARA MICHINORI; HARASHIMA HIDEYOSHI: "Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 266, 3 October 2017 (2017-10-03), AMSTERDAM, NL , pages 216 - 225, XP085292714, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.09.044
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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