Title:
THERAPEUTIC AND/OR AMELIORATING AGENT FOR DISSEMINATED INTRAVASCULAR COAGULATION
Document Type and Number:
WIPO Patent Application WO/2008/044631
Kind Code:
A1
Abstract:
Disclosed is a therapeutic and/or ameliorating agent or a therapy and/or amelioration method for disseminated intravascular coagulation (DIC) which has a higher therapeutic effect. Specifically disclosed is a therapeutic and/or prophylactic agent for DIC, which comprises thrombomodurin as an active ingredient. The therapeutic and/or prophylactic agent is administered to a patient having a decreased anti-thrombin level, namely a patient having an activation value of anti-thrombin in the plasma of less than 50%.
Inventors:
AOKI YOSHIKAZU (JP)
Application Number:
PCT/JP2007/069560
Publication Date:
April 17, 2008
Filing Date:
October 05, 2007
Export Citation:
Assignee:
ASAHI KASEI PHARMA CORP (JP)
AOKI YOSHIKAZU (JP)
AOKI YOSHIKAZU (JP)
International Classes:
A61K38/00; A61P7/02; C07K14/745; C12N15/00
Domestic Patent References:
| WO1992000325A1 | 1992-01-09 | |||
| WO1992003149A1 | 1992-03-05 | |||
| WO1993015755A1 | 1993-08-19 | |||
| WO1988009811A1 | 1988-12-15 |
Foreign References:
| JPS646219U | 1989-01-13 | |||
| JPH02255699A | 1990-10-16 | |||
| JPH03133380A | 1991-06-06 | |||
| JPH03259084A | 1991-11-19 | |||
| JPH04210700A | 1992-07-31 | |||
| JPH05213998A | 1993-08-24 | |||
| JPH0386900A | 1991-04-11 | |||
| JPH03218399A | 1991-09-25 | |||
| JPH11341990A | 1999-12-14 | |||
| JPH05310787A | 1993-11-22 | |||
| JPH07155176A | 1995-06-20 | |||
| JPH0542920B2 | 1993-06-30 | |||
| JPS6445398U | 1989-03-20 | |||
| JPH06205692A | 1994-07-26 | |||
| JPH09110900A | 1997-04-28 |
Other References:
IMADA K. ET AL.: "ATIII-independence of anticoagulant effect of human urinary soluble thrombomodulin", BLOOD COAGUL FIBRINOLYSIS, vol. 10, no. 8, December 1999 (1999-12-01), pages 503 - 511, XP008104867
AOKI Y. ET AL.: "Effects of recombinant human soluble thrombomodulin (rhm) on a rat model of disseminated intravascular coagulation with decreased levels of plasma antithrombin III", THROMB. HAEMOST., vol. 71, no. 4, April 1994 (1994-04-01), pages 452 - 455, XP008104868
KOJI SUZUKI, IGAKU NO AYUMI, vol. 125, 1983, pages 901
K. GOMI ET AL., BLOOD, vol. 75, 1990, pages 1396 - 1399
M. ZUSHI ET AL., J. BIOL. CHEM., vol. 246, 1989, pages 10351 - 10353
D. Z. WEN ET AL., BIOCHEMISTRY, vol. 26, 1987, pages 4350 - 4357
S. M. BATES ET AL., BR. J. OFPHARMACOL., vol. 144, 2005, pages 1017 - 1028
MAJERUS PW; TOLLEFSEN DM: "Goodman & Gilman's The Pharmacological Basis of Therapeutics", 2003, HIROKAWA SHOTEN, CO., article "Coagulants, thrombolytic agents, and anti-platelet agents", pages: 1937 - 1963
KENJI OKAJIMA: "Medicine and Drug", JOURNAL CO., LTD., article "Hanshusei kekkannai gyoko shokogun to tazoki fuzen (Disseminated intravascular coagulation syndrome and multiple organ failure)"
MASAO NAKAGAWA: "Search report regarding use of criteria of disseminated intravascular coagulation (DIC)", RESEARCH STUDY TEAM OF INTRACTABLE DISEASE, 1999, pages 65 - 72
KATSUMI DEGUCHI: "Tentative plan regarding standards for initiation of early treatment of DIC", RESEARCH STUDY TEAM OF INTRACTABLE DISEASE (BLOOD COAGULATION ABNORMALITY), 1999, pages 73 - 77
KATSUMI; NAKAGAWA; HAJIME TSUJI: "Current diagnosis of DIC - Reports on results of inquiry survey", CLINICAL BLOOD, vol. 40, 1999, pages 362 - 364
TAYLOR FB ET AL., THROMB HAEMOST, vol. 86, 2001, pages 1327 - 1330
GANDO S. ET AL., CLIN APPL THROMB HEMOST, vol. 11, no. 1, 2005, pages 71 - 76
NOBUO AOKI; JUN HASEGAWA: "Revision of the chapter 'Auxiliary test results and findings for the diagnosis' in DIC criteria", RESEARCH STUDY TEAM OF INTRACTABLE DISEASE (BLOOD COAGULATION ABNORMALITY), 1988, pages 37 - 41
LEVY M. ET AL., CRIT CARE. MED., vol. 31, pages 1250 - 1256
CRIT CARE MED, vol. 20, 1992, pages 864 - 874
"Harrison's Principles of Internal Medicine", vol. 124, pages: 828 - 833
R C. MULLIGAN ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 78, 1981, pages 2072
P. M. HOWLEY ET AL.: "Methods in Emzymology", vol. 101, 1983, ACADEMIC PRESS, pages: 387
J. BIOL. CHEM., vol. 264, 1989, pages 10351 - 10353
"Method in Enzymology", vol. 100, 1983, ACADEMIC PRESS, pages: 468
GOMI K. ET AL., BLOOD, vol. 75, 1990, pages 1396 - 1399
See also references of EP 2062589A4
AOKI Y. ET AL.: "Effects of recombinant human soluble thrombomodulin (rhm) on a rat model of disseminated intravascular coagulation with decreased levels of plasma antithrombin III", THROMB. HAEMOST., vol. 71, no. 4, April 1994 (1994-04-01), pages 452 - 455, XP008104868
KOJI SUZUKI, IGAKU NO AYUMI, vol. 125, 1983, pages 901
K. GOMI ET AL., BLOOD, vol. 75, 1990, pages 1396 - 1399
M. ZUSHI ET AL., J. BIOL. CHEM., vol. 246, 1989, pages 10351 - 10353
D. Z. WEN ET AL., BIOCHEMISTRY, vol. 26, 1987, pages 4350 - 4357
S. M. BATES ET AL., BR. J. OFPHARMACOL., vol. 144, 2005, pages 1017 - 1028
MAJERUS PW; TOLLEFSEN DM: "Goodman & Gilman's The Pharmacological Basis of Therapeutics", 2003, HIROKAWA SHOTEN, CO., article "Coagulants, thrombolytic agents, and anti-platelet agents", pages: 1937 - 1963
KENJI OKAJIMA: "Medicine and Drug", JOURNAL CO., LTD., article "Hanshusei kekkannai gyoko shokogun to tazoki fuzen (Disseminated intravascular coagulation syndrome and multiple organ failure)"
MASAO NAKAGAWA: "Search report regarding use of criteria of disseminated intravascular coagulation (DIC)", RESEARCH STUDY TEAM OF INTRACTABLE DISEASE, 1999, pages 65 - 72
KATSUMI DEGUCHI: "Tentative plan regarding standards for initiation of early treatment of DIC", RESEARCH STUDY TEAM OF INTRACTABLE DISEASE (BLOOD COAGULATION ABNORMALITY), 1999, pages 73 - 77
KATSUMI; NAKAGAWA; HAJIME TSUJI: "Current diagnosis of DIC - Reports on results of inquiry survey", CLINICAL BLOOD, vol. 40, 1999, pages 362 - 364
TAYLOR FB ET AL., THROMB HAEMOST, vol. 86, 2001, pages 1327 - 1330
GANDO S. ET AL., CLIN APPL THROMB HEMOST, vol. 11, no. 1, 2005, pages 71 - 76
NOBUO AOKI; JUN HASEGAWA: "Revision of the chapter 'Auxiliary test results and findings for the diagnosis' in DIC criteria", RESEARCH STUDY TEAM OF INTRACTABLE DISEASE (BLOOD COAGULATION ABNORMALITY), 1988, pages 37 - 41
LEVY M. ET AL., CRIT CARE. MED., vol. 31, pages 1250 - 1256
CRIT CARE MED, vol. 20, 1992, pages 864 - 874
"Harrison's Principles of Internal Medicine", vol. 124, pages: 828 - 833
R C. MULLIGAN ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 78, 1981, pages 2072
P. M. HOWLEY ET AL.: "Methods in Emzymology", vol. 101, 1983, ACADEMIC PRESS, pages: 387
J. BIOL. CHEM., vol. 264, 1989, pages 10351 - 10353
"Method in Enzymology", vol. 100, 1983, ACADEMIC PRESS, pages: 468
GOMI K. ET AL., BLOOD, vol. 75, 1990, pages 1396 - 1399
See also references of EP 2062589A4
Attorney, Agent or Firm:
SIKs & Co. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi1-chome, Chuo-k, Tokyo 31, JP)
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