Title:
THERAPEUTIC OR PROPHYLACTIC FOR HTLV-1-ASSOCIATED MYELOPATHY (HAM), THERAPEUTIC EFFICACY DETERMINATION METHOD, AND ACTIVITY EVALUATION METHOD OR DIAGNOSIS METHOD
Document Type and Number:
WIPO Patent Application WO/2023/080157
Kind Code:
A1
Abstract:
The present invention pertains to a therapeutic or prophylactic for HTLV-1-associated myelopathy (HAM), said therapeutic or prophylactic including a substance that inhibit the activity of the MAPK signaling pathway in which mitogen-activated protein kinase kinase kinase 8 (MAP3K8) is involved.
Inventors:
UCHIMARU KAORU (JP)
YAMAGISHI MAKOTO (JP)
NAGAI KAHO (JP)
YAMANO YOSHIHISA (JP)
YAMAGISHI MAKOTO (JP)
NAGAI KAHO (JP)
YAMANO YOSHIHISA (JP)
Application Number:
PCT/JP2022/040989
Publication Date:
May 11, 2023
Filing Date:
November 02, 2022
Export Citation:
Assignee:
UNIV TOKYO (JP)
UNIV SCHOOL ST MARIANNA MEDICINE (JP)
UNIV SCHOOL ST MARIANNA MEDICINE (JP)
International Classes:
A61K45/00; A61P25/00; A61P31/14; G01N33/573
Domestic Patent References:
| WO2018025923A1 | 2018-02-08 |
Foreign References:
| JP2007277223A | 2007-10-25 | |||
| US20120289418A1 | 2012-11-15 |
Other References:
LÜSCHEN SILKE, SCHERER GUDRUN, USSAT SANDRA, UNGEFROREN HENDRIK, ADAM-KLAGES SABINE: "Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-κB, elicits caspase activity, and enhances cytotoxicity", EXPERIMENTAL CELL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 293, no. 2, 1 February 2004 (2004-02-01), AMSTERDAM, NL , pages 196 - 206, XP093062917, ISSN: 0014-4827, DOI: 10.1016/j.yexcr.2003.10.009
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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