THIAZOLECARBOXAMIDINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Title:

THIAZOLECARBOXAMIDINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/025070

Kind Code:

A1

Abstract:

Provided are a thiazolecarboxamidine compound, and a preparation method therefor and the use thereof. The thiazolecarboxamidine compound is represented by the following general formula (I). The compound is a mitochondrial complex I inhibitor and can be used for treating tumors.

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Inventors:

LIU JIYUAN (CN)
ZHANG YALIN (CN)

Application Number:

PCT/CN2022/113805

Publication Date:

March 02, 2023

Filing Date:

August 22, 2022

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Assignee:

NORTHWEST A & F UNIV (CN)

International Classes:

C07D275/03; A61K31/425; A61P35/00

Domestic Patent References:

WO2005070889A1

2005-08-04

Foreign References:

CN104936956A

2015-09-23

Other References:

DATABASE REGISTRY ANONYMOUS : "4-Isothiazolecarboxamide, N-[1-(2,4,6-trifluorophenyl)ethyl]- (CA INDEX NAME) ", XP093038535, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "4-Isothiazolecarboxamide, 3-methyl-N-[[4-(2-oxo-1- pyrrolidinyl)phenyl]methyl]-(CA INDEX NAME)", XP093038536, retrieved from STN

Attorney, Agent or Firm:

BEIJING MOUNTAINWILL INTELLECTUAL PROPERTY AGENCY (CN)

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