THIENOPYRIMIDINE COMPOUNDS AND THEIR SALTS AND PROCESS FOR PREPARATION OF BOTH

WIPO Patent Application WO/2002/026745

A1

The invention relates to novel thienopyrimidine compounds useful as drugs having a cGMP-specific phosphodiesterase inhibiting effect or the like, specifically thieno[2,3-d]- pyrimidine compounds of the general formula (1), and a process for preparing the same: (1) wherein R¿1? is hydrogen or C¿1-6? alkyl; R¿2? is optionally substituted C¿3-8? cycloalkyl, optionally substituted phenyl, or an optionally substituted saturated or unsaturated heterocyclic group containing one to four heteroatoms selected from among N, O and S; R¿3? is an optionally substituted saturated or unsaturated heterocyclic group containing one to four heteroatoms selected from among N, O and S, (CH¿2?)¿K?C(=O)R¿6?, or CH=CHC(=O)R¿6?; R¿4? is hydrogen, C¿1-6? alkyl, hydroxyl, C¿1-6? alkoxy, halogeno, C¿1-6? haloalkyl, nitro, or cyano; and R¿5? is cyano, optionally substituted phenyl, an optionally substituted saturated or unsaturated heterocyclic group containing one to four heteroatoms selected from among N, O and S, or the like.

UMEDA NOBUHIRO (JP)
TAKADA MITSUMASA (JP)
IKEYAMA SEIICHI (JP)
ICHIKAWA KIMIKO (JP)

PCT/JP2001/008530

April 04, 2002

September 28, 2001

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NIPPON SODA CO (JP)
UMEDA NOBUHIRO (JP)
TAKADA MITSUMASA (JP)
IKEYAMA SEIICHI (JP)
ICHIKAWA KIMIKO (JP)

A61P43/00; C07D495/04; (IPC1-7): C07D495/04; A61K31/519; A61K31/5377; A61P43/00

WO1998017668A1	1998-04-30
WO1998006722A1	1998-02-19
WO1999028325A1	1999-06-10

EP0728759A1

1996-08-28

Tokai, Yusaku c/o Nippon Soda Co. (Ltd. 2-1 Ohtemachi 2-chome Chiyoda-ku, Tokyo, JP)

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