Title:
THIOPEPTIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2007/049582
Kind Code:
A1
Abstract:
It is intended to provide a novel thiopeptide compound represented by the formula (I)
obtained by subjecting a known thiopeptide compound QN3323-A substance to oximation
and acylation at the 2- and 26-positions and a salt thereof. The compound has a
good antimicrobial activity, particularly has an excellent antimicrobial activity
against multidrug resistant bacteria such as MRSA and VRE, and is useful as a pharmaceutical,
particularly an antimicrobial agent, more particularly a preventive and/or
therapeutic agent for multidrug resistant bacterial infection. (I) In the formula,
the symbols have the following meaning. R1 represents lower alkyl
which may have a substituent or the like; R2 represents -ALK-COORa,
-ALK- (heteroaryl which may have a substituent), -ALK- (aryl which may have a
substituent), or -ALK-NRbRc; ALK represents a lower alkylene group; Ra represents
H or lower alkyl; Rb and Rc are the same or different, and represent H or lower alkyl
or are combined with the adjacent nitrogen atom to form a 5- to 8-membered nitrogen-containing
saturated cyclic group which may have a substituent.
Inventors:
KAZAMI JUNICHI (JP)
OGIYAMA TAKASHI (JP)
WATANABE MASATO (JP)
KAMIGIRI KAZUMA (JP)
YAMAGUCHI TAKASHI (JP)
TATSUTA KUNIAKI (JP)
OGIYAMA TAKASHI (JP)
WATANABE MASATO (JP)
KAMIGIRI KAZUMA (JP)
YAMAGUCHI TAKASHI (JP)
TATSUTA KUNIAKI (JP)
Application Number:
PCT/JP2006/321107
Publication Date:
May 03, 2007
Filing Date:
October 24, 2006
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
UNIV WASEDA (JP)
KAZAMI JUNICHI (JP)
OGIYAMA TAKASHI (JP)
WATANABE MASATO (JP)
KAMIGIRI KAZUMA (JP)
YAMAGUCHI TAKASHI (JP)
TATSUTA KUNIAKI (JP)
UNIV WASEDA (JP)
KAZAMI JUNICHI (JP)
OGIYAMA TAKASHI (JP)
WATANABE MASATO (JP)
KAMIGIRI KAZUMA (JP)
YAMAGUCHI TAKASHI (JP)
TATSUTA KUNIAKI (JP)
International Classes:
C07D513/22; A61K31/437; A61K31/4709; A61K31/496; A61K31/5377; A61P31/04
Domestic Patent References:
| WO2002072617A1 | 2002-09-19 |
Other References:
BYCROFT B.W. ET AL.: "The structures of the highly modified peptide antibiotics micrococcin P1 and P2", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, no. 6, 1978, pages 256 - 258, XP002043056
SASAKI T. ET AL.: "MJ347-81F4 A & B, Novel Antibiotics from Amycolatopsis sp.: Taxonomic Characteristics, Fermentation, and Antimicrobial Activity", JOURNAL OF ANTIBIOTICS, vol. 51, no. 8, 1998, pages 715 - 721, XP002919932
SASAKI T. ET AL.: "MJ347-81F4 A & B, Novel Antibiotics from Amycolatopsis sp.: Taxonomic Characteristics, Fermentation, and Antimicrobial Activity", JOURNAL OF ANTIBIOTICS, vol. 51, no. 8, 1998, pages 715 - 721, XP002919932
Attorney, Agent or Firm:
SHOJI, Takashi (2-10 Iwamotocho 3-chom, Chiyoda-ku Tokyo 32, JP)
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