TPO MIMETIC FUSION PROTEINS AND METHODS OF USE SUBMISSION OF SEQUENCE LISTING AS ASCII TEXT FILE

Title:

TPO MIMETIC FUSION PROTEINS AND METHODS OF USE SUBMISSION OF SEQUENCE LISTING AS ASCII TEXT FILE

Document Type and Number:

WIPO Patent Application WO/2023/044774

Kind Code:

A1

Abstract:

Provided are recombinant peptides comprising a recombinant human p75 TNF receptor and TPO mimetic peptides linked by an Fc fragment of IgG1. The recombinant peptides can form a homodimer by inter-chain disulfide bond in the Fc region and can have six TPOR binding and/or activating domain in the C-terminus. The recombinant peptides provided herein are useful for increasing platelet count, e.g., for treating thrombocytopenia. Also provided herein are methods for producing the recombinant peptides, formulations and therapeutic methods.

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Inventors:

LIANG PENG (CN)

Application Number:

PCT/CN2021/120388

Publication Date:

March 30, 2023

Filing Date:

September 24, 2021

Export Citation:

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Assignee:

SICHUAN CLOVER BIOPHARMACEUTICALS INC (CN)

International Classes:

C07K19/00; A61K38/16; A61P7/04; C12N15/62; C12N15/64; C12N15/86

Domestic Patent References:

WO2003024384A2

2003-03-27

Foreign References:

CN101103045A	2008-01-09
CN112494658A	2021-03-16
CN102382850A	2012-03-21
CN1325447A	2001-12-05

Attorney, Agent or Firm:

MERITS & TREE (CN)

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