Title:
TRADITIONAL CHINESE MEDICINE COMPOSITION FOR TREATING CARDIOVASCULAR AND CEREBROVASCULAR DISEASE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/200768
Kind Code:
A1
Abstract:
A traditional Chinese medicine composition for treating cardiovascular and cerebrovascular disease, the active ingredients thereof being composed of: 1) an ethanol extract of 6-12 parts of Ligusticum wallichii and 5-10 parts of Curcumae Radix, and 2) an aqueous extract of extract residue of the described Ligusticum wallichii and Curcumae Radix and 5-10 parts of Achyranthes bidentata; the traditional Chinese medicine composition may further comprise an aqueous extract of 5-10 parts of Allium macrostemon and 6-12 parts of Eucommia ulmoides. The traditional Chinese medicine composition relates to medicine made from plant compounds, and has significant medicinal effects on myocardial contraction disorder and myocardial dilation disorder, platelet aggregation thrombosis and myocardial ischemia, myocardial hypoxia, myocardial fatigue, and so on, being particularly suitable for treating coronary heart disease and chronic or acute heart failure.
Inventors:
JIA HONGZHANG (CN)
Application Number:
PCT/CN2018/096673
Publication Date:
October 24, 2019
Filing Date:
July 23, 2018
Export Citation:
Assignee:
JIA HONGZHANG (CN)
International Classes:
A61K36/9066; A61P7/02; A61P9/04; A61P9/10
Foreign References:
| CN1788785A | 2006-06-21 | |||
| CN1480160A | 2004-03-10 | |||
| CN101474219A | 2009-07-08 | |||
| CN1197654A | 1998-11-04 | |||
| CN103007185A | 2013-04-03 | |||
| CN1679832A | 2005-10-12 | |||
| CN103933474A | 2014-07-23 |
Other References:
NAGUEH, SHERIF F. ET AL.: "Recommendations for the evaluation of left ventricular diastolic function by echocardiography", JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, vol. 22, no. 2, 2009, pages 107 - 133
SOLOMON, SCOTT D. ET AL.: "he angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial", THE LANCET, vol. 380, no. 9851, 2012, pages 1387 - 1395, XP055083562, DOI: 10.1016/S0140-6736(12)61227-6
HANSEN, B. C.N. L. BODKIN: "Heterogeneity of insulin responses: phases leading to type 2 (non-insulin-dependent) diabetes mellitus in the rhesus monkey", DIABETOLOGIA, vol. 29, no. 10, 1986, pages 713 - 719
QIAN, CAN ET AL.: "Diastolic dysfunction in spontaneous type 2 diabetes rhesus monkeys: a study using echocardiography and magnetic resonance imaging", BMC CARDIOVASCULAR DISORDERS, vol. 15, no. 1, 2015, pages 59
JEONG, EUY-MYOUNG ET AL.: "Role of mitochondrial oxidative stress in glucose tolerance, insulin resistance, and cardiac diastolic dysfunction", JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol. 5, no. 5, 2016, pages e003046
See also references of EP 3782635A4
SOLOMON, SCOTT D. ET AL.: "he angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial", THE LANCET, vol. 380, no. 9851, 2012, pages 1387 - 1395, XP055083562, DOI: 10.1016/S0140-6736(12)61227-6
HANSEN, B. C.N. L. BODKIN: "Heterogeneity of insulin responses: phases leading to type 2 (non-insulin-dependent) diabetes mellitus in the rhesus monkey", DIABETOLOGIA, vol. 29, no. 10, 1986, pages 713 - 719
QIAN, CAN ET AL.: "Diastolic dysfunction in spontaneous type 2 diabetes rhesus monkeys: a study using echocardiography and magnetic resonance imaging", BMC CARDIOVASCULAR DISORDERS, vol. 15, no. 1, 2015, pages 59
JEONG, EUY-MYOUNG ET AL.: "Role of mitochondrial oxidative stress in glucose tolerance, insulin resistance, and cardiac diastolic dysfunction", JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol. 5, no. 5, 2016, pages e003046
See also references of EP 3782635A4
Attorney, Agent or Firm:
BEIJING EAST IP LTD. (CN)
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