TRANSGENIC PIG ISLETS AND USES THEREOF FOR TREATING DIABETES

Title:

TRANSGENIC PIG ISLETS AND USES THEREOF FOR TREATING DIABETES

Document Type and Number:

WIPO Patent Application WO/2015/155360

Kind Code:

A8

Abstract:

The present invention relates to an isolated transgenic pig beta cell wherein the PKC and the PKA pathway are constitutively activated; to a transgenic pig islet comprising said transgenic pig beta cell; and to a transgenic pig comprising said transgenic pig beta cell or said transgenic pig islet. Another object of the invention is a device comprising a transgenic pig beta cell or a transgenic pig islet of the invention. The present invention also relates to the use of said transgenic pig beta cell, said transgenic pig islet, or said device for treating a disease, disorder or condition related to the impaired function of endocrine pancreas or of beta cell.

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Inventors:

GIANELLO PIERRE (BE)
MOURAD NIZAR (BE)

Application Number:

PCT/EP2015/057914

Publication Date:

January 10, 2019

Filing Date:

April 10, 2015

Export Citation:

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Assignee:

UNIV CATHOLIQUE LOUVAIN (BE)

International Classes:

C12N5/071; A01K67/027; A61K35/39; A61K48/00

Attorney, Agent or Firm:

ICOSA (FR)

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