Title:
TREATMENT FOR KNEE OSTEOARTHRITIS USING ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELL LINE
Document Type and Number:
WIPO Patent Application WO/2023/085219
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a therapeutic agent using a specific adipose tissue-derived mesenchymal stem cell line (ASCL), etc., said therapeutic agent (i) having a stable and excellent therapeutic effect on one or more diseases selected from knee osteoarthritis, traumatic cartilage defect and osteochondritis dissecans, (ii) loading less physical burden on a patient, (iii) requiring no restriction on patient's hospital visit management, and (iv) having no restriction on the number of treatments. The present invention is characterized by using an adipose tissue-derived mesenchymal stem cell line that is produced by a production method comprising: (A) a step for inducing differentiation of one or more kinds of cells selected from a group of stromal vascular cells, including mesenchymal stem cells, adipose progenitor cells and stromal cells of a vertebrate adipose tissue, into mature adipocytes; and (B) a step for inducing dedifferentiation of the mature adipocytes obtained in step (A) to obtain a vertebrate adipose tissue-derived mesenchymal cell line.
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Inventors:
FUKUDA YOSHITSUGU (JP)
NIKI YASUO (JP)
NAKAMURA MASAYA (JP)
MATSUBARA YUMIKO (JP)
URUGA YUKAKO (JP)
NIKI YASUO (JP)
NAKAMURA MASAYA (JP)
MATSUBARA YUMIKO (JP)
URUGA YUKAKO (JP)
Application Number:
PCT/JP2022/041299
Publication Date:
May 19, 2023
Filing Date:
November 07, 2022
Export Citation:
Assignee:
UNIV KEIO (JP)
International Classes:
A61K35/28; A61P19/02; A61P19/08; A61P29/00; C12N5/0775
Domestic Patent References:
| WO2017094260A1 | 2017-06-08 | |||
| WO2018101481A1 | 2018-06-07 |
Foreign References:
| JP2021080184A | 2021-05-27 | |||
| US20180104280A1 | 2018-04-19 | |||
| JP5991687B2 | 2016-09-14 |
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
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