Title:
TREATMENT OF NEURODEGENERATIVE DISEASES BY THE USE OF ATP7A-MODULATORS
Document Type and Number:
WIPO Patent Application WO2005075632
Kind Code:
A3
Abstract:
The invention relates to the use of a ATP7A-interacting molecule for the preparation of a pharmaceutical composition for the treatment of a neurogenerative disease. Hereby the ATP7A-interacting molecule is preferably an inhibitor of ATP7A and particularly it has the capacity to modulate the activity of gamma-secretase and/or beta-secretase. Furthermore the invention concerns a process for identifying a gamma-secretase and/or a beta-secretase modulator comprising the following steps: a. identifying of a ATP7A-interacting molecule by determining whether a given test compound is a ATP7A-interacting molecule, b. determining whether the ATP7A-interacting molecule of step a) is capable of modulating gamma-secretase and/or beta-secretase activity.
Inventors:
HOPF CARSTEN (DE)
DREWES GERARD (DE)
RUFFNER HEINZ (DE)
DREWES GERARD (DE)
RUFFNER HEINZ (DE)
Application Number:
PCT/EP2004/013538
Publication Date:
November 10, 2005
Filing Date:
November 29, 2004
Export Citation:
Assignee:
CELLZOME AG (DE)
HOPF CARSTEN (DE)
DREWES GERARD (DE)
RUFFNER HEINZ (DE)
HOPF CARSTEN (DE)
DREWES GERARD (DE)
RUFFNER HEINZ (DE)
International Classes:
C12N9/14; C12N15/113; (IPC1-7): C12N9/14; C12N15/11; A61K31/713; C12Q1/34
Domestic Patent References:
| WO1998015828A1 | 1998-04-16 | |||
| WO2001016355A2 | 2001-03-08 |
Other References:
BAYER THOMAS A ET AL: "Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 24, 25 November 2003 (2003-11-25), pages 14187 - 14192, XP002339932, ISSN: 0027-8424
WAGGONER D J ET AL: "The role of copper in neurodegenerative disease.", NEUROBIOLOGY OF DISEASE, vol. 6, no. 4, August 1999 (1999-08-01), pages 221 - 230, XP002339933, ISSN: 0969-9961
CHERNY R A ET AL: "TREATMENT WITH A COPPER-ZINC CHELATOR MARKEDLY AND RAPIDLY INHIBITS BETA-AMYLOID ACCUMULATION IN ALZHEIMER'S DISEASE TRANSGENIC MICE", NEURON, vol. 30, no. 3, June 2001 (2001-06-01), pages 665 - 676, XP001034969
VOSKOBOINIK ILIA ET AL: "The regulation of catalytic activity of the Menkes copper-translocating P-type ATPase: Role of high affinity copper-binding sites", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 30, 27 July 2001 (2001-07-27), pages 28620 - 28627, XP002339934, ISSN: 0021-9258
HOPF C ET AL: "Discovery of new therapeutic targets by integrated protein pathway and chemical proteomic analysis of APP processing", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 2003, 10 November 2003 (2003-11-10), pages 1, XP002292236, ISSN: 0190-5295
WAGGONER D J ET AL: "The role of copper in neurodegenerative disease.", NEUROBIOLOGY OF DISEASE, vol. 6, no. 4, August 1999 (1999-08-01), pages 221 - 230, XP002339933, ISSN: 0969-9961
CHERNY R A ET AL: "TREATMENT WITH A COPPER-ZINC CHELATOR MARKEDLY AND RAPIDLY INHIBITS BETA-AMYLOID ACCUMULATION IN ALZHEIMER'S DISEASE TRANSGENIC MICE", NEURON, vol. 30, no. 3, June 2001 (2001-06-01), pages 665 - 676, XP001034969
VOSKOBOINIK ILIA ET AL: "The regulation of catalytic activity of the Menkes copper-translocating P-type ATPase: Role of high affinity copper-binding sites", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 30, 27 July 2001 (2001-07-27), pages 28620 - 28627, XP002339934, ISSN: 0021-9258
HOPF C ET AL: "Discovery of new therapeutic targets by integrated protein pathway and chemical proteomic analysis of APP processing", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 2003, 10 November 2003 (2003-11-10), pages 1, XP002292236, ISSN: 0190-5295
Download PDF:
Previous Patent: NEW ACYLGLYCEROL ACYLTRANSFERASE-LIKE PROTEINS DC4 AND USES THEREOF
Next Patent: REMOVAL OF PRINT PASTE THICKENER FROM TEXTILE
Next Patent: REMOVAL OF PRINT PASTE THICKENER FROM TEXTILE