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Title:
TRI- OR TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2006/123792
Kind Code:
A1
Abstract:
It is intended to provide quinolone type synthetic antibacterial agents having a potent antibacterial activity against a broad scope of gram-positive and gram-negative bacteria and a high safety and remedies for infections. A compound represented by the following general formula (I), its salt or hydrate thereof: I wherein R1 and R2 represent each hydrogen, etc.; R3 represents C1-6 alkyl, etc.; R4 and R5 independently represent each hydrogen, C1-6 alkyl, etc., provided that R4 and R5 are not hydrogen atoms at the same time, and the above substituents R4 and R5 may be united and form a spiro ring structure structure together with the pyrrolidine ring; R6 and R7 independently represent each hydrogen or C1-6 alkyl; R8 represents a C1-6 haloalkyl group, etc.; X1 represents hydrogen or halogen; and A represents a nitrogen atom or a partial structure represented by the following general formula (II).

Inventors:
TAKAHASHI HISASHI (JP)
INAGAKI HIROAKI (JP)
KOMORIYA SATOSHI (JP)
TAKEMURA MAKOTO (JP)
MIYAUCHI RIE (JP)
Application Number:
PCT/JP2006/310069
Publication Date:
November 23, 2006
Filing Date:
May 19, 2006
Export Citation:
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Assignee:
DAIICHI SEIYAKU CO (JP)
TAKAHASHI HISASHI (JP)
INAGAKI HIROAKI (JP)
KOMORIYA SATOSHI (JP)
TAKEMURA MAKOTO (JP)
MIYAUCHI RIE (JP)
International Classes:
C07D401/04; A61K31/4709; A61K31/5383; A61P31/00; A61P31/04; C07D498/06
Domestic Patent References:
WO1996023775A11996-08-08
Foreign References:
JPH09221424A1997-08-26
EP0787720A11997-08-06
JPS61137885A1986-06-25
EP0787726A11997-08-06
EP0523512A11993-01-20
EP0596126A11994-05-11
EP0470578A11992-02-12
JPH06228138A1994-08-16
EP0259804A21988-03-16
JPH05279364A1993-10-26
JPS63130594A1988-06-02
JPH0725873A1995-01-27
JPS63188626A1988-08-04
JPS63152318A1988-06-24
US4735949A1988-04-05
EP0266576A21988-05-11
EP0700912A11996-03-13
JPH0474167A1992-03-09
EP0265230A11988-04-27
EP0172651A11986-02-26
JPS5872589A1983-04-30
JPS643181A1989-01-06
EP0593766A11994-04-27
EP0341493A21989-11-15
Other References:
FRANZBLAU S.G. ET AL.: "Comparative in vitro activities of 20 fluoroquinolones against Mycobacterium leprae", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 34, no. 2, 1990, pages 229 - 231, XP002941443
See also references of EP 1882689A4
Attorney, Agent or Firm:
The, Patent Corporate Body Aruga Patent Office (3-6 Nihonbashiningyocho 1-chom, Chuo-ku Tokyo 13, JP)
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