Title:
TRIAZOLO-PYRIMIDINE COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/052631
Kind Code:
A1
Abstract:
The present disclosure relates to novel triazolo-pyrimidine compounds targeting adenosine receptors (especially A1 and A2, particularly A2a). The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds as an active ingredient, and use of the compounds in the treatment of adenosine receptor (AR) associated diseases, for example cancer such as NSCLC, RCC, prostate cancer, and breast cancer.
Inventors:
ZENG QINGBEI (CN)
QI CHANGHE (CN)
TSUI HONCHUNG (CN)
YANG ZHENFAN (CN)
ZHANG XIAOLIN (CN)
QI CHANGHE (CN)
TSUI HONCHUNG (CN)
YANG ZHENFAN (CN)
ZHANG XIAOLIN (CN)
Application Number:
PCT/CN2019/105591
Publication Date:
March 19, 2020
Filing Date:
September 12, 2019
Export Citation:
Assignee:
DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/505; A61K31/519; A61P11/06; A61P25/00; A61P25/08; A61P25/24; A61P25/28; A61P35/00; A61P35/02; A61P35/04; C07D519/00
Domestic Patent References:
| WO2019206336A1 | 2019-10-31 | |||
| WO2018166493A1 | 2018-09-20 | |||
| WO2019168847A1 | 2019-09-06 | |||
| WO2018184590A1 | 2018-10-11 |
Foreign References:
| CN109535161A | 2019-03-29 | |||
| CN1596258A | 2005-03-16 | |||
| EP1544200A1 | 2005-06-22 | |||
| EP0976753A1 | 2000-02-02 |
Other References:
See also references of EP 3849983A4
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
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