Title:
TRICYCLIC COMPOUND AS CRTH2 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2018/014867
Kind Code:
A1
Abstract:
Provided are a tricyclic compound as shown in formula (I) as a CRTH2 inhibitor, or a pharmaceutically acceptable salt, a tautomer, a stereoisomer or a solvate thereof, and the use thereof in treating diseases related to CRTH2 receptors.
Inventors:
CHEN BIN (CN)
YAO YUANSHAN (CN)
CHEN YUAN (CN)
LI AO (CN)
XU RAN (CN)
HUANG ZHENSHENG (CN)
TIAN DONGDONG (CN)
LI HONGWEI (CN)
YANG CHENGSHUAI (CN)
LI JIAN (CN)
CHEN SHUHUI (CN)
YAO YUANSHAN (CN)
CHEN YUAN (CN)
LI AO (CN)
XU RAN (CN)
HUANG ZHENSHENG (CN)
TIAN DONGDONG (CN)
LI HONGWEI (CN)
YANG CHENGSHUAI (CN)
LI JIAN (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2017/093850
Publication Date:
January 25, 2018
Filing Date:
July 21, 2017
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
MEDSHINE DISCOVERY INC (CN)
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/4709; A61K31/4985; A61P43/00; C07D487/04
Domestic Patent References:
| WO2002094830A2 | 2002-11-28 | |||
| WO2006052798A2 | 2006-05-18 | |||
| WO2006026273A2 | 2006-03-09 | |||
| WO2005044260A1 | 2005-05-19 | |||
| WO2005123731A2 | 2005-12-29 |
Foreign References:
| CN101189011A | 2008-05-28 |
Other References:
BEALTLIEU, C. ET AL.: "Identification of Prostaglandin D2 Receptor Antagonists Based on a Tetrahydropyridoindole Scaffold", BIOORG. MED. CHEM. LETT., vol. 18, 10 March 2008 (2008-03-10), pages 2696 - 2700, XP022606374, DOI: doi:10.1016/j.bmcl.2008.03.015
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: doi:10.1002/jps.2600660104
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT, WILLIAMS & WILKINS
See also references of EP 3489235A4
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: doi:10.1002/jps.2600660104
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT, WILLIAMS & WILKINS
See also references of EP 3489235A4
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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