[0001] This application claims priority from US Provisional Application 61/642,101, filed May 3, 2012, incorporated herein by reference in its entirety.

BACKGROUND

[0002] The present invention relates to a tube for an intravascular medical device, and in particular to a sensor guide wire comprising such a tube.

[0003] Today, there is an increased need for invasive measurements of physiological variables. For example, when investigating cardiovascular diseases, it is strongly desired to obtain local measurements of blood pressure, flow and temperature in order to evaluate the condition of the subject under measurement. Therefore, methods and devices have been developed for disposing a miniature sensor inside the body of an individual at a location where the measurements should be performed, and for communicating with the miniature sensor in order to provide the physician or medical technician with critical information as to the status of a patient's condition. Typically, the miniature sensor is arranged at a distal end of a guide wire, which is generally known in the art, and used for example in connection with the treatment of coronary disease.

[0004] The distal end of the guide wire is inserted into the body of a patient, for example into an opening of the femoral artery, and placed at a desired location. Once the guide wire is placed by the physician into the appropriate location, the miniature sensor can measure the blood pressure and/or flow. The measurement of blood pressure is a way to diagnose e.g. the significance of a stenosis. For evident reasons, the dimensions of the sensor and the guide wire are fairly small; the guide wire typically has a diameter of 0.35 mm. The sensor element may, for example, be embodied by an elongated, essentially rectangular chip with a pressure sensitive member in the form of a membrane provided thereon.

[0005] In order to power the sensor and to communicate signals representing the measured physiological variable to a control unit acting as an interface device disposed outside the body, one or more microcables for transmitting the signals are connected to the sensor, and are routed along the guide wire to be passed out from the vessel to an external control unit via a connector assembly. Most commonly, extremely thin electrical cables are provided inside the guide wire, which itself is provided in the form of a tube (having an outer diameter of e.g. 0.35 mm), oftentimes made of stainless steel. In order to increase the bending strength and maneuverability of the tubular guide wire, a core wire is positioned inside the tube. The mentioned electrical leads are positioned in the space between the inner lumen wall of the tube and the core wire. Furthermore, the sensor chip is often arranged in a short tube, also referred to as a jacket or a sleeve. The jacket is hollow and accommodates, besides the sensor chip, a portion of a core wire and often at least one microcable. A first coil may be attached to the distal end of the jacket, and optionally a second coil may be attached to the proximal end of the jacket. The first and second coils may be attached to the respective end of the jacket, e.g. by gluing, welding or alternatively soldering. One purpose of the first coil is to enable the steering of the sensor guide wire through winding blood vessels. To help the user easily guide the wire through such tortuous vessel systems, the distal coil is often

radioopaque, such that it is visible on an angiogram.

[0006] A large flexibility of the sensor guide wire can be advantageous in that it allows the sensor guide wire to be introduced into small and tortuous vessels. It should, however, also be recognized that if the core wire is too flexible, it would be difficult to push the sensor guide forward into the vessels, i.e. the sensor guide wire must possess a certain "pushability" and a certain "torquability." Additionally, the sensor guide must be able to withstand the mechanical stress exerted on the core wire especially in sharp vessel bends.

[0007] Besides being flexible enough, it can be also important that the sensor guide wire tip responds when steering the sensor guide wire through the tortuous vessels, i.e. the sensor guide wire tip should also have sufficient "steering response." "Steering response" is a measure of the behavior of a sensor guide wire when the sensor guide wire tip is subjected to a non-linear pathway and rotated. The "steering response" of a sensor guide wire tip is a general property of the distal tip components.

[0008] Several different designs of sensor guide wires are known in the prior art, and examples of such sensor guide wires are disclosed in US 6167763 Bl, which describes the cantilevered mounting of the sensor element, US RE39863 El, which discloses the sensor element and US 6248083 Bl, showing the complete sensor guide wire assembly, which all are assigned to the assignee of the present application, and which are hereby all incorporated by reference for the devices and methods described therein.

[0009] A presently used sensor wire (the Pressure Wire™) has proven to fulfill the high requirements regarding torque response. However, the inventors of the present invention have identified a need for a sensor guide wire with further improved torsional rigidity, which thus has a higher polar moment of inertia. There is further a need for a sensor guide wire for which torque response and bending stiffness are optimized to suit the specific needs of each portion of the sensor guide wire.

[0010] It is generally known to provide an intravascular medical device with a so-called hypotube to achieve specific properties of the medical device. For example in WO

2009/020961 Al, a medical device for intravascular use comprising a hypotube is disclosed. The object is to provide a medical device which is configured to have a preferential bending direction, which in particular is achieved by providing slots having different widths.

[0011] Furthermore, EP 1545680 Bl also discloses a medical device for navigating through the anatomy. The medical device comprises a hypotube provided with slots, wherein the slots may be of unequal size.

[0012] In US 2010/0145308 Al, a medical device including an elongated tubing provided with slots in the wall is disclosed. The slots in a group may be unequal in size.

[0013] However, these known hypotubes do not possess the required torque response. A further drawback with known hypotubes is that twisting of the hypotube might lead to permanent deformation.

SUMMARY

[0014] An object of the present invention is to achieve a sensor guide wire with improved torque response.

[0015] A further object of the present invention is to provide a sensor guide wire with improved torque response, while keeping the low bending stiffness, such that the sensor guide wire allows for the same bending radius as the current sensor guide wire.

[0016] Still another object of the present invention is to provide a sensor guide wire for which torsion and bending stiffness may be tailored according to specific needs.

[0017] The above mentioned objects may be achieved by providing the sensor guide wire with a tube making up essentially the entire length of the sensor guide wire, from the proximal end to a distal portion of the sensor guide wire. [0018] According to one aspect of the present invention, the tube may be implemented in any intravascular medical device, such as a sensor guide wire, a guide wire, a catheter or similar device.

[0019] In accordance with one embodiment of the present invention, the tube may have a longitudinal extension along a longitudinal axis A, and the tube may comprise a tube wall having a specified thickness. The tube wall may be provided with a plurality of through- going slots, wherein each slot has an essentially elongated shape along a main extension B extending along the circumference of the tube. Each slot has a width W and a length L along the main extension B, and wherein at least two slots are provided in a plane perpendicular to the longitudinal axis A, and the main extension B of the at least two slots are in said plane. A predetermined number of planes with slots may be provided along the tube, and the lengths L of the slots in the same perpendicular plane are essentially the same. The lengths L of the slots in different planes vary along the longitudinal extension of the tube according to a predefined pattern.

[0020] The tube according to an embodiment of the present invention can be flexible enough when it comes to bending while keeping much of its torsional rigidity.

[0021] By implementing the suggested tube in a sensor guide wire, a higher torsional rigidity can be achieved. The tube can be provided for a sensor guide wire having a higher polar moment of inertia, while keeping the low bending stiffness, such that the sensor guide wire allows for the same bending radius as the presently used wires.

[0022] Thus, according to another aspect, the present invention may relate to a sensor guide wire for intravascular measurements of at least one physiological or other variable in a living body.

[0023] The sensor guide wire according to one embodiment of the present invention may comprise a tube, the sensor guide wire having a proximal region, a distal sensor region and a tip region. The sensor guide wire may comprise a sensor element arranged in the sensor region, the sensor element comprising a sensor portion, for measuring said variable and to generate a sensor signal in response to said variable. The tube may extend at least partly along said proximal region. [0024] According to yet another aspect of the present invention, the tube may further extend at least partly along the distal sensor region of the sensor guide wire, wherein the tube is adapted to enclose at least a part of the sensor element, and being provided with at least a first sensor opening in the distal sensor region.

[0025] The predetermined pattern of the tube may allow an optimized ratio between torsional and bending rigidity.

[0026] According to a further aspect, the present invention may relate to a sensor guide wire comprising a tube, which sensor guide wire is "core-wire free," i.e., no core wire is arranged inside and along the tube.

[0027] It is to be understood that both the foregoing general description and the following detailed descriptions are exemplary and explanatory only, and are not restrictive of the invention as claimed.

BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The features, aspects and advantages of the present invention will become apparent from the following description, appended claims, and the accompanying exemplary embodiments shown in the drawings, which are briefly described below.

[0029] Figure 1 shows a tube for an intravascular medical device according to one embodiment of the present invention.

[0030] Figure 2 shows a detail C of the tube shown in Figure 1.

[0031] Figure 3 shows a cross-section III-III of the tube shown in Figure 1.

[0032] Figure 4 shows the tube comprising a distal section and a proximal section according to one embodiment of the present invention.

[0033] Figure 5 a shows a diagram which illustrates how the slot angle varies in the distal section and the proximal section, according to one embodiment of the present invention.

[0034] Figure 5b shows schematically that the lengths of the slots decreases continuously along the proximal section and that the lengths of the slots are equal along the distal section, according to one embodiment of the present invention. [0035] Figure 6 schematically shows a distal portion of a sensor guide wire, the sensor guide wire comprising a tube and a jacket which is arranged in a distal sensor region, according to one embodiment of the present invention.

[0036] Figure 7 schematically shows a distal portion of a sensor guide wire, the sensor guide wire comprising a tube which extends at least partly along the proximal region and further along the distal sensor region, according to one embodiment of the present invention.

[0037] Figure 8 schematically shows a sensor guide wire according to another embodiment of the present invention.

[0038] Figure 9 schematically shows a first close up view of the sensor guide wire of Figure 8.

[0039] Figure 10 schematically shows a second close up view of the sensor guide wire of Figure 8.

[0040] Figure 11 shows a detail D of the tube shown in Figure 10.

[0041] Figure 12 shows a detail E of the tube shown in Figure 10.

[0042] Figure 13 shows a cross-section XIII-XIII of the tube shown in Figure 10.

[0043] Figure 14 shows a cross-section XIV-XIV of the tube shown in Figure 10.

[0044] Figure 15 shows a cross-section XV -XV of the tube shown in Figure 10.

[0045] Figure 16 shows a cross-section XVI-XVI of the tube shown in Figure 10.

[0046] Figure 17 schematically shows a sensor guide wire according to another

embodiment of the present invention.

[0047] Figure 18 schematically shows a first close up view of the sensor guide wire of Figure 17.

[0048] Figure 19 schematically shows a second close up view of the sensor guide wire of Figure 17.

[0049] Figure 20 shows a detail I of the tube shown in Figure 19. [0050] Figure 21 shows a cross-section XXI-XXI of the tube shown in Figure 19.

[0051] Figure 22 shows a detail F of the tube shown in Figure 19.

[0052] Figure 23 shows a cross-section XXIII-XXIII of the tube shown in Figure 19.

[0053] Figure 24 shows a cross-section XXIV-XXIV of the tube shown in Figure 19.

[0054] Figure 25 shows a detail G of the tube shown in Figure 19.

[0055] Figure 26 shows a detail H of the tube shown in Figure 19.

[0056] Figure 27 shows a cross-section XXVII-XXVII of the tube shown in Figure 19.

[0057] Figure 28 shows a section of tube according to another embodiment of the present invention.

[0058] Figure 29 shows a cross-section XXIX-XXIX of the tube section shown in Figure 29.

DETAILED DESCRIPTION

[0059] With reference to Figure 1 , a tube 1 , for an intravascular medical device, according to one embodiment of the present invention, is shown. The tube 1 has a longitudinal extension along a longitudinal axis A, and the tube 1 comprises a tube wall 2 having a specified thickness t (see Figure 3). The tube wall 2 is provided with a plurality of through- going slots 3. Preferably, the specified thickness t of the tube wall 2 is approximately 0.05 mm. However, the thickness may be between 0.05 - 2.0 mm. The tube 1 may be provided with a sensor opening 7, as illustrated in Figure 1. This may be the case when the tube 1 is implemented in a sensor guide wire. However, when the tube 1 is being implemented in, for example, a guide wire or a catheter, the sensor opening 7 may be omitted. In addition, in other embodiments implementing a sensor guide wire, the tube 1 may be provided with additional openings allowing access to the sensor.

[0060] Figure 2 shows a detail C of the tube 1 shown in Figure 1. As illustrated in Figure 2, each slot 3 has an essentially elongated shape along a main extension B extending along the circumference of the tube 1. Each slot 3 has a width W and a length L along the main extension B. At least two slots 3 are provided in a plane P perpendicular to the longitudinal axis A, the main extension B of the at least two slots 3 being in the plane P. A predetermined number of planes P with slots 3 are provided along the tube 1. Preferably, the width W of a slot 3 is approximately 0.05 mm. However, the width W of a slot 3 may be between 0.05 - 2.0 mm.

[0061] In Figure 3, a cross-section III-III of the tube 1 in Figure 1 is illustrated. The cross- section III-III illustrates one of the planes P perpendicular to the longitudinal axis A. Three slots 3 are provided in the plane P; however two slots could be used. The slots 3 in the same perpendicular plane P are separated by a slot separation part 4. The lengths L of the slots 3 in the same perpendicular plane P are essentially the same.

[0062] As further illustrated in Figure 3, the slots 3 in the same perpendicular plane P are equally distributed around the circumference of the tube 1. The length L of a slot 3 may be defined by a slot angle a, the slot angle being the center angle of the perpendicular plane P. The slot angle is 0° < a < 120°.

[0063] In the embodiment shown in Figure 3, three equally distributed slots 3 are provided in each plane P. Furthermore, as illustrated in Figure 2, the slots 3 in a perpendicular plane P are displaced in relation to the slots 3 in an adjacent perpendicular plane P. Preferably, the slots 3 in a perpendicular plane P are displaced approximately 60° with respect to each adjacent perpendicular plane P. However, the degree of displacement may be any angle between 0° and 120°. In case of 0° or 120°, there is no displacement between the slots 3 in the adjacent planes P.

[0064] According to another embodiment, four slots 3 may be provided in each

perpendicular plane P. In this case, preferably, the slots 3 in a perpendicular plane P are displaced approximately 45° with respect to each adjacent perpendicular plane P. In case of four slots 3 in each plane P, the degree of displacement may be any angle between 0° and 90°. As mentioned above, in case of 0° or 90°, there is no displacement between the slots 3 in the adjacent planes P. Preferably, the degree of displacement is the same between all

perpendicular planes P. However, the degree of displacement with respect to an adjacent perpendicular plane P may vary along the tube 1. Preferably, the number of slots 3 provided in each plane P is between 3 and 10.

[0065] In the embodiment illustrated in Figure 4, which shows a portion of a tube 1, the lengths L of the slots 3 in different planes P vary along the longitudinal extension of the tube 1 , according to a predefined pattern. However, in the drawing, the varying lengths L of the slots 3 can not be seen, this is instead shown in Figure 5b. Figure 5b illustrates schematically that the lengths L of the slots 3 in different planes P varies along the longitudinal extension of the tube 1.

[0066] According to the predefined pattern shown in Figure 4, the lengths L of the slots 3 decreases in a proximal direction of the tube 1. The lengths L of the slots 3 may decrease continuously. Furthermore, according to the predefined pattern, the lengths L of the slots 3 are equal in a distal section 5 of the tube 1. As seen in Figure 4, in the portion of the tube 1 which is proximal to the proximal section 6, no slots are provided in the tube wall 2.

However, according to another embodiment, there may be slots provided proximal to the proximal section 6. Preferably, the distal section 5 and the proximal section 6 are arranged adjacent to each other. However, according to another embodiment, there may be an intermediate section (not shown) without slots arranged between the distal section 5 and the proximal section 6. The tube wall 2 may be provided with a sensor opening 7 in a distal portion of the tube 1.

[0067] In one embodiment, the length LA, along the longitudinal axis A, of the distal section 5 is approximately 150 mm. The length LA, along the longitudinal axis A, of the proximal section 6 may be approximately 200 mm. However, the length LA of the distal section 5 may be between 0-3000 mm, and the length of the proximal section 6 may be between 0-3000 mm.

[0068] According to one embodiment, the tube 1 is adapted to extend at least partly along the length of a guide wire, a sensor guide wire, or a catheter.

[0069] In one embodiment, the tube 1 is provided with a coating covering all, or parts of, the slots. The coating may be made from polyimide, polyurethane, polypropylene, or thermoplastic elastomers, such as a styrene-diene triblock copolymers, polyolefm blend, block copolyurethane, block copoly(ether-ester) and block copoly(ether-amide). In some embodiments, providing the tube 1 with a coating completely covering slots 3 is

advantageous in that it prevents ambient fluid, e.g. blood, from entering into the interior of the tube 1. In other embodiments, the coating may provide either a hydrophilic or

hydrophobic outer surface, to optimize the frictional forces between the outer surface of the tube 1 and e.g. the vessel wall or a catheter. This can be accomplished by choosing a material with proper hydrophilic/hydrophobic properties or by surface modification and/or treatment of abovementioned polymeric coating materials.

[0070] As illustrated in Figures 2 and 4, adjacent perpendicular planes P are separated by a predetermined separation distance d, being approximately 0.1 mm (see also Figure 2).

However, the distance d may be between 0.05 - 4.0 mm. According to one embodiment, the predetermined number of perpendicular planes P is between 1000 - 10000, preferably the predetermined number of planes P is in the interval 1000-5000, and more preferably the predetermined number of planes P is approximately 3500.

[0071] According to one embodiment, as illustrated by the diagram shown in Figure 5a, the lengths L of the slots 3 decreases continuously. The slot angle a decreases from

approximately 40° to approximately 0°, i.e. no slots, in a proximal section 6 of the tube 1, and the slot angle a is approximately 40° in the distal section 5 of the tube 1.

[0072] In one embodiment, the tube 1 has an inner diameter of approximately 0.25 mm, and an outer diameter of approximately 0.35 mm.

[0073] In Figure 5b the proximal section 6 and the distal section 5 are schematically shown. In Figure 5b, some slots 3 have been omitted for sake of simplicity. As mentioned above, Figure 5b schematically illustrates that the lengths L of the slots 3 decreases continuously along the proximal section 6 and the lengths L of the slots 3 are equal, or essentially equal, along the distal section 5, according to one embodiment of the present invention.

[0074] Figure 6 illustrates a sensor guide wire 8 for intravascular measurements of at least one physiological or other variable in a living body, comprising a tube 1 as described herein. In the embodiment shown in Figure 6, the sensor guide wire 8 has a proximal region 9, a distal sensor region 10 and a tip region 11. The sensor guide wire 8 comprises a sensor element 12 arranged in the sensor region 10, and comprising a sensor portion 13, for measuring the variable and to generate a sensor signal in response to the variable. The tube 1 extends at least partly along the proximal region 9 of the sensor guide wire 8. The sensor guide wire 8 comprising a tube 1 as described herein achieves all requirements set up for the sensor guide wire 8, i.e. the sensor guide wire 8 provides an optimized ratio between torsional and bending rigidity. [0075] As illustrated in Figure 6, the tube 1 extends at least partly along the proximal region 9. Furthermore, the sensor guide wire 8 is provided with a jacket 15 enclosing at least a portion of the sensor element 12. The jacket 15 extends along the distal sensor region 10. The jacket 15 is further provided with at least a first sensor opening 7 in the distal sensor region 10. The jacket 15 may be provided with additional openings allowing access to the sensor element 12. Preferably, the proximal end 16 of the jacket 15 is attached to a distal end 17 of the tube 1. In another embodiment, the tube 1 may extend along the proximal region 9 and further in at least parts of the distal sensor region 10.

[0076] In the embodiment shown in Figure 7, the sensor guide wire 8 has a proximal region 9, a distal sensor region 10 and a tip region 11. The sensor guide wire 8 comprises a sensor element 12 arranged in the sensor region 10, and comprising a sensor portion 13, for measuring the variable and to generate a sensor signal in response to the variable. The tube 1 extends at least partly along the proximal region 9. The tube 1 further extends along the distal sensor region 10, and is adapted to enclose at least a part of the sensor element 12. The tube 1 is provided with at least a first sensor opening 7 in the distal sensor region 10.

[0077] Thus, according to one embodiment, as illustrated in Figure 7, the tube 1 runs along the proximal region 9 and the entire distal sensor region 10, such that the sensor region 10 is an integrated part of the tube 1.

[0078] In one embodiment, no core wire is arranged to extend along the proximal region 9. In another embodiment, no core wire is arranged to extend along the distal sensor region 10. In yet another embodiment, no core wire is arranged to extend along the proximal region 9 and the distal sensor region 10. Accordingly, the sensor guide wire 8 may be core wire free, wherein the tube 1 provides the same properties as a core wire. A security string (not shown) may extend from a proximal end (not shown) to a distal end 14, or at least to the tip region 11, of the sensor guide wire 8. The security string may be a flexible wire running inside the tube 1.

[0079] Preferably, the security string is embodied by a relatively thin flexible wire. The security string may be attached, at its distal end to e.g. a distal part of the sensor guide wire 8. Preferably, the security string is attached essentially at the distal end 14, or to a tip core wire (not shown) running along the tip region 11 of the sensor guide wire 8. The reason for arranging such a security string is to ensure all parts are held together by the string. However, in another embodiment, the sensor guide wire 8 may be provided with a core wire running inside and along the tube 1.

[0080] According to the embodiments shown in Figures 6-7, the distal section 5 and the proximal section 6 of the tube 1 are arranged in the proximal region 9 of the sensor guide wire 8.

[0081] Figures 8-10 illustrate a sensor guide wire 108 for an intravascular measurement of at least one physiological or other variable in a living body, comprising a tube 101. The sensor guide wire 108 has a proximal region 109, a distal sensor region 110 and a tip region 111. The sensor guide wire 108 comprises a sensor element arranged in the sensor region 110, and comprising a sensor portion for measuring the variable and to generate a sensor signal in response to the variable. The tube 101 extends at along the proximal region 109, the entire distal sensor region 110, and the tip region 111 of the sensor guide wire 108. Thus, according to the embodiment in Figures 8-10, the tube 101 runs along the proximal region 109, the entire distal sensor region 110, and the tip region 111 such that the sensor region 110 and the tip region 111 are an integrated part of the tube 101.

[0082] The distal sensor region 110 is further provided with at least a first sensor opening

107. The distal sensor region 110 may be provided with additional openings 107 allowing access to the sensor element 12. As seen in Figures 10 and 15, there may be three openings at two different locations along the longitudinal axis of the distal sensor region 110.

[0083] In one embodiment, no core wire is arranged to extend along the proximal region

109. In another embodiment, no core wire is arranged to extend along the distal sensor region

110. In yet another embodiment, no core wire is arranged to extend along the proximal region 109 and the distal sensor region 110. Accordingly, the sensor guide wire 108 may be core wire free, wherein the tube 101 provides the same properties as a core wire. A security string (not shown) may extend from a proximal end (not shown) to a distal end, or at least to the tip region 111, of the sensor guide wire 108. The security string may be a flexible wire running inside the tube 101.

[0084] Preferably, the security string is embodied by a relatively thin flexible wire. The security string may be attached, at its distal end to e.g. a distal part of the sensor guide wire

108. Preferably, the security string is attached essentially at the distal end of the senor guide wire 108. However, in another embodiment, the sensor guide wire 108 may be provided with a core wire running inside and along the tube 101.

[0085] With reference to Figures 9, 10, and 13, the tube 101 has a longitudinal extension along a longitudinal axis A', and the tube 101 comprises a tube wall 102 having a specified thickness t'. Preferably, the specified thickness t' of the tube wall 102 is approximately 0.05 mm. However, the thickness may be between 0.02 - 2.0 mm. The tube 101 may be provided with the sensor opening 107, as illustrated in Figures 8-10. This may be the case when the tube 101 is implemented in a sensor guide wire. However, when the tube 101 is being implemented in, for example a guide wire or a catheter, the sensor opening 107 may be omitted. In addition, the tube 101 is provided with additional openings 107 allowing access to the sensor, but these additional openings 107 may be omitted.

[0086] In Figure 15, a cross-section XV-XV of the tube 101 in Figure 10 illustrates one of the planes perpendicular to the longitudinal axis in the distal sensor region 110 with openings 107. Three openings 107 are provided in the plane. The openings 107 in the same

perpendicular plane P' are separated by a slot separation part 120. The lengths of the openings 107 in the same perpendicular plane are essentially the same. The openings 107 in the same perpendicular plane P' are equally distributed around the circumference of the tube 101. The length of an opening 107 may be defined by a slot angle α'", the slot angle being the center angle of the perpendicular plane. The slot angle is 0° < α'" < 120°, preferably about 50°. In the embodiment shown in Figure 15, three equally distributed openings 107 are provided in each plane. The length L ₀ of each opening 107 may be any suitable length, such as for example between 0.25 to 2 mm, preferably 0.7 mm. Also the distance d ₀ between adjacent openings in the longitudinal axis may be any suitable distance, such as for example 0.1 to 1 mm, preferably 0.4 mm.

[0087] Figure 11 shows a detail D of the tube 101 shown in Figure 10. As illustrated in Figure 11, each slot 103 has an essentially elongated shape along a main extension B' extending along the circumference of the tube 101. Each slot 103 has a width W and a length L' along the main extension B'. At least two slots 103 are provided in a plane P'

perpendicular to the longitudinal axis A', the main extension B' of the at least two slots 103 being in the plane P'. A predetermined number of planes P' with slots 103 are provided along the tube 101. Preferably, the width W of a slot 103 is approximately 0.02 mm. However, the width W of a slot 103 may be between 0.01 - 2.0 mm. [0088] In Figure 13, a cross-section XIII-XIII of the tube 101 in Figure 10 is illustrated at the proximal region 109 with no slots. In Figure 14, the cross-section XIV-XIV illustrates one of the planes P' perpendicular to the longitudinal axis A' in the proximal region 109 with slots. Three slots 103 are provided in the plane P'; however, two slots may be used instead. The slots 103 in the same perpendicular plane P are separated by a slot separation part 104. The lengths L' of the slots 103 in the same perpendicular plane P' are essentially the same. As further illustrated in Figure 14, the slots 103 in the same perpendicular plane P' are equally distributed around the circumference of the tube 101. The length L' of a slot 103 may be defined by a slot angle α', the slot angle being the center angle of the perpendicular plane P'. The slot angle is 0° < a' < 160°, preferably about 95°.

[0089] In the embodiment shown in Figure 14, three equally distributed slots 103 are provided in each plane P'; however, two slots could be used instead. Furthermore, as illustrated in Figure 11, the slots 103 in a perpendicular plane P' are displaced in relation to the slots 103 in an adjacent perpendicular plane P'. Preferably, the slots 103 in a

perpendicular plane P' are displaced approximately 60° with respect to each adjacent perpendicular plane P'. However, the degree of displacement may be any angle between 0° and 120°.

[0090] As illustrated in Figure 11, adjacent perpendicular planes P' are separated by a predetermined separation distance d', being approximately 0.04 mm. However, the distance d' may be between 0.01 - 4.0 mm. According to one embodiment, the predetermined number of perpendicular planes P is between 1000 - 10000, preferably the predetermined number of planes P is in the interval 1000-5000, and more preferably the predetermined number of planes P is approximately 3500.

[0091] The tube 101 may be provided with a plurality of slots. Figure 12 shows a detail E of the tube 101 shown in Figure 10. As illustrated in Figure 12, each slot 103' has an essentially elongated shape along the main extension B' extending along the circumference of the tube 101. Each slot 103' has a width W" and a length L" along the main extension B'. At least two slots 103' are provided in a plane P' perpendicular to the longitudinal axis A', the main extension B' of the at least two slots 103' being in the plane P'. A predetermined number of planes P' with slots 103' are provided along the tube 101. Preferably, the width W" of a slot 103' is approximately 0.02 mm. However, the width W of a slot 103' may be between 0.01 - 2.0 mm. [0092] In Figure 16, a cross-section XVI-XVI of the tube 101 in Figure 10 illustrates one of the planes P' perpendicular to the longitudinal axis A' in the tip region 111 with slots. Three slots 103' are provided in the plane P'; however two slots could be used instead. The slots 103' in the same perpendicular plane P' are separated by a slot separation part 104'. The lengths L" of the slots 103 in the same perpendicular plane P' are essentially the same. As further illustrated in Figure 16, the slots 103' in the same perpendicular plane P' are equally distributed around the circumference of the tube 101. The length L" of a slot 103 ' may be defined by a slot angle a", the slot angle being the center angle of the perpendicular plane P'. The slot angle is 0° < a' < 160°, preferably about 105°. Furthermore, as illustrated in Figure 12, the slots 103' in a perpendicular plane P' are displaced in relation to the slots 103' in an adjacent perpendicular plane P'. The degree of displacement may be any angle between 0° and 120°.

[0093] As illustrated in Figure 12, adjacent perpendicular planes P' are separated by a predetermined separation distance d", being approximately 0.02 mm. However, the distance d' ' may be between 0.01 - 4.0 mm. According to one embodiment, the predetermined number of perpendicular planes P is between 1000 - 10000, preferably the predetermined number of planes P is in the interval 1000-5000, and more preferably the predetermined number of planes P is approximately 3500.

[0094] In the embodiment of Figures 8-10, the tube 101 may optionally be provided with a coating covering all, or parts of, the slots 103 and 103'. The coating may be made from polyimide, polyurethane, polypropylene, or thermoplastic elastomers, such as a styrene-diene triblock copolymers, polyolefm blend, block copolyurethane, block copoly(ether-ester) and block copoly(ether-amide). In some embodiments, providing the tube 101 with a coating completely covering slots 103 and 103' is advantageous in that it prevents ambient fluid, e.g. blood, from entering into the interior of the tube 101. In other embodiments, the coating may provide either a hydrophilic or hydrophobic outer surface, to optimize the frictional forces between the outer surface of the tube 101 and e.g. the vessel wall or a catheter. This can be accomplished by choosing a material with proper hydrophilic/hydrophobic properties or by surface modification and/or treatment of abovementioned polymeric coating materials.

[0095] Figures 17-19 illustrate a sensor guide wire 208 for an intravascular measurement of at least one physiological or other variable in a living body, comprising a tube 201. The embodiment of Figures 17-19 is a variation of the embodiment in Figures 8-10 with some differences, for example, the angle of displacement for the slots in the proximal region of Fig. 22 is 10° instead of 60° (as shown in the proximal region of Figure 11). In the embodiment shown in Figures 17-19, the sensor guide wire 208 has a proximal region 209, a distal sensor region 210 and a tip region 211. The sensor guide wire 208 comprises a sensor element arranged in the sensor region 210, and comprising a sensor portion for measuring the variable and to generate a sensor signal in response to the variable. The tube 201 extends at along the proximal region 209, the entire distal sensor region 210, and the tip region 211 of the sensor guide wire 208. Thus, according to the embodiment in Figures 17-19 and 23, the tube 201 runs along the proximal region 209, the entire distal sensor region 210, and the tip region 211 such that the sensor region 210 and the tip region 211 are an integrated part of the tube 201.

[0096] The distal sensor region 210 is further provided with at least a first sensor opening

207. The distal sensor region 210 may be provided with additional openings 207 allowing access to the sensor element. As seen in Figures 17-19, there may be three openings at two different locations along the longitudinal axis of the distal sensor region 210.

[0097] In one embodiment, no core wire is arranged to extend along the proximal region

209. In another embodiment, no core wire is arranged to extend along the distal sensor region

210. In yet another embodiment, no core wire is arranged to extend along the proximal region 209 and the distal sensor region 210. Accordingly, the sensor guide wire 208 may be core wire free, wherein the tube 201 provides the same properties as a core wire. A security string (not shown) may extend from a proximal end (not shown) to a distal end, or at least to the tip region 211, of the sensor guide wire 208. The security string may be a flexible wire running inside the tube 201.

[0098] Preferably, the security string is embodied by a relatively thin flexible wire. The security string may be attached, at its distal end to e.g. a distal part of the sensor guide wire

208. Preferably, the security string is attached essentially at the distal end of the senor guide wire 208. However, in another embodiment, the sensor guide wire 208 may be provided with a core wire running inside and along the tube 201.

[0099] With reference to Figures 18, 19, and 21, the tube 201 has a longitudinal extension along a longitudinal axis A _ls and the tube 201 comprises a tube wall 202 having a specified thickness t . Preferably, the specified thickness t of the tube wall 202 is approximately 0.05 mm. However, the thickness may be between 0.02 - 2.0 mm. The tube 201 may be provided with the sensor opening 207, as illustrated in Figures 17-19. This may be the case when the tube 201 is implemented in a sensor guide wire. However, when the tube 201 is being implemented in, for example a guide wire or a catheter, the sensor opening 207 may be omitted. In addition, the tube 201 is provided with additional openings 207 allowing access to the sensor, but these additional openings 207 may be omitted.

[0100] In Figure 23, a cross-section XXIII-XXIII of the tube 201 in Figure 19 illustrates one of the planes perpendicular to the longitudinal axis in the distal sensor region 210 with openings 207. Three openings 207 are provided in the plane Pi. The openings 207 in the same perpendicular plane Pi are separated by a slot separation part 220. The lengths of the openings 207 in the same perpendicular plane are essentially the same. As further illustrated in Figure 23, the openings 207 in the same perpendicular plane Pi are equally distributed around the circumference of the tube 201. The length of an opening 207 may be defined by a slot angle ai, the slot angle being the center angle of the perpendicular plane. The slot angle is 0° < ai < 120°, preferably about 50°. In the embodiment shown in Figure 23, three equally distributed openings 207 are provided in each plane. The length Li of each opening 207 may be any suitable length, such as for example between 0.25 to 2 mm, preferably 0.7 mm. Also the distance di between adjacent openings in the longitudinal axis may be any suitable distance, such as for example 0.1 to 1 mm, preferably 0.4 mm.

[0101] The tube 201 may be provided with a plurality of slots. Figure 22 shows a detail F of the tube 201 shown in Figure 19. As illustrated in Figure 22, each slot 203 has an essentially elongated shape along a main extension Bi extending along the circumference of the tube 201. Each slot 203 has a width Wi and a length Li along the main extension Bi. At least two slots 203 are provided in a plane Pi perpendicular to the longitudinal axis A _ls the main extension Bi of the at least two slots 203 being in the plane Pi. A predetermined number of planes Pi with slots 203 are provided along the tube 201. Preferably, the width Wi of a slot 203 is approximately 0.04 mm. However, the width Wi of a slot 203 may be between 0.01 - 2.0 mm.

[0102] In Figure 21, a cross-section XXI-XXI of the tube 201 in Figure 19 is illustrated at the proximal region 209 with no slots. In Figure 24, the cross-section XXIV-XXIV illustrates one of the planes Pi perpendicular to the longitudinal axis Ai in the proximal region 209 with slots. Three slots 203 are provided in the plane Pi; however two slot would be used instead. The slots 203 in the same perpendicular plane Pi are separated by a slot separation part 204. The lengths of the slots 203 in the same perpendicular plane Pi are essentially the same. As further illustrated in Figure 24, the slots 203 in the same perpendicular plane Pi are equally distributed around the circumference of the tube 201. The length of a slot 203 may be defined by a slot angle a ₂ , the slot angle being the center angle of the perpendicular plane Pi. The slot angle is 0° < a ₂ < 160°, preferably about 95°.

[0103] In Figure 24, three equally distributed slots 203 are provided in each plane Pi.

Furthermore, as illustrated in Figure 22, the slots 203 in a perpendicular plane Pi are displaced in relation to the slots 203 in an adjacent perpendicular plane Pi. Preferably, the slots 203 in a perpendicular plane Pi are displaced approximately 10° with respect to each adjacent perpendicular plane Pi. However, the degree of displacement may be any angle between 0° and 120°.

[0104] As illustrated in Figures 22 and 25, adjacent perpendicular planes Pi are separated by a predetermined separation distance. For example, in the segment Si of the proximal region 209, the separation distance d ₂ between adjacent perpendicular planes may be a constant value, such as a value between about 0.10 mm and about 4.0 mm, preferable about 0.18 mm or 0.14 mm. In segment S ₂ of the proximal region 209, the separation distance between adjacent perpendicular planes decrease in a linear fashion from the constant value d ₂ down to a lower value d ₃ . The separation distance d ₃ may be a value between about 0.10 mm and about 0.01 mm, preferably about 0.025 mm. The lengths of segments Si and S ₂ may be any sub-portion of the proximal region 209. For example, the combined length of segments Si and S ₂ may be between about 100 mm to about 1000 mm, preferably 290 mm, The ratio of the length of S ₂ relative to Si may be any suitable ratio, such as, for example, 0, 0.1 , 0.2, 0.3, 0.4, 0.5, 0.6, 0.7 0.8, 0.9, or 1 or any value therebetween. Alternatively, the ratio of the length of Si relative to S ₂ may be any suitable ratio, such as, for example, 0, 0.1 , 0.2, 0.3, 0.4, 0.5, 0.6, 0.7 0.8, 0.9, or 1 or any value therebetween. According to another embodiment, as seen in Figure 25, a number of adjacent perpendicular planes at the end portion of the proximal region 209 nearest the distal sensor region 210 may be at the constant distance d ₃ from each other. For example, one, two, three, four, twenty, fifty, or more or any integer in- between of the adjacent perpendicular planes at the end portion of the proximal region 209 nearest the distal sensor region 210 may have a separation distance from their adjacent perpendicular planes at the lower value d ₃ . According to one embodiment, the predetermined number of perpendicular planes Pi is between 1000 - 10000, preferably the predetermined number of planes Pi is in the interval 1000-5000, and more preferably the predetermined number of planes Pi is approximately 3500.

[0105] Figure 26 shows a detail H of the tube 201 shown in Figure 19. As illustrated in Figure 26, each slot 203 ' has an essentially elongated shape along the main extension Bi extending along the circumference of the tube 201. Each slot 203 ' has a width W ₂ and a length L ₂ along the main extension Bi. At least two slots 203 ' are provided in a plane Pi perpendicular to the longitudinal axis A _{l s} the main extension Bi of the at least two slots 203 ' being in the plane Pi. A predetermined number of planes Pi with slots 203 ' are provided along the tube 201. Preferably, the width W ₂ of a slot 203 is approximately 0.04 mm.

However, the width W ₂ of a slot 203 may be between 0.01 - 2.0 mm.

[0106] In Figure 27, a cross-section XXVII-XXVII of the tube 201 in Figure 19 illustrates one of the planes Pi perpendicular to the longitudinal axis Ai in the tip region 21 1 with slots. Three slots 203 ' are provided in the plane Pi; however two slots could be used instead. The slots 203 ' in the same perpendicular plane Pi are separated by a slot separation part 204' . The lengths L ₂ of the slots 203 ' in the same perpendicular plane Pi are essentially the same. As further illustrated in Figure 27, the slots 203 ' in the same perpendicular plane Pi are equally distributed around the circumference of the tube 201. The length L ₂ of a slot 203 ' may be defined by a slot angle a ₃ , the slot angle being the center angle of the perpendicular plane Pi. The slot angle is 0° < a ₃ < 160°, preferably about 105°. In Figures 20 and 27, three equally distributed slots 203 ' are provided in each plane Pi. Furthermore, as illustrated in Figure 26, the slots 203 ' in a perpendicular plane Pi are displaced in relation to the slots 203 ' in an adjacent perpendicular plane Pi. The degree of displacement may be any angle between 0° and 120°.

[0107] As illustrated in Figures 26 and 20, adjacent perpendicular planes Pi are separated by a predetermined separation distance. For example, the separation distance d ₄ between adjacent perpendicular planes in Figure 26 may be a constant value, such as a value between about 0.01 mm and about 4.0 mm, preferable about 0.03 mm. The separation distance d ₅ in Figure 20 may be a value between about 0.01 mm and about 4.0 mm, preferably about 0.025 mm. The separation distance between adjacent perpendicular planes may vary such that it decreases (for example, in a linear or other fashion) from the value d ₄ at the proximal end portion of the tip region 21 1 down to the lower value d ₅ at the distal end portion of the tip region 21 1. According to another embodiment, a number of adjacent perpendicular planes at either the proximal or distal end portion of the tip region 211 may be at a constant separation distance from each other. For example, one, two, three, four, twenty, fifty, or more or any integer in-between of the adjacent perpendicular planes at the proximal end portion of the tip region 211 nearest the distal sensor region 210 may have a separation distance from their adjacent perpendicular planes at the higher value d ₄ . Alternatively or additionally, one, two, three, four, twenty, fifty, or more or any integer in-between of the adjacent perpendicular planes at the distal end portion of the tip region 211 farthest from the distal sensor region 210 may have a separation distance from their adjacent perpendicular planes at the lower value d ₃ . According to one embodiment, the predetermined number of perpendicular planes Pi is between 1000 - 10000, preferably the predetermined number of planes Pi is in the interval 1000-5000, and more preferably the predetermined number of planes Pi is approximately 3500.

[0108] In the embodiment of Figures 17-19, the tube 201 may be optionally provided with a coating covering all, or parts of, the slots 203 and 203'. The coating may be made from polyimide, polyurethane, polypropylene, or thermoplastic elastomers, such as a styrene-diene triblock copolymers, polyolefm blend, block copolyurethane, block copoly(ether-ester) and block copoly(ether-amide). In some embodiments, providing the tube 201 with a coating completely covering slots 203 and 203' is advantageous in that it prevents ambient fluid, e.g. blood, from entering into the interior of the tube 201. In other embodiments, the coating may provide either a hydrophilic or hydrophobic outer surface, to optimize the frictional forces between the outer surface of the tube 201 and e.g. the vessel wall or a catheter. This can be accomplished by choosing a material with proper hydrophilic/hydrophobic properties or by surface modification and/or treatment of abovementioned polymeric coating materials.

[0109] According to other embodiments, the proximal regions 9, 109, and 209 may be exchanged for one another among the embodiments of Figures 1-27; the distal sensor regions 10, 110, and 210 may be exchanged for one another among the embodiments of Figures 1-27, the tip regions 11, 111, and 211 may be exchanged for one another among the embodiments of Figures 1-27, or any combination of the proximal regions, distal sensor regions, and tip regions in Figures 1-27 may be used.

[0110] The tube 1, 101, 201 according to any of the above embodiments may be produced by providing an elongated sheet material, e.g. made from steel or nitinol, which is

subsequently bent or shaped into an essentially cylindrical elongated tube 1 , 101, 201. The slots may be provided in the sheet material prior to shaping the sheet material 1, 101, 201 into a tube 1, 101, 201 or after the sheet material has been shaped into a tube 1, 101, 201. The slots may be provided by laser cutting, etching, grinding or by using any other technique suitable to provide slots in the sheet material or the elongated tube 1, 101, 201. The predetermined pattern in the tube 1, 101, 201 may for example be provided by photoetching, which is a process wherein photographic pattern transfer and etch technique are combined.

[0111] According to another embodiment of the present invention, a guide wire and sensor assembly may have an overall distal section of around 320 mm having a slot design for enhanced functionality of the assembly. The overall distal section of this embodiment having the slot design would include a semi-flexible section of around 290 mm (as a distal portion of the proximal region having the slots), a 2.12 mm sensor jacket housing (as the distal sensor region) and a 30 mm tip section (as the tip region). The slot size (width and/or width), the number of slots in a cross section, the slot cut angle and the distance between slots will be changed to suit the required stiffness and flexibility of the distal section of the assembly. This embodiment would contain combination of either two and three slots or only two slots or only three slots along the overall distal section except in the sensor jacket housing. The sensor jacket housing section may include 1-6 slots in a cross section. The slot width would be anything between 0.01 mm and 0.1 mm and the slot cut angle would be between 70° and 160° along the overall distal section having the slot design except in the sensor jacket housing. The angle typically is more relevant to laser cutting process. However when another slot making process is used, the slot circumferential length should be equal to what is defined in the laser processing. The sensor jacket housing would include slots with a width between 0.005 mm and 2 mm and a cut angle between 5° and 180°. The slot position will be rotated along the tube to have predetermined minimum directional properties along the wire. This rotation angle may be in between 0° - 180°. A suitable material for this embodiment would be linear or super elastic nitinol, all type of steel and any metal/alloy whose Young Modulus lies between 50 GPa and 250 GPa. A shape memory properties may be incorporated in the 30 mm tip section by a suitable heat treatment process. The creation of the cut/slots is not limited to a laser cutting process, but any other process creating cut such as etching, EDM and machining could be used. Flexibility, torqueability and tip floppiness are important properties of the guide wire assembly during PCI procedure while the conventional ways to design a guide wire assembly tip with solid metals or material such as stainless steel does not have much freedom to change stiffness along the wire. These conventional designs would also include several parts glued or mechanically joined together.

[0112] For this embodiment, as the flexibility is changed smoothly along the length of the guide wire, friction against the wall will be less, especially in a complex tortuous path, as the bending force against the wall is less. Since the friction is minimized, torque transfer will be improved. Since this embodiment may include a sensor jacket housing and a flexible tip as a single unitary one-piece component without any joint, it possibly eliminates potential torque absorbing points as well as weak mechanical joints. Since this embodiment can include a flexible slotted tip design, there is a possibility to use radioopaque polymer inside the tube.

[0113] Figures 27 and 28 show a section of a tube 301 according to an embodiment of the present invention. The tube section may be provided with a plurality of slots 303. Each slot 303 has an essentially elongated shape along a main extension B ₂ extending along the circumference of the tube section 301. Each slot 303 has a width W ₃ and a length along the main extension B ₂ . At least two slots 303 are provided in a plane P ₂ perpendicular to the longitudinal axis A ₂ , the main extension B ₂ of the at least two slots 303 being in the plane P ₂ . A predetermined number of planes P ₂ with slots 303 are provided along the tube section 301. Preferably, the width W ₂ of a slot 303 may be between 0.01 - 2.0 mm.

[0114] In Figure 29, the cross-section XXIX-XXIX illustrates one of the planes P ₂ perpendicular to the longitudinal axis A ₂ . Two slots 303 are provided in the plane Pi. The slots 303 in the same perpendicular plane P ₂ are separated by a slot separation part 304. The lengths of the slots 303 in the same perpendicular plane P ₂ are essentially the same, and are equally distributed around the circumference of the tube section 301. The length of a slot 303 may be defined by a slot angle a ₄ , the slot angle being the center angle of the perpendicular plane P ₂ . The slot angle is 0° < a ₄ < 160°, preferably about 142.5°.

[0115] In Figure 29, two equally distributed slots 303 are provided in each plane P ₂ .

Furthermore, as illustrated in Figure 28, the slots 303 in a perpendicular plane P ₂ are displaced in relation to the slots 303 in an adjacent perpendicular plane P ₂ . The slots 303 in a perpendicular plane P ₂ are displaced approximately 10° or 60° with respect to each adjacent perpendicular plane Pi. However, the degree of displacement may be any angle between 0° and 120°. [0116] The tube section 303 may be used as a section of a tube in any of the previously- mentioned embodiments. For example, the tube section 303 may be used in place of the section of tube in the proximal region 109 in Figure 9, the tip region 111 in Figure 9, the proximal region 209 in Figure 18, or the tip region 211 in Figure 18.

[0117] Besides those embodiments depicted in the figures and described in the above description, other embodiments of the present invention are also contemplated. For example, any single feature of one embodiment of the present invention may be used in any other embodiment of the present invention. For example, the following is a list of embodiments, but the invention should not be viewed as being limited to these embodiments.

[0118] (I) A tube (1) for an intravascular medical device, said tube (1) having a

longitudinal extension along a longitudinal axis A, and that said tube (1) comprising a tube wall (2) having a specified thickness t, and being provided with a plurality of through-going slots (3),

wherein each slot (3) has an essentially elongated shape along a main extension B extending along the circumference of said tube (1), wherein each slot (3) has a width W and a length L along said main extension B, and

wherein at least two slots (3) are provided in a plane P perpendicular to said longitudinal axis A , said main extension B of said at least two slots (3) being in said plane P, and that a predetermined number of planes P with slots (3) are provided along said tube (1), wherein the lengths L of said slots (3) in the same perpendicular plane P are essentially the same, and that said lengths L of said slots (3) in different planes vary along said longitudinal extension of said tube (1) according to a predefined pattern.

[0119] (II) The tube according to embodiment (I), wherein said slots (3) in said same perpendicular plane P are separated by a slot separation part (4).

[0120] (III) The tube according to any of embodiments (I)-(II), wherein said slots (3) in said same perpendicular plane P are equally distributed around said circumference of said tube (1).

[0121] (IV) The tube according to any of embodiments (I)-(III), wherein according to said predefined pattern said lengths L of said slots (3) decreases in a proximal direction of said tube (1). [0122] (V) The tube according to embodiment (VI), wherein said lengths L of said slots (3) decreases continuously.

[0123] (VI) The tube according to any of the preceding embodiments, wherein according to said predefined pattern said lengths L of said slots (3) are equal in a distal section (5) of said tube (1).

[0124] (VII) The tube according to embodiment (VI), wherein the length L _A , along said longitudinal axis A, of said distal section (5) is approximately 150 mm.

[0125] (VIII) The tube according to any of the preceding embodiments, wherein said length L of a slot (3) is defined by a slot angle a, being the center angle of said perpendicular plane P.

[0126] (IX) The tube according to embodiment (VIII), wherein said slot angle is 0° < a < 160°.

[0127] (X) The tube according to embodiment (IX), wherein said slot angle a is approximately 40° in said distal section (5) of said tube (1).

[0128] (XI) The tube according to any of embodiments (VIII)-(X), wherein said slot angle a decreases from approximately 40° to approximately 0° in a proximal section (6) of said tube (1).

[0129] (XII) The tube according to embodiment (XI), wherein the length LA, along said longitudinal axis A, of said proximal section (6) is approximately 200 mm.

[0130] (XIII) The tube according to any of embodiments (VI)-(VII) or (IX)-(XII), wherein said distal section (5) and said proximal section (6) are arranged adjacent to each other.

[0131] (XIV) The tube according to any of the preceding embodiments, wherein the slots (3) in said perpendicular plane P are displaced in relation to the slots (3) in an adjacent perpendicular plane P.

[0132] (XV) The tube according to any of the preceding embodiments, wherein said tube (1) is adapted to extend at least partly along the length of a guide wire, a sensor guide wire, or a catheter. [0133] (XVI) The tube according to any of the preceding embodiments, wherein said tube (1) is provided with a coating covering all, or parts of, said slots (3).

[0134] (XVII) The tube according to any of the preceding embodiments, wherein adjacent perpendicular planes P are separated by a predetermined separation distance d, being approximately 0.1 mm.

[0135] (XVIII) The tube according to any of the preceding embodiments, wherein said predetermined number of planes P is approximately in the interval 1000-5000.

[0136] (XIX) The tube according to any of the preceding embodiments, wherein said width W of a slot (3) being approximately 0.05 mm.

[0137] (XX) The tube according to any of the preceding embodiments, wherein said tube (3) having an inner diameter of approximately 0.25 mm, and an outer diameter of approximately 0.35 mm.

[0138] (XXI) A sensor guide wire for intravascular measurements of at least one physiological or other variable in a living body, the sensor guide wire (8) having a proximal region (9), a distal sensor region (10) and a tip region (11), the sensor guide wire (8) comprising:

a sensor element (12) arranged in said sensor region (10), and comprising a sensor portion (13), for measuring said variable and to generate a sensor signal in response to said variable,

wherein said sensor guide wire (8) comprises a tube (1) according to any of embodiments (I)-(XX), and in that said tube (1) extends at least partly along said proximal region (9) of said sensor guide wire (8).

[0139] (XXII) A sensor guide wire according to embodiment (XXI), wherein said tube (1) extends at least partly along said distal sensor region (10).

[0140] (XXIII) A sensor guide wire according to embodiment (XXII), wherein said tube (1) is adapted to enclose at least a part of said sensor element (12), and is provided with at least a first sensor opening (7) in said distal sensor region (10).

[0141] (XXIV) A sensor guide wire according to any of embodiments (XXII)-(XXIII), wherein said sensor region (10) is an integrated part of said tube (1). [0142] (XXV) A sensor guide wire according to any of embodiments (XXI)-(XXII), wherein said sensor guide wire is provided with a jacket (15) adapted to enclose at least a part of said sensor element (12), and being provided with at least a first sensor opening (7) in said distal sensor region (10).

[0143] (XXVI) A sensor guide wire according to any of embodiments (XXI)-(XXV), wherein said jacket (15) is attached to said tube (1).

[0144] (XXVII) A sensor guide wire according to any of embodiments (XXI)-(XXVI), wherein no core wire is arranged to extend along said proximal region (9).

[0145] (XXVIII) A sensor guide wire according to any of embodiments (XXI)-(XXVII), wherein no core wire is arranged to extend along said distal sensor region (10).

[0146] (XXIX) A sensor guide wire according to any of embodiments (XXI)-(XXVIII), wherein said proximal section (6) of said tube (1) is arranged in said proximal region (9) of said sensor guide wire (8).

[0147] (XXX) A sensor guide wire according to any of embodiments (XXI)-(XXIX), wherein said distal section (5) of said tube (1) is arranged in said proximal region (9) of said sensor guide wire (8).

[0148] (XXXI) A sensor guide wire according to any of the preceding embodiments, wherein a security string extends from a proximal end to a distal end (14) of said sensor guide wire (8).

[0149] (XXXII) A sensor guide wire according to embodiment (XXXI), wherein said security string is a flexible wire running inside said tube (1).

[0150] The present invention is not limited to the above-described preferred embodiments. Various alternatives, modifications and equivalents may be used. Therefore, the above embodiments should not be taken as limiting the scope of the invention.