Title:
TUMOR ANTIGENS FOR LIVER CANCER IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2021/198449
Kind Code:
A3
Abstract:
The present invention relates to tumor antigens and their use in cancer immunotherapy. In particular, the present invention relates to HERV epitopes and tumor associated antigens (TAAs) expressed by liver cancer cells and which, preferably in combination with epigenetic drugs, can be used in tumor vaccination therapies in the treatment and prevention of liver cancer, preferably hepatocellularcarcinoma (HCC).
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Inventors:
TAGLIAMONTE MARIA (IT)
BUONAGURO LUIGI (IT)
CAVALLUZZO BEATRICE (IT)
MANOLIO CARMEN (IT)
MAURIELLO ANGELA (IT)
RAGONE CONCETTA (IT)
PETRIZZO ANNACARMEN (IT)
BUONAGURO LUIGI (IT)
CAVALLUZZO BEATRICE (IT)
MANOLIO CARMEN (IT)
MAURIELLO ANGELA (IT)
RAGONE CONCETTA (IT)
PETRIZZO ANNACARMEN (IT)
Application Number:
PCT/EP2021/058675
Publication Date:
November 11, 2021
Filing Date:
April 01, 2021
Export Citation:
Assignee:
ISTITUTO NAZ TUMORI IRCCS FONDAZIONE G PASCALE (IT)
International Classes:
A61K39/00; C07K7/06
Domestic Patent References:
| WO2014004385A2 | 2014-01-03 | |||
| WO2020049169A1 | 2020-03-12 |
Other References:
LUIGI BUONAGURO ET AL: "Selecting Target Antigens for Cancer Vaccine Development", VACCINES, vol. 8, no. 4, 17 October 2020 (2020-10-17), pages 615, XP055750726, DOI: 10.3390/vaccines8040615
HARTMANN ERICA M ET AL: "Absolute quantification of norovirus capsid protein in food, water, and soil using synthetic peptides with electrospray and MALDI mass spectrometry", JOURNAL OF HAZARDOUS MATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 286, 5 January 2015 (2015-01-05), pages 525 - 532, XP029146522, ISSN: 0304-3894, DOI: 10.1016/J.JHAZMAT.2014.12.055
DATABASE EPOP [online] 29 April 2019 (2019-04-29), BRIX L: "Sequence 138358 from patent WO2010037395", XP055827688, Database accession no. HC659582
DATABASE Geneseq [online] NCBI; 7 March 2019 (2019-03-07), FOTIN-MLECZEK M ET AL: "Calpain-7 (56-65) SEQ 12808", XP055827708, Database accession no. BFZ93757
LÖFFLER MARKUS W. ET AL: "Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma", GENOME MEDICINE, vol. 11, no. 1, 30 April 2019 (2019-04-30), XP055828059, Retrieved from the Internet DOI: 10.1186/s13073-019-0636-8
RAGONE CONCETTA ET AL: "Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs)", JOURNAL FOR IMMUNOTHERAPY OF CANCER, 1 May 2021 (2021-05-01), pages e002694, XP055827799, Retrieved from the Internet [retrieved on 20210727], DOI: 10.1136/jitc-2021-002694
HARTMANN ERICA M ET AL: "Absolute quantification of norovirus capsid protein in food, water, and soil using synthetic peptides with electrospray and MALDI mass spectrometry", JOURNAL OF HAZARDOUS MATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 286, 5 January 2015 (2015-01-05), pages 525 - 532, XP029146522, ISSN: 0304-3894, DOI: 10.1016/J.JHAZMAT.2014.12.055
DATABASE EPOP [online] 29 April 2019 (2019-04-29), BRIX L: "Sequence 138358 from patent WO2010037395", XP055827688, Database accession no. HC659582
DATABASE Geneseq [online] NCBI; 7 March 2019 (2019-03-07), FOTIN-MLECZEK M ET AL: "Calpain-7 (56-65) SEQ 12808", XP055827708, Database accession no. BFZ93757
LÖFFLER MARKUS W. ET AL: "Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma", GENOME MEDICINE, vol. 11, no. 1, 30 April 2019 (2019-04-30), XP055828059, Retrieved from the Internet
RAGONE CONCETTA ET AL: "Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs)", JOURNAL FOR IMMUNOTHERAPY OF CANCER, 1 May 2021 (2021-05-01), pages e002694, XP055827799, Retrieved from the Internet
Attorney, Agent or Firm:
PACE NAPOLEONE, Maria et al. (IT)
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