Title:
TUMOR MICROENVIRONMENT SPATIAL RELATIONSHIP MODELING SYSTEM AND METHOD BASED ON DIGITAL PATHOLOGY IMAGE
Document Type and Number:
WIPO Patent Application WO/2023/137627
Kind Code:
A1
Abstract:
Disclosed in the present invention are a tumor microenvironment spatial relationship modeling system and method based on a digital pathology image. The system comprises an image dyeing normalization module, configured to determine a pixel distribution type of a pathology image to perform color normalization on the dyeing distribution change to obtain a dyeing normalization image; a structure region segmentation module, configured to detect a region of interest by using a weakly supervised deep learning model for the dyeing normalization image, and then segmenting to obtain a target structure region; a cell detection module, configured to extract information of various types of cells from the target structure region; and a spatial relationship construction module, configured to model a multi-layer network by using a multi-layer graph, to represent a co-spatial distribution among the various types of cells, and perform clustering analysis on the multi-layer graph to obtain a spatial distribution quantitative model. The present invention can accurately reveal the correlation between the intratumoral heterogeneity and the tumor microenvironment cell and tissue spatial distribution rule, thereby providing a new quantitative analysis idea for a tumor evolution mechanism.
Inventors:
QIN WENJIAN (CN)
DIAO SONGHUI (CN)
HE JIAHUI (CN)
HOU JIAXIN (CN)
DIAO SONGHUI (CN)
HE JIAHUI (CN)
HOU JIAXIN (CN)
Application Number:
PCT/CN2022/072760
Publication Date:
July 27, 2023
Filing Date:
January 19, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
G06V20/69; G06V10/26; G06V10/77
Foreign References:
| CN105550651A | 2016-05-04 | |||
| CN113591919A | 2021-11-02 | |||
| CN113674252A | 2021-11-19 | |||
| CN111417958A | 2020-07-14 | |||
| US20180204085A1 | 2018-07-19 |
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
Download PDF:
Previous Patent: DATA LINE AND POWER SUPPLY DEVICE
Next Patent: METHOD FOR MANUFACTURING FILAMENT STRUCTURE HAVING NANOPARTICLES
Next Patent: METHOD FOR MANUFACTURING FILAMENT STRUCTURE HAVING NANOPARTICLES