Title:
TWEAK RECEPTOR
Document Type and Number:
WIPO Patent Application WO2001045730
Kind Code:
A3
Abstract:
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
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Inventors:
WILEY STEVEN R (US)
Application Number:
PCT/US2000/034755
Publication Date:
January 10, 2002
Filing Date:
December 19, 2000
Export Citation:
Assignee:
IMMUNEX CORP (US)
WILEY STEVEN R (US)
WILEY STEVEN R (US)
International Classes:
A61K31/7088; A61K38/00; A61K38/17; A61K39/395; A61K45/00; A61K48/00; G01N33/50; A61P9/00; A61P9/10; A61P9/14; A61P17/02; A61P35/00; A61P37/06; C07K14/705; C07K14/715; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12Q1/02; G01N33/15; G01N33/53; G01N33/566; (IPC1-7): A61K38/17; A61K39/395; C07K14/705; C07K16/28; C12N15/12; A61P35/00
Domestic Patent References:
| WO1998035061A2 | 1998-08-13 | |||
| WO1998055508A2 | 1998-12-10 | |||
| WO1999061471A2 | 1999-12-02 | |||
| WO1994010308A1 | 1994-05-11 | |||
| WO2000042073A1 | 2000-07-20 |
Foreign References:
| US5759546A | 1998-06-02 |
Other References:
KAPLAU M J ET AL: "TH2 LYMPHOCYTES KIL.1 ANTIGEN PRESENTING MACROPHAGES THROUGH A TWEAK DEPENDENT PATHWAY", JOURNAL OF INVESTIGATIVE MEDICINE,US,AMERICAN FEDERATION FOR CLINICAL RESEARCH,, vol. 46, 1998, pages 287A, XP000907589, ISSN: 1081-5589
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