Title:
TWO-LAYER SEPARATION-TYPE EYE DROP CONTAINING SQUALANE
Document Type and Number:
WIPO Patent Application WO/2014/148450
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a technique for formulating a two-layer separation-type eye drop in which, during storage, a water layer and an oil-containing layer containing squalane are separated from each other, wherein it is possible to uniformly disperse the oil-containing layer in the water layer while suppressing foaming by shaking the eye drop before administration, and the uniform dispersed state is maintained in a stable manner at least until administration. A two-layer separation-type eye drop containing squalane and water, wherein hyaluronic acid and/or a salt thereof and polyvinyl alcohol are contained in the eye drop and the polyvinyl alcohol content is set to 0.025 to 0.1 w/v%, whereby it is possible to uniformly disperse the oil-containing layer in the water layer while suppressing foaming by shaking the eye drop before administration, and to maintain the uniform dispersed state in a stable manner at least until administration.
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Inventors:
SAWA SHIROU (JP)
Application Number:
PCT/JP2014/057211
Publication Date:
September 25, 2014
Filing Date:
March 18, 2014
Export Citation:
Assignee:
SENJU PHARMA CO (JP)
International Classes:
A61K31/01; A61K9/10; A61K31/728; A61K47/32
Domestic Patent References:
| WO2006022291A1 | 2006-03-02 | |||
| WO2006009101A1 | 2006-01-26 | |||
| WO2006022291A1 | 2006-03-02 |
Foreign References:
| JP2007211008A | 2007-08-23 | |||
| JPH10218760A | 1998-08-18 | |||
| JP2007211008A | 2007-08-23 |
Other References:
"The Japanese Pharmacopoeia"
"General Rules for Preparations in the Japanese Pharmacopoeia"
See also references of EP 2977044A4
"General Rules for Preparations in the Japanese Pharmacopoeia"
See also references of EP 2977044A4
Attorney, Agent or Firm:
Yamada, Iichiro et al. (JP)
Yamada 威 1 郎 (JP)
Yamada 威 1 郎 (JP)
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