Title:
TYROSINASE INHIBITORS FOR DEPIGMENTATION OR HAIR REMOVAL
Document Type and Number:
WIPO Patent Application WO/2014/056623
Kind Code:
A3
Abstract:
The present application relates to compositions comprising an inhibitor of tyrosinase gene expression, in particular a nucleic acid that is capable of inhibiting gene expression of the tyrosinase gene, and the use thereof for hair removal and/or preventing hair from growing back; and/or the use thereof for depigmentation and/or preventing repigmentation of the skin.
Inventors:
KOSAK HANS (DE)
WEICHERT MARCUS (DE)
WEICHERT MARCUS (DE)
Application Number:
PCT/EP2013/003071
Publication Date:
June 19, 2014
Filing Date:
October 11, 2013
Export Citation:
Assignee:
SECUTECH INTERNAT PTE LTD (SG)
KOSAK HANS (DE)
WEICHERT MARCUS (DE)
KOSAK HANS (DE)
WEICHERT MARCUS (DE)
International Classes:
C12N15/113; A61K31/7088; A61K31/713; A61P17/00; A61Q19/02
Domestic Patent References:
| WO2001058918A2 | 2001-08-16 | |||
| WO2007113531A2 | 2007-10-11 | |||
| WO2005060536A2 | 2005-07-07 | |||
| WO2010149785A1 | 2010-12-29 | |||
| WO2013053480A1 | 2013-04-18 |
Foreign References:
| US20040215006A1 | 2004-10-28 | |||
| US20090081263A1 | 2009-03-26 |
Other References:
SURINTORN BOONANUNTANASARN ET AL: "Molecular Cloning, Gene Expression in Albino Mutants and Gene Knockdown Studies of Tyrosinase mRNA in Rainbow Trout", PIGMENT CELL RESEARCH, vol. 17, no. 4, 12 July 2004 (2004-07-12), pages 413 - 421, XP055050495, ISSN: 0893-5785, DOI: 10.1111/j.1600-0749.2004.00166.x
HIGASHI Y ET AL: "INHIBITION OF TYROSINASE REDUCES CELL VIABILITY IN CATECHOLAMINERGIC NEURONAL CELLS", JOURNAL OF NEUROCHEMISTRY, WILEY INTERSCIENCE, NEW YORK, NY, US, vol. 75, no. 4, October 2000 (2000-10-01), pages 1771 - 1774, XP000952995, ISSN: 0022-3042, DOI: 10.1046/J.1471-4159.2000.0751771.X
LIN SHI-LUNG ET AL: "CHAPTER 4: Recent Application of Intronic MicroRNA Agents in Cosmetics", CURRENT PERSPECTIVES IN MICRORNAS (MIRNA), SPRINGER NETHERLANDS, NL, 2008, pages 51 - 72, XP009136584, ISBN: 978-1-4020-8532-1
N NAKAI ET AL: "Therapeutic RNA interference of malignant melanoma by electrotransfer of small interfering RNA targeting Mitf", GENE THERAPY, vol. 14, no. 4, 5 October 2006 (2006-10-05), pages 357 - 365, XP055049986, ISSN: 0969-7128, DOI: 10.1038/sj.gt.3302868
SANG MI AN ET AL: "Inhibition of melanogenesis by tyrosinase siRNA in human melanocytes", BMB REPORTS, vol. 42, no. 3, 31 March 2009 (2009-03-31), pages 178 - 183, XP055050489
IWAKIRI R ET AL: "Suppression of Mitf by small interfering RNA induces dedifferentiation of chick embryonic retinal pigment epithelium", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD, LONDON, vol. 81, no. 1, 4 February 2005 (2005-02-04), pages 15 - 21, XP004939247, ISSN: 0014-4835, DOI: 10.1016/J.EXER.2005.01.004
HIGASHI Y ET AL: "INHIBITION OF TYROSINASE REDUCES CELL VIABILITY IN CATECHOLAMINERGIC NEURONAL CELLS", JOURNAL OF NEUROCHEMISTRY, WILEY INTERSCIENCE, NEW YORK, NY, US, vol. 75, no. 4, October 2000 (2000-10-01), pages 1771 - 1774, XP000952995, ISSN: 0022-3042, DOI: 10.1046/J.1471-4159.2000.0751771.X
LIN SHI-LUNG ET AL: "CHAPTER 4: Recent Application of Intronic MicroRNA Agents in Cosmetics", CURRENT PERSPECTIVES IN MICRORNAS (MIRNA), SPRINGER NETHERLANDS, NL, 2008, pages 51 - 72, XP009136584, ISBN: 978-1-4020-8532-1
N NAKAI ET AL: "Therapeutic RNA interference of malignant melanoma by electrotransfer of small interfering RNA targeting Mitf", GENE THERAPY, vol. 14, no. 4, 5 October 2006 (2006-10-05), pages 357 - 365, XP055049986, ISSN: 0969-7128, DOI: 10.1038/sj.gt.3302868
SANG MI AN ET AL: "Inhibition of melanogenesis by tyrosinase siRNA in human melanocytes", BMB REPORTS, vol. 42, no. 3, 31 March 2009 (2009-03-31), pages 178 - 183, XP055050489
IWAKIRI R ET AL: "Suppression of Mitf by small interfering RNA induces dedifferentiation of chick embryonic retinal pigment epithelium", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD, LONDON, vol. 81, no. 1, 4 February 2005 (2005-02-04), pages 15 - 21, XP004939247, ISSN: 0014-4835, DOI: 10.1016/J.EXER.2005.01.004
Attorney, Agent or Firm:
EHNIS, Tobias (Marie-Curie-Str. 1, Erlangen, DE)
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