ULTRA LIGHT-SENSITIVE NEUROPSIN-BASED OPTOGENETIC TOOL FOR ACTIVATING G q-COUPLED SIGNALING AND/OR ACTIVATING CELLS - NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING

Title:

ULTRA LIGHT-SENSITIVE NEUROPSIN-BASED OPTOGENETIC TOOL FOR ACTIVATING G q-COUPLED SIGNALING AND/OR ACTIVATING CELLS

Document Type and Number:

WIPO Patent Application WO/2023/116720

Kind Code:

A1

Abstract:

The present invention relates to an isolated light-sensitive opsin for rapidly, reversibly, and precisely activating G q signaling and/or activating cells.

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Inventors:

YU TAO (CN)
DAI RUICHENG (CN)
WENG DANWEI (CN)
LUO MINMIN (CN)

Application Number:

PCT/CN2022/140440

Publication Date:

June 29, 2023

Filing Date:

December 20, 2022

Export Citation:

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Assignee:

NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN)

International Classes:

C07K14/47; A61K38/17; A61N5/06; A61P25/00

Domestic Patent References:

WO2020188572A1	2020-09-24
WO2021074606A1	2021-04-22
WO2021105509A1	2021-06-03

Foreign References:

US20160361437A1

2016-12-15

Other References:

DATABASE NUCLEOTIDE ANONYMOUS : "Gallus gallus opsin 5 (OPN5), mRNA", XP093077407, retrieved from NCBI
DATABASE NUCLEOTIDE ANONYMOUS : "PREDICTED: Chelonia mydas opsin 5 (OPN5), mRNA", XP093077411, retrieved from NCBI