Title:
ULTRASONIC-RESPONSIVE PORPHYRIN-LIPOSOME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/019542
Kind Code:
A1
Abstract:
The present invention relates to ultrasonic-responsive porphyrin-liposomes capable of releasing drugs in response to ultrasound. The ultrasonic-responsive porphyrin-liposomes of the present invention contain porphyrin. When exposed to ultrasound, the porphyrin reacts with water to generate reactive oxygen species. The phospholipids constituting the lipid bilayer of the porphyrin-liposomes react with the reactive oxygen species produced by the porphyrin to invoke lipid peroxidation, which consequently leads to the collapse of the lipid bilayer structure, allowing the enclosed drugs to be released.
Inventors:
JUNG EUN AH (KR)
KIM DAEHYUN (KR)
KIM DAEHYUN (KR)
Application Number:
PCT/KR2023/010440
Publication Date:
January 25, 2024
Filing Date:
July 19, 2023
Export Citation:
Assignee:
IMGT CO LTD (KR)
International Classes:
A61K9/00; A61K9/127; A61K41/00; A61P35/00
Foreign References:
| KR20180120671A | 2018-11-06 | |||
| KR20190001022A | 2019-01-04 | |||
| JP2017105805A | 2017-06-15 | |||
| JP2005041869A | 2005-02-17 |
Other References:
WANG XIAOBING; YAN FEI; LIU XIUFANG; WANG PAN; SHAO SHUAI; SUN YUE; SHENG ZONGHAI; LIU QUANHONG; LOVELL JONATHAN F.; ZHENG HAIRONG: "Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 286, 1 August 2018 (2018-08-01), AMSTERDAM, NL , pages 358 - 368, XP085478004, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.07.048
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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