Title:
ULTRASONICALLY-ENHANCED CONTINUOUS AND LARGE-SCALE PRODUCTION METHOD FOR NANO-FORMULATIONS
Document Type and Number:
WIPO Patent Application WO/2023/109836
Kind Code:
A1
Abstract:
Disclosed is an ultrasonically-enhanced continuous and large-scale production method for nano-formulations. Specifically disclosed is a preparation system for continuous production of nano-formulations, comprising (a) a first pipe, (b) a second pipe, (f) an ultrasonic device, (c) a combined pipe and (e) a (fluid) outlet thereof. The first pipe and the second pipe are connected to the combined pipe. A first phase solution enters the combined pipe through a first pipe outlet, and a second phase solution enters the combined pipe through a second pipe outlet. The ultrasonic device acts on the part or the whole of the combined pipe. The first phase solution and the second phase solution are turbulently mixed in the combined pipe to form a combined phase, and flow out through the outlet of the combined pipe. The preparation system and the preparation method of the present invention can remarkably improve the entrapment efficiency of nano-drugs, and improve the uniformity of the particle size of nano-particles.
Inventors:
ZHANG FUYAO (CN)
WAN JIAXUN (CN)
WAN JIAXUN (CN)
Application Number:
PCT/CN2022/138806
Publication Date:
June 22, 2023
Filing Date:
December 13, 2022
Export Citation:
Assignee:
SHANGHAI BEST LINK BIOSCIENCE LLC (CN)
International Classes:
A61J3/00; A61K9/08; A61K9/107; A61K9/127; A61K31/4745; A61K41/00; A61K45/00; A61P35/00; B82Y5/00
Domestic Patent References:
| WO2020263179A1 | 2020-12-30 |
Foreign References:
| CN111819217A | 2020-10-23 | |||
| CN112236459A | 2021-01-15 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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