Title:
ULTRAVIOLET LIGHT TRIGGERED CROSSLINKING NEAR-INFRARED MOLECULAR PROBE AND PREPARATION METHOD AND APPLICATION THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/024302
Kind Code:
A1
Abstract:
Provided are an ultraviolet light triggered crosslinking near-infrared molecular probe and a preparation method and an application therefor. The preparation method comprises the following steps: constructing and synthesising a photo-crosslinking near-infrared molecular probe DACF; triggered by ultraviolet light, the photo-crosslinking near-infrared molecular probe DACF implements crosslinking in cells. The probe is irradiated by light of a specific wavelength to produce a highly active carbene intermediate that bonds covalently to intracellular biomolecules, significantly increasing the intake of the probe in the cells and extending the retention time, and being capable of implementing long-term tracking of tumour cells. In addition, using the photothermal effect of the probe can better kill tumour cells. The photo-crosslinking near-infrared molecular probe DACF obtained by the present preparation method can effectively increase the enrichment and retention time of the probe in living tumours, integrating the diagnosis and treatment of tumours, and having important scientific research and economic value.
Inventors:
SHI HAIBIN (CN)
SUN RUI (CN)
SUN RUI (CN)
Application Number:
PCT/CN2018/098682
Publication Date:
February 06, 2020
Filing Date:
August 03, 2018
Export Citation:
Assignee:
ZHANGJIAGANG INST IND TECH SOOCHOW UNIV (CN)
UNIV SOOCHOW (CN)
UNIV SOOCHOW (CN)
International Classes:
C07D487/04; A61K31/519; A61P35/00; C09B23/08
Foreign References:
| CN109180680A | 2019-01-11 | |||
| CN102532197A | 2012-07-04 | |||
| CN103435648A | 2013-12-11 |
Other References:
SAKURAI, K. ET AL.: "Design and Synthesis of Fluorescent Glycolipid Photoaffinity Probes anc Their Photoreactivity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, 21 August 2016 (2016-08-21), pages 5110 - 5115, XP055605553, DOI: 10.1016/j.bmcl.2016.08.053
SAKURAI, K. ET AL.: "Photoaffinity Labeling Studies of the Carbohydrate-Binding Proteins with Different Affinities", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, 31 July 2015 (2015-07-31), pages 5319 - 5325, XP055680739
SAKURAI, K. ET AL.: "Photoaffinity Labeling Studies of the Carbohydrate-Binding Proteins with Different Affinities", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, 31 July 2015 (2015-07-31), pages 5319 - 5325, XP055680739
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
Download PDF:
Previous Patent: METHOD AND DEVICE FOR ENSURING DATA TRANSMISSION RELIABILITY, AND NETWORK APPARATUS
Next Patent: DATA COLLECTION METHOD AND APPARATUS
Next Patent: DATA COLLECTION METHOD AND APPARATUS