Title:
UNSATURATED 5-MEMBER HETEROCYCLE COMPOUNDS, USES AND PREPARATION METHODS THEIROF
Document Type and Number:
WIPO Patent Application WO/2007/095851
Kind Code:
A1
Abstract:
The present invention has disclosed a set of pentac unsaturated heterocycle compounds which can up accommodate the expression activity of Osteogenesis protein BMP-2 to increase the bone density, and inhibit cholesterol biosynthesis to reduce blood fats. The present invention has disclosed the synthesis of a set of pentac unsaturated heterocycle compounds and has measured their upper opsonization of Osteogenesis protein BMP-2 and inhibiting effect on key fat metabolism enzyme HMG-CoA. It lays the foundation of treatment of diseases relating to bone metabolic disorders or blood fat metabolic disorders of mentioned compounds.
Inventors:
LI ZHUORONG (CN)
ZHANG YUEQIN (CN)
LIU ZONGYING (CN)
SI SHUYI (CN)
YANG ZHAOYONG (CN)
SHAO HUAYI (CN)
YANG JUN (CN)
ZHANG YUEQIN (CN)
LIU ZONGYING (CN)
SI SHUYI (CN)
YANG ZHAOYONG (CN)
SHAO HUAYI (CN)
YANG JUN (CN)
Application Number:
PCT/CN2007/000535
Publication Date:
August 30, 2007
Filing Date:
February 14, 2007
Export Citation:
Assignee:
INST MEDICINAL BIOTECHNOLOGY (CN)
LI ZHUORONG (CN)
ZHANG YUEQIN (CN)
LIU ZONGYING (CN)
SI SHUYI (CN)
YANG ZHAOYONG (CN)
SHAO HUAYI (CN)
YANG JUN (CN)
LI ZHUORONG (CN)
ZHANG YUEQIN (CN)
LIU ZONGYING (CN)
SI SHUYI (CN)
YANG ZHAOYONG (CN)
SHAO HUAYI (CN)
YANG JUN (CN)
International Classes:
C07D207/30; A61K31/341; A61K31/381; A61K31/40; A61P19/00; C07D207/323; C07D307/34; C07D307/40; C07D333/06
Domestic Patent References:
| WO2005027900A1 | 2005-03-31 |
Foreign References:
| US3989713A | 1976-11-02 | |||
| EP0025202A2 | 1981-03-18 | |||
| CN1088205A | 1994-06-22 | |||
| US6653346B1 | 2003-11-25 | |||
| US3917871A | 1975-11-04 |
Other References:
RICHARD F. ET AL.: "Zeolite-catalyzed acylation of heterocyclic compounds - VI. One-step synthesis of 3-(benzofuran-2-carbonyl)pentane-2,4-dione from 2-acetylbenzofuran over HY-zeolite", TETRAHEDRON, vol. 54, no. 49, 1998, pages 14757 - 14766
DATABASE CAPLUS [online] Database accession no. (87:151914)
DATABASE CAPLUS [online] Database accession no. (87:151914)
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (Block A Corporate Squar, No.35 Jinrong Street Beijing 2, CN)
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