Title:
USE OF 13-HODE AS A REGULATOR OF VASCULAR BIOCOMPATIBILITY AND AN INHIBITOR OF CELL HYPERPLASIA
Document Type and Number:
WIPO Patent Application WO2001076568
Kind Code:
A3
Abstract:
This invention relates to the regulation of vascular endothelium biocompatibility and to the inhibition of vessel wall cell and other types of cell hyperplasia following vessel wall dysfunction and/or injury. More particularly, the invention relates to the dietetic and pharmaceutical preparations of 13-hydroxyoctadeca-9Z, 11E-dienoic acid (13-HODE) and its use in reducing or inhibiting vessel wall hyperplasia and restoring vessel wall biocompatibility.
Inventors:
BUCHANAN MICHAEL R (CA)
HORROBIN DAVID (GB)
HORROBIN DAVID (GB)
Application Number:
PCT/CA2001/000477
Publication Date:
September 26, 2002
Filing Date:
April 06, 2001
Export Citation:
Assignee:
1411198 ONTARIO LTD (CA)
BUCHANAN MICHAEL R (CA)
HORROBIN DAVID (GB)
BUCHANAN MICHAEL R (CA)
HORROBIN DAVID (GB)
International Classes:
A61K31/201; A61K47/14; A61K47/44; A61P1/00; A61P3/10; A61P11/00; A61P13/00; A61P15/00; A61P17/00; A61P25/00; A61P29/00; A61P35/00; A61P37/00; (IPC1-7): A61K31/00; A61K31/201; A61K31/66; A61K31/375; A61K31/355; A61K47/44; A61K47/14; A61P9/00; A61P29/00; A61P37/00; A61P31/00; A61P11/00; A61P1/00; A61P13/00; A61P17/00; A61P25/00; A61P15/00; A61P3/10; A61P35/00
Domestic Patent References:
| WO1999059562A2 | 1999-11-25 | |||
| WO1999018956A1 | 1999-04-22 | |||
| WO1999044585A1 | 1999-09-10 | |||
| WO2001003688A2 | 2001-01-18 | |||
| WO2000055318A2 | 2000-09-21 |
Foreign References:
| EP0955047A2 | 1999-11-10 | |||
| US5102912A | 1992-04-07 | |||
| EP0209066A1 | 1987-01-21 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 012, no. 005 (C - 467) 8 January 1988 (1988-01-08)
DATABASE WPI Week 199602, Derwent World Patents Index; AN 1996-017135, XP002180908, KAMINAKAI KAZUO ET AL.: "Antitumor agent and its production"
TRUITT ANNE ET AL: "Antiplatelet effects of conjugated linoleic acid isomers.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1438, no. 2, 18 May 1999 (1999-05-18), pages 239 - 246, XP000852565, ISSN: 0006-3002
TLOTI M A ET AL: "EFFECT OF 13 HYDROXYOCTADECA-9 11-DIENOIC ACID 13-HODE ON THROMBIN INDUCED PLATELET ADHERENCE TO ENDOTHELIAL CELLS IN-VITRO", THROMBOSIS RESEARCH, vol. 62, no. 4, 1991, pages 305 - 318, XP001034240, ISSN: 0049-3848
BUCHANAN M R ET AL: "Prevention and treatment of thrombosis: Novel strategies arising from our understanding the healthy endothelium.", WIENER KLINISCHE WOCHENSCHRIFT, vol. 105, no. 11, 1993, pages 309 - 313, XP001034244, ISSN: 0043-5325
BERTOMEU M C ET AL: "SELECTIVE EFFECTS OF DIETARY FATS ON VASCULAR 13-HODE SYNTHESIS AND PLATELET-VESSEL WALL INTERACTIONS", THROMBOSIS RESEARCH, vol. 59, no. 5, 1990, pages 819 - 830, XP001034239, ISSN: 0049-3848
BRISTER S J ET AL: "13 HODE SYNTHESIS IN INTERNAL MAMMARY ARTERIES AND SAPHENOUS VEINS IMPLICATIONS IN CARDIOVASCULAR SURGERY", ADVANCES IN PROSTAGLANDIN THROMBOXANE AND LEUKOTRIENE RESEARCH, 1991, pages 667 - 670, XP001034324, ISSN: 0732-8141
BUCHANAN M R ET AL: "13-HODE prevents vascular hyperplasia and subsequent occlusion in rabbits following vessel wall injury.", CANADIAN JOURNAL OF CARDIOLOGY, vol. 16, no. Supplement F, September 2000 (2000-09-01), 53rd Annual Meeting of the Canadian Cardiovascular Society;Vancouver, British Columbia, Canada; October 20-November 01, 2000, pages 150F, XP001034267, ISSN: 0828-282X
DATABASE WPI Week 199602, Derwent World Patents Index; AN 1996-017135, XP002180908, KAMINAKAI KAZUO ET AL.: "Antitumor agent and its production"
TRUITT ANNE ET AL: "Antiplatelet effects of conjugated linoleic acid isomers.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1438, no. 2, 18 May 1999 (1999-05-18), pages 239 - 246, XP000852565, ISSN: 0006-3002
TLOTI M A ET AL: "EFFECT OF 13 HYDROXYOCTADECA-9 11-DIENOIC ACID 13-HODE ON THROMBIN INDUCED PLATELET ADHERENCE TO ENDOTHELIAL CELLS IN-VITRO", THROMBOSIS RESEARCH, vol. 62, no. 4, 1991, pages 305 - 318, XP001034240, ISSN: 0049-3848
BUCHANAN M R ET AL: "Prevention and treatment of thrombosis: Novel strategies arising from our understanding the healthy endothelium.", WIENER KLINISCHE WOCHENSCHRIFT, vol. 105, no. 11, 1993, pages 309 - 313, XP001034244, ISSN: 0043-5325
BERTOMEU M C ET AL: "SELECTIVE EFFECTS OF DIETARY FATS ON VASCULAR 13-HODE SYNTHESIS AND PLATELET-VESSEL WALL INTERACTIONS", THROMBOSIS RESEARCH, vol. 59, no. 5, 1990, pages 819 - 830, XP001034239, ISSN: 0049-3848
BRISTER S J ET AL: "13 HODE SYNTHESIS IN INTERNAL MAMMARY ARTERIES AND SAPHENOUS VEINS IMPLICATIONS IN CARDIOVASCULAR SURGERY", ADVANCES IN PROSTAGLANDIN THROMBOXANE AND LEUKOTRIENE RESEARCH, 1991, pages 667 - 670, XP001034324, ISSN: 0732-8141
BUCHANAN M R ET AL: "13-HODE prevents vascular hyperplasia and subsequent occlusion in rabbits following vessel wall injury.", CANADIAN JOURNAL OF CARDIOLOGY, vol. 16, no. Supplement F, September 2000 (2000-09-01), 53rd Annual Meeting of the Canadian Cardiovascular Society;Vancouver, British Columbia, Canada; October 20-November 01, 2000, pages 150F, XP001034267, ISSN: 0828-282X
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