Title:
USE OF ACTIVE ANDROGEN RECEPTOR ANTAGONIST FOR CANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO/2021/221447
Kind Code:
A1
Abstract:
The present invention relates to a use of an active androgen receptor antagonist for cancer treatment. Specifically, an oligonucleotide KilGreene according to the present invention comprises a Kil sequence and a distal glucocorticoid response element (GRE), wherein an active androgen receptor binds to the GRE, and a signal peptide interacting with the active androgen receptor binds to the Kil sequence, so that a complex of the active androgen receptor and signal peptide interacting therewith can be removed. Therefore, KilGreene exhibits effects of removing an active androgen receptor moved into the nucleus through EGFR-induced androgen-independent signaling in non-small cell lung cancer cells that are positive for EGFR, so as to block the transcription activation of the active androgen receptor, and thus inhibits the growth of cancer cells. Thus, KilGreene is a gene therapy agent and can be usefully used as an active ingredient in the treatment of cancer associated with androgen receptor signaling.
Inventors:
LEE KYUNG IL (KR)
Application Number:
PCT/KR2021/005341
Publication Date:
November 04, 2021
Filing Date:
April 27, 2021
Export Citation:
Assignee:
LEE KYUNG IL (KR)
International Classes:
A61K48/00; A61K31/713; A61P35/00
Foreign References:
| KR950703056A | 1995-08-23 | |||
| KR102231066B1 | 2021-03-23 |
Other References:
ANILMIS NUR MERVE, KARA GOKNUR, KILICAY EBRU, HAZER BAKI, DENKBAS EMIR BAKI: "Designing siRNA-conjugated plant oil-based nanoparticles for gene silencing and cancer therapy", JOURNAL OF MICROENCAPSULATION, vol. 36, no. 7, 3 October 2019 (2019-10-03), Taylor & Francis Ltd, pages 635 - 648, XP009531542, ISSN: 0265-2048, DOI: 10.1080/02652048.2019.1665117
LEE KYONG-IL PREMKUMAR, E. PREMKUMAR REDDY, C. DAMODARA REDDY: "Cellular Factors Binding to a Novel cis-Acting Element Mediate Steroid Hormone Responsiveness of Mouse Mammary Tumor Virus Promoter*", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 41, 1 October 1995 (1995-10-01), pages 24502 - 24508, XP055863941, DOI: 10.1074/jbc.270.41.24502
SONG J, CHO SJ, LEE KI, KIM SH, KANG JS, LEE KW, LEE JY, KU PS: "Suppression of Steroid Receptor Function by Retinoblastoma Protein in Breast Cancer Cell Line, MCF 7", KOREAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 40, no. 10, 1 October 1997 (1997-10-01), Korea, pages 2269 - 2278, XP009531544, ISSN: 0494-4755
LEE KYONG-IL PREMKUMAR, E. PREMKUMAR REDDY, C. DAMODARA REDDY: "Cellular Factors Binding to a Novel cis-Acting Element Mediate Steroid Hormone Responsiveness of Mouse Mammary Tumor Virus Promoter*", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 41, 1 October 1995 (1995-10-01), pages 24502 - 24508, XP055863941, DOI: 10.1074/jbc.270.41.24502
SONG J, CHO SJ, LEE KI, KIM SH, KANG JS, LEE KW, LEE JY, KU PS: "Suppression of Steroid Receptor Function by Retinoblastoma Protein in Breast Cancer Cell Line, MCF 7", KOREAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 40, no. 10, 1 October 1997 (1997-10-01), Korea, pages 2269 - 2278, XP009531544, ISSN: 0494-4755
Attorney, Agent or Firm:
KIM, Bo Jung (KR)
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