USE OF AEROSOLIZED ANTITHROMBIN TO TREAT ACUTE LUNG INJURY

Title:

USE OF AEROSOLIZED ANTITHROMBIN TO TREAT ACUTE LUNG INJURY

Document Type and Number:

WIPO Patent Application WO2005072139

Kind Code:

A3

Abstract:

The invention features methods of treating a subject having a lung disorder such as lung inflammation and injury, by administering antithrombin III through pulmonary delivery.

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Inventors:

MURAKAMI KAZUNORI (US)
ENKHBAATAR PERENLEI (US)
COX ROBERT A (US)
HAWKINS HAL A (US)
TRABER LILLIAN D (US)
TRABER DANIEL L (US)

Application Number:

PCT/US2005/001238

Publication Date:

January 05, 2006

Filing Date:

January 14, 2005

Export Citation:

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Assignee:

GTC BIOTHERAPEUTICS INC (US)
MURAKAMI KAZUNORI (US)
ENKHBAATAR PERENLEI (US)
COX ROBERT A (US)
HAWKINS HAL A (US)
TRABER LILLIAN D (US)
TRABER DANIEL L (US)

International Classes:

A61K38/48; A61K38/57; A61L9/04; (IPC1-7): A61K38/48

Foreign References:

US20030007966A1	2003-01-09
US5843705A	1998-12-01

Other References:

UCHIBA ET AL: "Effects of varius doses antithrombin III endotoxin induced endothelial cell injury and coagulation abnormalities in rats.", THROMBOSIS RESEARCH., vol. 89, March 1989 (1989-03-01), pages 233 - 241
HUANG ET AL: "Thrombin promotes fibroblast proliferation during the early stages of experimental radiation Pneumonitis.", RADIATION RESEARCH., vol. 156, 2001, pages 45 - 52

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