Title:
USE OF COMPOUND BINDING TO MSIN3B THAT SPECIFICALLY BINDS TO NEURON RESTRICTIVE SILENCER FACTOR (NRSF)
Document Type and Number:
WIPO Patent Application WO/2011/099502
Kind Code:
A1
Abstract:
The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to a neuron restrictive silencer factor (NRSF), and provides a use of the compound as a prophylactic and/or therapeutic agent for diseases associated with aberrant expression of a neuron restrictive silencer binding factor (NRSF/REST) or aberrant expression of a gene targeted by the NRSF/REST, such as Huntington's disease, medulloblastoma and neuropathic pain. Specifically disclosed is a pharmaceutical composition which contains a substance that is capable of binding to the PAH1 domain of mSin3B, for example, a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof. (In the formula, n represents 0 or 1; R1, R2, R3, R4 and R5 each independently represents a hydrogen atom, a hydrocarbon group or a functional group; Y represents a single bond, a carbonyl group, a -CONH- group, an -NHCO- group or a sulfonyl group; and Z represents an optionally substituted nitrogen-containing heterocyclic group, an amino group which may have a hydrocarbon group or an aromatic hydrocarbon group, or an optionally substituted nitrogen- and oxygen-containing heterocyclic group.)
Inventors:
NISHIMURA YOSHIFUMI (JP)
NAGADOI ARITAKA (JP)
HIRAO YUUKA (JP)
GOSHIMA YOSHIO (JP)
YAMASHITA NAOYA (JP)
MIYATA NAOKI (JP)
SUZUKI TAKAYOSHI (JP)
HIRAISHI RYUTA (JP)
UEDA HIROSHI (JP)
NAGADOI ARITAKA (JP)
HIRAO YUUKA (JP)
GOSHIMA YOSHIO (JP)
YAMASHITA NAOYA (JP)
MIYATA NAOKI (JP)
SUZUKI TAKAYOSHI (JP)
HIRAISHI RYUTA (JP)
UEDA HIROSHI (JP)
Application Number:
PCT/JP2011/052710
Publication Date:
August 18, 2011
Filing Date:
February 09, 2011
Export Citation:
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY (JP)
UNIV NAGASAKI (JP)
UNIV NAGOYA CITY (JP)
NISHIMURA YOSHIFUMI (JP)
NAGADOI ARITAKA (JP)
HIRAO YUUKA (JP)
GOSHIMA YOSHIO (JP)
YAMASHITA NAOYA (JP)
MIYATA NAOKI (JP)
SUZUKI TAKAYOSHI (JP)
HIRAISHI RYUTA (JP)
UEDA HIROSHI (JP)
UNIV NAGASAKI (JP)
UNIV NAGOYA CITY (JP)
NISHIMURA YOSHIFUMI (JP)
NAGADOI ARITAKA (JP)
HIRAO YUUKA (JP)
GOSHIMA YOSHIO (JP)
YAMASHITA NAOYA (JP)
MIYATA NAOKI (JP)
SUZUKI TAKAYOSHI (JP)
HIRAISHI RYUTA (JP)
UEDA HIROSHI (JP)
International Classes:
A61K45/00; A61K31/445; A61P3/10; A61P9/00; A61P17/00; A61P25/14; A61P25/16; A61P25/28; A61P35/00; A61P37/08; C07D211/14; C07D211/16
Domestic Patent References:
| WO2007106706A1 | 2007-09-20 | |||
| WO2009016088A1 | 2009-02-05 | |||
| WO2006020681A2 | 2006-02-23 | |||
| WO2006030722A1 | 2006-03-23 |
Foreign References:
| JP2006522746A | 2006-10-05 | |||
| JP2009529577A | 2009-08-20 | |||
| JP2007533682A | 2007-11-22 | |||
| US3206439A | 1965-09-14 | |||
| JPH11501319A | 1999-02-02 | |||
| JP2006524637A | 2006-11-02 | |||
| JP2009536155A | 2009-10-08 | |||
| JP2010027066A | 2010-02-04 |
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KIM SM; YANG JW; PARK MJ; LEE JK; KIM SU; LEE YS; LEE MA: "Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor", BBRC, vol. 346, 2006, pages 426
NEUROSCIENCE RESEARCH, pages 65 - 236
KURSCHAT P; BIELENBERG D; ROSSIGNOL-TALLANDIER M; STAHL A; KLAGSBRUN M: "Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration", J BIOL CHEM., vol. 281, no. 5, 5 December 2005 (2005-12-05), pages 2721 - 9
MARTIN D; TAWADROS T; MEYLAN L; ABDERRAHMANI A; CONDORELLI DF; WAEBER G; HAEFLIGER JA: "Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines", J BIOL CHEM., vol. 278, no. 52, 16 October 2003 (2003-10-16), pages 53082 - 9
K. KUWAHARA; Y SAITO; M. TAKANO; Y. ARAI; S. YASUNO; Y. NAKAGAWA; N. TAKAHASHI; Y. ADACHI; G. TAKEMURA; M. HORIE: "NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function", THE EMBO JOURNAL, vol. 22, 2003, pages 6310 - 6321
INOUE ET AL., NATURE MEDICINE, vol. 10, 2004, pages 712 - 718
MATSUMOTO ET AL., J PHARMACOL EXP THER, vol. 318, 2006, pages 735 - 740
UEDA, MOL PAIN, vol. 4, 2008, pages 11
BAHN S ET AL., LANCET, vol. 359, 2002, pages 310 - 315
OKAZAKI T ET AL., NEUROBIOL AGING, vol. 16, 1995, pages 883 - 894
LAWINGER P ET AL., NATURE MED., vol. 7, 2000, pages 826 - 831
ZUCCATO C ET AL., NATURE GENETICS, vol. 35, 2003, pages 76 - 83
NARUSE Y ET AL., PROC.NATL ACAD. SCI. USA, vol. 96, 1999, pages 13691 - 13696
J. MOL. BIOL., vol. 354, 2005, pages 903 - 915
UCHIDA ET AL., NEUROSCIENCE, vol. 166, 2010, pages 1 - 4
UCHIDA ET AL., J NEUROSCI, vol. 30, 2010, pages 4806 - 4814
UEDA, PHARMACOL THER, vol. 109, 2006, pages 57 - 77
DATABASE CAPLUS 11 April 2011 (2011-04-11), SRIVASTAVA V. ET AL: "Evaluation of some acylamide derivatives as potential hypoglycemic agents", accession no. STN Database accession no. 126:139503
DATABASE CAPLUS 11 April 2011 (2011-04-11), SAM J. ET AL: "Preparation of some N-benzylpiperidines", accession no. STN Database accession no. 68:95646
PALMER D.H. ET AL: "Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil", BR. J. CANCER, vol. 89, no. 5, 2003, pages 944 - 950, XP055096340
BENOIT-GUYOD M. ET AL: "Dipropylacetic acid series. IX. Structural homologs: 1-methyl-2-propylpentylamine, and substituted amides and ureas", CHIMICA THERAPEUTICA, vol. 8, no. 4, 1973, pages 412 - 418, XP008075252
DATABASE CAPLUS 8 April 2011 (2011-04-08), PAGANI G. ET AL: "Phytotoxic activity of di-sec-butylamides of alkyl-and halonitrobenzoic acids", accession no. STN Database accession no. 80:729
DATABASE REGISTRY 27 April 2001 (2001-04-27), accession no. STN Database accession no. RN 333350-41-7
DATABASE REGISTRY 15 July 2001 (2001-07-15), accession no. STN Database accession no. RN 438529-71-6
DATABASE REGISTRY 27 April 2001 (2001-04-27), accession no. STN Database accession no. RN 333350-40-6
DATABASE REGISTRY 17 November 2000 (2000-11-17), accession no. STN Database accession no. RN 303137-53-3
KIM SM; YANG JW; PARK MJ; LEE JK; KIM SU; LEE YS; LEE MA: "Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor", BBRC, vol. 346, 2006, pages 426
NEUROSCIENCE RESEARCH, pages 65 - 236
KURSCHAT P; BIELENBERG D; ROSSIGNOL-TALLANDIER M; STAHL A; KLAGSBRUN M: "Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration", J BIOL CHEM., vol. 281, no. 5, 5 December 2005 (2005-12-05), pages 2721 - 9
MARTIN D; TAWADROS T; MEYLAN L; ABDERRAHMANI A; CONDORELLI DF; WAEBER G; HAEFLIGER JA: "Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines", J BIOL CHEM., vol. 278, no. 52, 16 October 2003 (2003-10-16), pages 53082 - 9
K. KUWAHARA; Y SAITO; M. TAKANO; Y. ARAI; S. YASUNO; Y. NAKAGAWA; N. TAKAHASHI; Y. ADACHI; G. TAKEMURA; M. HORIE: "NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function", THE EMBO JOURNAL, vol. 22, 2003, pages 6310 - 6321
INOUE ET AL., NATURE MEDICINE, vol. 10, 2004, pages 712 - 718
MATSUMOTO ET AL., J PHARMACOL EXP THER, vol. 318, 2006, pages 735 - 740
UEDA, MOL PAIN, vol. 4, 2008, pages 11
BAHN S ET AL., LANCET, vol. 359, 2002, pages 310 - 315
OKAZAKI T ET AL., NEUROBIOL AGING, vol. 16, 1995, pages 883 - 894
LAWINGER P ET AL., NATURE MED., vol. 7, 2000, pages 826 - 831
ZUCCATO C ET AL., NATURE GENETICS, vol. 35, 2003, pages 76 - 83
NARUSE Y ET AL., PROC.NATL ACAD. SCI. USA, vol. 96, 1999, pages 13691 - 13696
J. MOL. BIOL., vol. 354, 2005, pages 903 - 915
UCHIDA ET AL., NEUROSCIENCE, vol. 166, 2010, pages 1 - 4
UCHIDA ET AL., J NEUROSCI, vol. 30, 2010, pages 4806 - 4814
UEDA, PHARMACOL THER, vol. 109, 2006, pages 57 - 77
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
Setsuko Mayama (JP)
Setsuko Mayama (JP)
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