Title:
USE OF A CX3C AGONIST FOR THE TREATMENT OF PAIN AND FOR PROMOTING NERVE REGENERATION
Document Type and Number:
WIPO Patent Application WO2004110416
Kind Code:
A3
Abstract:
The invention provides the use of an agonist of a CX3C receptor in the preparation of a medicament for the prevention or treatment of pain and to improve nerve regeneration after nerve in ury or damage. The pain may, for example, be neuropathic pain, inflammatory j pain or pain associated with cancer (other than neuropathic pain), surgery, visceral damage, headache or trauma. The agonist may be fractalkine or a derivative thereof.
Inventors:
WYNICK DAVID (GB)
Application Number:
PCT/GB2004/002391
Publication Date:
May 26, 2005
Filing Date:
June 04, 2004
Export Citation:
Assignee:
NEUROTARGETS LTD (GB)
WYNICK DAVID (GB)
WYNICK DAVID (GB)
International Classes:
A61K31/00; A61K38/19; G01N33/68; (IPC1-7): A61K38/19; A61P25/02; G01N33/68
Domestic Patent References:
| WO2002076990A1 | 2002-10-03 |
Other References:
WATKINS L R ET AL: "Glial activation: a driving force for pathological pain", TRENDS IN NEUROSCIENCE, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 8, 1 August 2001 (2001-08-01), pages 450 - 455, XP004273765, ISSN: 0166-2236
VERGE GAIL M ET AL: "Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions.", THE EUROPEAN JOURNAL OF NEUROSCIENCE. SEP 2004, vol. 20, no. 5, September 2004 (2004-09-01), pages 1150 - 1160, XP002321417, ISSN: 0953-816X
MILLIGAN E D ET AL: "Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.", THE EUROPEAN JOURNAL OF NEUROSCIENCE. NOV 2004, vol. 20, no. 9, November 2004 (2004-11-01), pages 2294 - 2302, XP002321418, ISSN: 0953-816X
WIESELER-FRANK JULIE ET AL: "Glial activation and pathological pain.", NEUROCHEMISTRY INTERNATIONAL. 2004 JUL-AUG, vol. 45, no. 2-3, July 2004 (2004-07-01), pages 389 - 395, XP002321419, ISSN: 0197-0186
COMBADIERE C ET AL: "Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 37, 11 September 1998 (1998-09-11), pages 23799 - 23804, XP002158116, ISSN: 0021-9258
VERGE GAIL M ET AL: "Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions.", THE EUROPEAN JOURNAL OF NEUROSCIENCE. SEP 2004, vol. 20, no. 5, September 2004 (2004-09-01), pages 1150 - 1160, XP002321417, ISSN: 0953-816X
MILLIGAN E D ET AL: "Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.", THE EUROPEAN JOURNAL OF NEUROSCIENCE. NOV 2004, vol. 20, no. 9, November 2004 (2004-11-01), pages 2294 - 2302, XP002321418, ISSN: 0953-816X
WIESELER-FRANK JULIE ET AL: "Glial activation and pathological pain.", NEUROCHEMISTRY INTERNATIONAL. 2004 JUL-AUG, vol. 45, no. 2-3, July 2004 (2004-07-01), pages 389 - 395, XP002321419, ISSN: 0197-0186
COMBADIERE C ET AL: "Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 37, 11 September 1998 (1998-09-11), pages 23799 - 23804, XP002158116, ISSN: 0021-9258
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