Title:
USE OF HETEROCYCLIC COMPOUND IN TREATING DISEASES RELATED TO KINASE DRUG-RESISTANT MUTATION AND METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/199503
Kind Code:
A1
Abstract:
The present invention relates to a use of a heterocyclic compound represented by formula I in the preparation of a drug for treating or assisting the treatment of diseases or conditions in an individual relating to a rearranged during transfection (RET) drug-resistant mutation and a treatment method using said heterocyclic compound.
Inventors:
CHEN ZHONGHUI (CN)
YUAN XIAOXI (CN)
LEI DONGMEI (CN)
HAN RUNFENG (CN)
HAN XIAOJUN (CN)
TIAN QIANG (CN)
SONG HONGMEI (CN)
WANG JINGYI (CN)
YUAN XIAOXI (CN)
LEI DONGMEI (CN)
HAN RUNFENG (CN)
HAN XIAOJUN (CN)
TIAN QIANG (CN)
SONG HONGMEI (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2022/081890
Publication Date:
September 29, 2022
Filing Date:
March 21, 2022
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/506; A61P35/00; C07D487/08
Domestic Patent References:
| WO2020168939A1 | 2020-08-27 | |||
| WO2021023209A1 | 2021-02-11 | |||
| WO2020235945A1 | 2020-11-26 | |||
| WO2012154518A1 | 2012-11-15 | |||
| WO2020168939A1 | 2020-08-27 |
Foreign References:
| US20180022732A1 | 2018-01-25 |
Other References:
NATURE REVIEWS CANCER, vol. 14, no. 3, 2014, pages 173 - 186
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STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
T. HIGUCHIV. STELLA: "Pro-drugs as Novel Delivery Systems", ACS SYMPOSIUM SERIES, vol. 14, pages 390 - 392
H. BUNDGAARD: "Design of Prodrugs", 1985, ELSEVIER
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
JOURNAL OF THORACIC ONCOLOGY, vol. 15, no. 4, 2020, pages 541 - 549
ANNALS OF ONCOLOGY: OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY, vol. 32, no. 2, 2021, pages 261 - 268
ANNALS OF ONCOLOGY: OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY, vol. 31, no. 12, 2020, pages 1599 - 1600
ANNALS OF ONCOLOGY: OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY, vol. 31, no. 12, 2020, pages 1725 - 1733
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
T. HIGUCHIV. STELLA: "Pro-drugs as Novel Delivery Systems", ACS SYMPOSIUM SERIES, vol. 14, pages 390 - 392
H. BUNDGAARD: "Design of Prodrugs", 1985, ELSEVIER
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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