Title:
USE OF HUMAN MESENCHYMAL STEM CELL SHEET IN TREATMENT OF UTERINE SCARS
Document Type and Number:
WIPO Patent Application WO/2024/022079
Kind Code:
A1
Abstract:
A use of a human mesenchymal stem cell sheet in the preparation of a drug for treating uterine scars, and a use of a human mesenchymal stem cell sheet in the preparation of a composition for treating a uterine scar in a subject. The human mesenchymal stem cell sheet is locally applied to the uterus of the subject. The human mesenchymal stem cell sheet can realize site-directed transplantation of mesenchymal stem cells, and no loss would occur because the cells are constrained by extracellular matrixes, such that the cells can directionally release cytokines at a scar site to exert functions.
More Like This:
Inventors:
CHANG DEHUA (CN)
GAO SHUANG (CN)
ZHAO YUFEI (CN)
LIU SHUAI (CN)
GAO SHUANG (CN)
ZHAO YUFEI (CN)
LIU SHUAI (CN)
Application Number:
PCT/CN2023/106157
Publication Date:
February 01, 2024
Filing Date:
July 06, 2023
Export Citation:
Assignee:
BOE TECHNOLOGY GROUP CO LTD (CN)
BOE REGENERATIVE MEDICINE TECH CO LTD (CN)
BOE REGENERATIVE MEDICINE TECH CO LTD (CN)
International Classes:
A61L27/38; A61K35/28; A61L27/50; A61P15/00
Domestic Patent References:
| WO2021148000A1 | 2021-07-29 |
Foreign References:
| CN114984052A | 2022-09-02 | |||
| CN111621474A | 2020-09-04 | |||
| CN105169485A | 2015-12-23 | |||
| CN105983133A | 2016-10-05 |
Other References:
杨芳 (YANG, FANG): "人脂肪干细胞膜片的构建及其对子宫内膜修复功能的初步研究 (The Experimental Study of Construction and Reparation Function of Adipose Derived Stem Cells Sheet)", 中国优秀硕士学位论文 医药卫生科技辑 (MEDICINE AND HEALTH SCIENCES, CHINESE MASTER’S THESES), no. 5, 15 May 2019 (2019-05-15)
KURAMOTO GORO, TAKAGI SOICHI, ISHITANI KEN, SHIMIZU TATSUYA, OKANO TERUO, MATSUI HIDEO: "Preventive Effect of Oral Mucosal Epithelial Cell Sheets on Intrauterine Adhesions", HUMAN REPRODUCTION, OXFORD JOURNALS, GB, vol. 30, no. 2, 4 December 2014 (2014-12-04), GB , pages 406 - 416, XP009552241, ISSN: 0268-1161, DOI: 10.1093/humrep/deu326
SHU-KUI ZHOU, ZHANG KAI-LE, YING WANG, QIANG FU: "Application of cell sheet technology in tissue engineering", CHINESE JOURNAL OF TISSUE ENGINEERING RESEARCH, vol. 20, no. 11, 11 March 2016 (2016-03-11), pages 1630 - 1636, XP093133580, ISSN: 2095-4344, DOI: 10.3969/j.issn.2095-4344.2016.11.017
KURAMOTO GORO, TAKAGI SOICHI, ISHITANI KEN, SHIMIZU TATSUYA, OKANO TERUO, MATSUI HIDEO: "Preventive Effect of Oral Mucosal Epithelial Cell Sheets on Intrauterine Adhesions", HUMAN REPRODUCTION, OXFORD JOURNALS, GB, vol. 30, no. 2, 4 December 2014 (2014-12-04), GB , pages 406 - 416, XP009552241, ISSN: 0268-1161, DOI: 10.1093/humrep/deu326
SHU-KUI ZHOU, ZHANG KAI-LE, YING WANG, QIANG FU: "Application of cell sheet technology in tissue engineering", CHINESE JOURNAL OF TISSUE ENGINEERING RESEARCH, vol. 20, no. 11, 11 March 2016 (2016-03-11), pages 1630 - 1636, XP093133580, ISSN: 2095-4344, DOI: 10.3969/j.issn.2095-4344.2016.11.017
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
Download PDF: