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Title:
USE OF PEMETREXED NEAR-INFRARED FLUORESCENT MOLECULE TARGETING α-TYPE FOLATE RECEPTOR AS FLUORESCENT TRACER
Document Type and Number:
WIPO Patent Application WO/2024/078004
Kind Code:
A1
Abstract:
Disclosed is a use of a pemetrexed near-infrared fluorescent molecule targeting an α-type folate receptor as a fluorescent tracer, the structural formula of the pemetrexed near-infrared fluorescent molecule being: formula (I). The foregoing active-targeting near-infrared fluorescent molecule has low affinity for a β-type folate receptor while retaining high affinity for the α-type folate receptor, can effectively distinguish tumors from inflammation, has advantages such as good water solubility and high fluorescence quantum yield, and has enormous development potential in the fields of near-infrared fluorescence images for tumor surgical navigation imaging and medical cell labeling.

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Inventors:
CAI HUIMING (CN)
WANG YIQING (CN)
LI YUNLONG (CN)
Application Number:
PCT/CN2023/101595
Publication Date:
April 18, 2024
Filing Date:
June 21, 2023
Export Citation:
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Assignee:
NANJING NUOYUAN MEDICAL DEVICES CO LTD (CN)
International Classes:
C07D487/04; C09K11/06; G01N21/64
Foreign References:
CN112010862A2020-12-01
CN115626928A2023-01-20
CN115504984A2022-12-23
CN114751907A2022-07-15
CN113185498A2021-07-30
CN104804463A2015-07-29
Attorney, Agent or Firm:
NANJING XINZHONGHE PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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