Title:
USE OF PPAR AGONISTS TO TREAT RUMINANTS
Document Type and Number:
WIPO Patent Application WO2005115369
Kind Code:
A3
Abstract:
The use of a PPAR agonist in the manufacture of a medicament to increase ruminant serum glucose concentrations, and preferably, the use for the palliative, prophylactic or curative treatment of ruminant disease associated with reduced serum glucose concentration. The ruminant disease associated with reduced serum glucose concentration includes fatty liver syndrome, dystocia, immune dysfunction, impaired immune function, toxif ication, primary ketosis, secondary ketosis, downer cow syndrome, indigestion, inappetence, retained placenta, displaced abomasum, mastitis, (endo-) -metritis, infertility, low fertility, lameness, subacute rumen acidosis and inadequate nutrient intake associated with stress e.g. heat, poor housing, overcrowding, shipping, dominance or illness, and to increase milk quality and yield.
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Inventors:
GOETZE LEOPOLD FRANZ (GB)
KEHRLI MARCUS EUGENE JR (US)
RICKETTS ANTHONY PAUL (US)
TAUBE PATRICK CARL (US)
KEHRLI MARCUS EUGENE JR (US)
RICKETTS ANTHONY PAUL (US)
TAUBE PATRICK CARL (US)
Application Number:
PCT/IB2005/001501
Publication Date:
November 16, 2006
Filing Date:
May 13, 2005
Export Citation:
Assignee:
PFIZER PROD INC (US)
GOETZE LEOPOLD FRANZ (GB)
KEHRLI MARCUS EUGENE JR (US)
RICKETTS ANTHONY PAUL (US)
TAUBE PATRICK CARL (US)
GOETZE LEOPOLD FRANZ (GB)
KEHRLI MARCUS EUGENE JR (US)
RICKETTS ANTHONY PAUL (US)
TAUBE PATRICK CARL (US)
International Classes:
A23K1/16; A61K31/192; A23K1/18; A61K31/451; A61P1/00; A61P1/16; A61P3/00; A61P15/00; A61P37/00
Domestic Patent References:
| WO2003084916A2 | 2003-10-16 | |||
| WO2004112776A2 | 2004-12-29 | |||
| WO2005115389A2 | 2005-12-08 | |||
| WO2005092845A1 | 2005-10-06 |
Foreign References:
| EP0998853A1 | 2000-05-10 |
Other References:
LOHRKE, B. ET AL: "The transcription factor peroxisome proliferator activated receptor .gamma. ( PPAR .gamma.) as a potential mediator of associations between metabolic and reproductive disorders", ARCHIV FUER TIERZUCHT , 42(SONDERHEFT), 138-140 CODEN: ARTZAJ; ISSN: 0003-9438, 1999, XP008065079
CAPPON G D ET AL: "Effects of the rat hepatic peroxisome proliferator, Wyeth 14,643, on the lactating goat", DRUG AND CHEMICAL TOXICOLOGY 2002 UNITED STATES, vol. 25, no. 3, 2002, pages 255 - 266, XP008055453, ISSN: 0148-0545
FROMENT PASCAL ET AL: "Expression and functional role of peroxisome proliferator-activated receptor-gamma in ovarian folliculogenesis in the sheep.", BIOLOGY OF REPRODUCTION. NOV 2003, vol. 69, no. 5, November 2003 (2003-11-01), pages 1665 - 1674, XP008068698, ISSN: 0006-3363
KELLER H ET AL: "FATTY ACIDS AND RETINOIDS REGULATE LIPID METABOLISM THROUGH ACTIVATION OF PPAR/RXR HETERODIMERS", EXPERIENTIA, BIRKHAUSER VERLAG. BASEL, CH, vol. 49, 1993, pages A11,ABSTRNO65, XP008035650, ISSN: 0014-4754
MATTOS R ET AL: "EFFECTS OF DIETARY FATTY ACIDS ON REPRODUCTION IN RUMINANTS", REVIEWS OF REPRODUCTION, JOURNAL OF REPRODUCTION AND FERTILITY, CAMBRIDGE, GB, vol. 5, no. 1, 2000, pages 38 - 45, XP008055454, ISSN: 1359-6004
CAPPON G D ET AL: "Effects of the rat hepatic peroxisome proliferator, Wyeth 14,643, on the lactating goat", DRUG AND CHEMICAL TOXICOLOGY 2002 UNITED STATES, vol. 25, no. 3, 2002, pages 255 - 266, XP008055453, ISSN: 0148-0545
FROMENT PASCAL ET AL: "Expression and functional role of peroxisome proliferator-activated receptor-gamma in ovarian folliculogenesis in the sheep.", BIOLOGY OF REPRODUCTION. NOV 2003, vol. 69, no. 5, November 2003 (2003-11-01), pages 1665 - 1674, XP008068698, ISSN: 0006-3363
KELLER H ET AL: "FATTY ACIDS AND RETINOIDS REGULATE LIPID METABOLISM THROUGH ACTIVATION OF PPAR/RXR HETERODIMERS", EXPERIENTIA, BIRKHAUSER VERLAG. BASEL, CH, vol. 49, 1993, pages A11,ABSTRNO65, XP008035650, ISSN: 0014-4754
MATTOS R ET AL: "EFFECTS OF DIETARY FATTY ACIDS ON REPRODUCTION IN RUMINANTS", REVIEWS OF REPRODUCTION, JOURNAL OF REPRODUCTION AND FERTILITY, CAMBRIDGE, GB, vol. 5, no. 1, 2000, pages 38 - 45, XP008055454, ISSN: 1359-6004
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