Title:
USE OF HIF1α PROTEIN AS BIOMARKER IN SCREENING OF SAFE LIVER FAT-LOWERING FEED ADDITIVE
Document Type and Number:
WIPO Patent Application WO/2020/228086
Kind Code:
A1
Abstract:
Disclosed is the use of an HIF1α protein as a biomarker in the screening of a safe liver fat-lowering feed additive. Aquatic animals can be fed with the feed additive, and the expression quantity of the HIF1α protein in the intestines before and after feeding is then detected, and if the expression quantity of the HIF1α protein in the intestines after feeding is not lower than that before feeding, the feed additive does not cause liver inflammation, liver damage, or alteration of the intestinal flora.
Inventors:
ZHOU ZHIGANG (CN)
ZHANG ZHEN (CN)
RAN CHAO (CN)
YANG YALIN (CN)
DING QIANWEN (CN)
LIU HONGLIANG (CN)
XIE MINGXU (CN)
GAO CHENCHEN (CN)
ZHANG ZHEN (CN)
RAN CHAO (CN)
YANG YALIN (CN)
DING QIANWEN (CN)
LIU HONGLIANG (CN)
XIE MINGXU (CN)
GAO CHENCHEN (CN)
Application Number:
PCT/CN2019/090847
Publication Date:
November 19, 2020
Filing Date:
June 12, 2019
Export Citation:
Assignee:
FEED RES INSTITUTE CHINESE ACADEMY OF AGRICULTURALSCIENCES (CN)
International Classes:
C12N1/20; A23K10/18; A23K20/10; A23K20/163; A23K50/80; A61K45/00; A61P1/00; A61P1/16; A61P31/00; C12Q1/04; C12Q1/68
Foreign References:
| CN1726277A | 2006-01-25 |
Other References:
WANG, YUHUA ET AL.: "Mechanism of Lactobacillus Rhamnosus Ameliorates Chronic Alcohol-Induced Liver Injury in Mice", JOURNAL OF CHINESE INSTITUTE OF FOOD SCIENCE AND TECHNOLOGY, PP. 22-27, vol. 18, no. 5, 31 May 2018 (2018-05-31), DOI: 20200316213541Y
JIA, DONG ET AL.: "Studies on Expression of Liver Hypoxia-inducible Factor-1α in Septic Rats and Its Relationship with Liver Damage", PROCEEDINGS OF THE 16TH ANNUAL CONGRESS OF THE CHINESE SOCIETY FOR EMERGENCY MEDICINE, P. 344, 4 July 2013 (2013-07-04), DOI: 20200316213254Y
MENG, XIAOLIN ET AL.: "Effect of Different Factors on the Fish Intestinal Microbiota", JOURNAL OF FISHERIES OF CHINA, PP. 143-150, vol. 43, no. 1, 15 January 2019 (2019-01-15), DOI: 20200316213534Y
JIA, DONG ET AL.: "Studies on Expression of Liver Hypoxia-inducible Factor-1α in Septic Rats and Its Relationship with Liver Damage", PROCEEDINGS OF THE 16TH ANNUAL CONGRESS OF THE CHINESE SOCIETY FOR EMERGENCY MEDICINE, P. 344, 4 July 2013 (2013-07-04), DOI: 20200316213254Y
MENG, XIAOLIN ET AL.: "Effect of Different Factors on the Fish Intestinal Microbiota", JOURNAL OF FISHERIES OF CHINA, PP. 143-150, vol. 43, no. 1, 15 January 2019 (2019-01-15), DOI: 20200316213534Y
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
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